Anetoderma is a rare cutaneous disease characterized by a loss of normal elast ic tissue that is presented clinically as localized areas of wrinkled or flaccid skin. This form may be associated with several immunologi...Anetoderma is a rare cutaneous disease characterized by a loss of normal elast ic tissue that is presented clinically as localized areas of wrinkled or flaccid skin. This form may be associated with several immunological abnormalities, mos t notably lupus erythematosus and antiphospholipid antibodies with or without cl inical manifestations of the antiphospholipid syndrome. A retrospective study wa s conducted with the aim of summarizing the clinical characteristics, course and laboratory findings in three women with anetoderma-associated lupus erythemato sus panniculitis, an unusual variant of cutaneous lupus erythematosus. The 3 pat ients (of the 12 patients with lupus erythematosus panniculitis seen by us since 1990) were all at a young age at onset of panniculitis (median, 22 years). None of the patients developed severe systemic involvement up to 9 years (median, 5 years) from onset of the disease. The most noteworthy laboratory finding was the presence of antiphospholipid antibodies. Anetodermic lupus erythematosus pannic ulitis may be regarded as an uncommon variant of cutaneous lupus erythematosus m ainly affecting young females and showing a favourable clinical course, although the patients should be followed and screened for the emergence of antiphospholi pid syndrome. Antiphospholipid antibodies could play a role in the elastolytic p rocess, leading to anetoderma.展开更多
文摘Anetoderma is a rare cutaneous disease characterized by a loss of normal elast ic tissue that is presented clinically as localized areas of wrinkled or flaccid skin. This form may be associated with several immunological abnormalities, mos t notably lupus erythematosus and antiphospholipid antibodies with or without cl inical manifestations of the antiphospholipid syndrome. A retrospective study wa s conducted with the aim of summarizing the clinical characteristics, course and laboratory findings in three women with anetoderma-associated lupus erythemato sus panniculitis, an unusual variant of cutaneous lupus erythematosus. The 3 pat ients (of the 12 patients with lupus erythematosus panniculitis seen by us since 1990) were all at a young age at onset of panniculitis (median, 22 years). None of the patients developed severe systemic involvement up to 9 years (median, 5 years) from onset of the disease. The most noteworthy laboratory finding was the presence of antiphospholipid antibodies. Anetodermic lupus erythematosus pannic ulitis may be regarded as an uncommon variant of cutaneous lupus erythematosus m ainly affecting young females and showing a favourable clinical course, although the patients should be followed and screened for the emergence of antiphospholi pid syndrome. Antiphospholipid antibodies could play a role in the elastolytic p rocess, leading to anetoderma.
