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全脑血流量增高与脑白质损害减轻有关 被引量:1
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作者 Bisschops R.H.C. van der graaf y. +2 位作者 Mali W.P.Th.M. van der Grond J. 李锐 《世界核心医学期刊文摘(神经病学分册)》 2005年第6期29-29,共1页
Background Low cerebral blood flow (CBF) has been associated with the presence of white matter lesions (WMLs). However, the power of these studies was insufficient (n = 20- 35) to determine whether flow is associated ... Background Low cerebral blood flow (CBF) has been associated with the presence of white matter lesions (WMLs). However, the power of these studies was insufficient (n = 20- 35) to determine whether flow is associated with WMLs. Purpose The aim of this study was to investigate whether total cerebral blood flow (tCBF) is associated with the severity of white matter lesions (WMLs) in a large patient sample. Subjects and methods 228 patients with clinical symptoms of cardiovascular disease had MRI of the brain, consisting of a T2- w FLAIR and a 2D phasecontrast flow measurement of the internal carotid arteries and the basilar artery. WMLs were graded according to prevalence and size of deep and periventricular WMLs. To determine the relation between tCBF and WMLs we used linear and logistic regression analysis adjusted for age, gender, intima media thickness and hypertension. Results We observed an inverse association between the tCBF and the total number of WMLs adjusted for age, gender, intima media thickness and hypertension [B = - 1,0 WML 95 % CI (- 2.0 to 0.0, p = 0.045) per 100 mL increase in tCBF]. The adjusted odds ratio for the presence of severe WMLs in patients with high tCBF ( > 675 mL/min) was 0.5 (95% CI 0.2- 1.0) compared with patients with normal tCBF. Conclusion In this study we found that high tCBF is associated with a decrease in presence and severity of WMLs. 展开更多
关键词 全脑血流量 脑白质 基底动脉 颈内动脉 心血管疾病 膜厚度 样本量 线性回归 临床症状 测量方法
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已确诊心血管疾病患者的颈动脉硬度与新发血管事件风险:SMART研究 被引量:1
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作者 Dijk J. M. Algra A. +2 位作者 van der graaf y. M. L. Bots 刘少伟 《世界核心医学期刊文摘(心脏病学分册)》 2005年第12期45-46,共2页
Aims: To study whether arterial stiffness is related to risk of new vascular events in patients with manifest arterial disease and to examine whether this relation varies between patients who differ with respect to ba... Aims: To study whether arterial stiffness is related to risk of new vascular events in patients with manifest arterial disease and to examine whether this relation varies between patients who differ with respect to baseline vascular risk, arterial stiffness, or systolic blood pressure(SBP). Methods and results: The study was performed in the first consecutive 2183 patients with manifest arterial disease enrolled in the SMART study(Second Manifestations of ARTerial disease), a cohort study among patients with manifest arterial disease or cardiovascular risk factors. Common carotid distension(i.e. the change in carotid diameter in systole relative to diastole) was measured at baseline by ultrasonography. With the distension, several stiffness parameters were determined. In the entire cohort, none of the carotid artery stiffness parameters was related to the occurrence of vascular events. However, decreased stiffness was related to decreased vascular risk in subjects with low baseline SBP. The relation of carotid stiffness with vascular events did not differ between tertiles of baseline risk and carotid stiffness. Conclusion: Carotid artery stiffness is no independent risk factor for vascular events in patients with manifest arterial disease. However, in patients with low SBP, decreased carotid stiffness may indicate a decreased risk of vascular events. 展开更多
关键词 动脉硬度 血管疾病患者 SMART 事件风险 动脉疾病 舒张期 队列研究 颈总动脉 超声检测 颈动脉内径
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明显动脉粥样硬化患者中颈动脉内膜中层厚度与新发血管事件风险的关系:SMART研究结果
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作者 Dijk J.M. van der graaf y. +2 位作者 Bots M.L. A. Algra 吴晓燕 《世界核心医学期刊文摘(心脏病学分册)》 2007年第1期54-55,共2页
目的:在普通人群中,颈动脉内膜中层厚度(CIMT)是发生血管事件的独立预测因素。目前,对CIMT和明显动脉疾病患者新发血管事件的相关性知之甚少。本文旨在评估此相关性的强度。方法与结果:本研究纳入入选SMART(动脉疾病继发表现)队列研究的... 目的:在普通人群中,颈动脉内膜中层厚度(CIMT)是发生血管事件的独立预测因素。目前,对CIMT和明显动脉疾病患者新发血管事件的相关性知之甚少。本文旨在评估此相关性的强度。方法与结果:本研究纳入入选SMART(动脉疾病继发表现)队列研究的前2374例有明显动脉疾病的连续患者,SMART队列研究的对象是有明显动脉疾病或心血管疾病危险因素的患者。测量基线时双侧颈总动脉CIMT。 展开更多
关键词 内膜中层厚度 SMART 动脉疾病 疾病危险因素 事件风险 双侧颈总动脉 队列研究 CIMT 非致死
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