This paper describes research on natural azo compounds isolated from fungi,plant,bacteria,and invertebrates.More than 120 biologically active diazene containing alkaloids demonstrate confirmed pharmacological activity...This paper describes research on natural azo compounds isolated from fungi,plant,bacteria,and invertebrates.More than 120 biologically active diazene containing alkaloids demonstrate confirmed pharmacological activity,including antitumor,antimicrobial,and antibacterial effects.The structures,origin,and biological activities of azo compounds are reviewed.Utilizing the computer program PASS,some structure–activity relationship new activities are also predicted,pointing toward possible new applications of these compounds.This article emphasizes the role of natural azo compounds as an important source of drug prototypes and leads for drug discovery.展开更多
Upon emergence of modern anticancer therapy,medical community is divided into two opposite camps,one of them claiming absolute necessity of using isolated or synthesized chemical compounds for efficient patient treatm...Upon emergence of modern anticancer therapy,medical community is divided into two opposite camps,one of them claiming absolute necessity of using isolated or synthesized chemical compounds for efficient patient treatment and another one advocating alternative cancer therapies,in particular those based on natural sources,including extracts from plants.It seems,in reality,that the two camps are reconcilable:while natural sources,plant extracts or juices play both curative and protective role,drugs represent the ultimate possibility to inhibit or reverse tumor development.In this paper we tried to analyze anti-breast cancer potencies of quite a few extracts from different plant sources and to compare their anti-proliferative efficiency of crude extracts with actions of their purified ingredients.展开更多
基金The work was partially supported(TAG and VVP)in the framework of the Russian State Academies of Sciences Fundamental Research Program for 2013-2020.
文摘This paper describes research on natural azo compounds isolated from fungi,plant,bacteria,and invertebrates.More than 120 biologically active diazene containing alkaloids demonstrate confirmed pharmacological activity,including antitumor,antimicrobial,and antibacterial effects.The structures,origin,and biological activities of azo compounds are reviewed.Utilizing the computer program PASS,some structure–activity relationship new activities are also predicted,pointing toward possible new applications of these compounds.This article emphasizes the role of natural azo compounds as an important source of drug prototypes and leads for drug discovery.
文摘Upon emergence of modern anticancer therapy,medical community is divided into two opposite camps,one of them claiming absolute necessity of using isolated or synthesized chemical compounds for efficient patient treatment and another one advocating alternative cancer therapies,in particular those based on natural sources,including extracts from plants.It seems,in reality,that the two camps are reconcilable:while natural sources,plant extracts or juices play both curative and protective role,drugs represent the ultimate possibility to inhibit or reverse tumor development.In this paper we tried to analyze anti-breast cancer potencies of quite a few extracts from different plant sources and to compare their anti-proliferative efficiency of crude extracts with actions of their purified ingredients.
