Biliopancreatic diversion (BPD) for morbid obesity carries aserious risk of nutritional deficiencies that might impair embryogenesis.Consequently, attention should be given to the potential of risk to the fetus of BPD...Biliopancreatic diversion (BPD) for morbid obesity carries aserious risk of nutritional deficiencies that might impair embryogenesis.Consequently, attention should be given to the potential of risk to the fetus of BPD in women of childbearing age. We present the case of a pregnant woman who had undergone BPD 8 years previously, with documented vitamin A deficiency, who gave birth to a child with bilateral microphthalmia.Infectious and genetic causes of microphthalmia were excluded. A search of the literature revealed that vitamin A deficiency may cause a disruption of ocular development. We conclude that nutritional deficiencies may cause a spectrum of fetal malformations. As the effect of BPD relies on malabsorption,fetal risk should be considered before BPD is offered to morbid obese women of childbearing age.展开更多
We report the presence of iopromide in the bowel and urine of a preterm infant, born 10 days after intravenous administration of the nonionic monomer to his mother. Excessive urinary iodine excretion and borderline hy...We report the presence of iopromide in the bowel and urine of a preterm infant, born 10 days after intravenous administration of the nonionic monomer to his mother. Excessive urinary iodine excretion and borderline hyperthyrotropinaemia were observed in the infant. Moreover, crossing of the fetal bloodbrain barrier was demonstrated by detection of the angiographic material in CSF and thus direct fetal neurotoxic effects cannot be excluded. Conclusion:These widely used contrast media may cross the placenta and accumulate in various fetal tissues in significant amounts causing possible neonatal toxicity. Therefore the perinatal safety of these diagnostic agents should at least be questioned.展开更多
Biliopancreatic diversion(BPD)for morbid obesity carries a serious risk of nutritional deficiencies that might impair embryogenesis.Consequently,attention should be given to the potential of risk to the fetus of BPD i...Biliopancreatic diversion(BPD)for morbid obesity carries a serious risk of nutritional deficiencies that might impair embryogenesis.Consequently,attention should be given to the potential of risk to the fetus of BPD in women of childbearing age.We present the case of a pregnant woman who had undergone BPD 8 years previously,with documented vitamin A deficiency,who gave birth to a child with bilateral microphthalmia.Infectious and genetic causes of microphthalmia were excluded.A search of the literature revealed that vitamin A deficiency may cause a disruption of ocular development.We conclude that nutritional deficiencies may cause a spectrum of fetal malformations.As the effect of BPD relies on malabsorption,fetal risk should be considered before BPD is offered to morbid obese women of childbearing age.展开更多
文摘Biliopancreatic diversion (BPD) for morbid obesity carries aserious risk of nutritional deficiencies that might impair embryogenesis.Consequently, attention should be given to the potential of risk to the fetus of BPD in women of childbearing age. We present the case of a pregnant woman who had undergone BPD 8 years previously, with documented vitamin A deficiency, who gave birth to a child with bilateral microphthalmia.Infectious and genetic causes of microphthalmia were excluded. A search of the literature revealed that vitamin A deficiency may cause a disruption of ocular development. We conclude that nutritional deficiencies may cause a spectrum of fetal malformations. As the effect of BPD relies on malabsorption,fetal risk should be considered before BPD is offered to morbid obese women of childbearing age.
文摘We report the presence of iopromide in the bowel and urine of a preterm infant, born 10 days after intravenous administration of the nonionic monomer to his mother. Excessive urinary iodine excretion and borderline hyperthyrotropinaemia were observed in the infant. Moreover, crossing of the fetal bloodbrain barrier was demonstrated by detection of the angiographic material in CSF and thus direct fetal neurotoxic effects cannot be excluded. Conclusion:These widely used contrast media may cross the placenta and accumulate in various fetal tissues in significant amounts causing possible neonatal toxicity. Therefore the perinatal safety of these diagnostic agents should at least be questioned.
文摘Biliopancreatic diversion(BPD)for morbid obesity carries a serious risk of nutritional deficiencies that might impair embryogenesis.Consequently,attention should be given to the potential of risk to the fetus of BPD in women of childbearing age.We present the case of a pregnant woman who had undergone BPD 8 years previously,with documented vitamin A deficiency,who gave birth to a child with bilateral microphthalmia.Infectious and genetic causes of microphthalmia were excluded.A search of the literature revealed that vitamin A deficiency may cause a disruption of ocular development.We conclude that nutritional deficiencies may cause a spectrum of fetal malformations.As the effect of BPD relies on malabsorption,fetal risk should be considered before BPD is offered to morbid obese women of childbearing age.
