期刊文献+
共找到3篇文章
< 1 >
每页显示 20 50 100
Mutant p53-a potential player in shaping the tumor-stroma crosstalk 被引量:3
1
作者 Yan Stein Ronit Aloni-Grinstein varda rotter 《Journal of Molecular Cell Biology》 SCIE CAS CSCD 2019年第7期600-604,共5页
A plethora of studies suggest that the non-transformed cellularand non-ceHular comp on ents of the tumor,collectively known as the tumor microenvironment,have a significa nt impact on the tumorigenic process.It was su... A plethora of studies suggest that the non-transformed cellularand non-ceHular comp on ents of the tumor,collectively known as the tumor microenvironment,have a significa nt impact on the tumorigenic process.It was suggested that the microenvironment,which initially restricts tumor development,is recruited by the tumor and main tains a crosstalk that further promotes cancer progression. 展开更多
关键词 plethora TUMOR PROGRESSION
原文传递
p53 balances between tissue hierarchy and anarchy
2
作者 Gabriela Koifman Ronit Aloni-Grinstein varda rotter 《Journal of Molecular Cell Biology》 SCIE CAS CSCD 2019年第7期553-563,共11页
Normal tissues are organized in a hierarchical model,whereas at the apex of these hierarchies reside stem cells (SCs) capable of self-renewal and of producing differentiated cellular progenies,leading to normal develo... Normal tissues are organized in a hierarchical model,whereas at the apex of these hierarchies reside stem cells (SCs) capable of self-renewal and of producing differentiated cellular progenies,leading to normal development and homeostasis.Alike,tumors are organized in a hierarchical manner,with cancer SCs residing at the apex,contributing to the development and nourishment of tumors .p53,the well-known 'guardian ofthe genome',possesses various roles in embryonic development as well as in adult SC life and serves as the ‘guardian of tissue hierarchy’.Moreover,p53 serves as a barrier for dedifferentiation and reprogramming by constraining the cells to a somatic state and preventing their conversion to SCs.On the contrary,the mutant forms of p53 that lost theirtumor suppressor activity and gain oncogenic functions serve as 'inducers oftissue anarchy' and promote cancer development.In this review,we discuss these two sides ofthe p53 token that sentence a tissue either to an ordered hierarchy and life or to anarchy and death.A better understanding of these processes may open new horizons for the development of new cancer therapies. 展开更多
关键词 P53 STEM cell gain of function cancer STEM CELLS adult STEM CELLS embryonic development TISSUE HIERARCHY
原文传递
Corrigendum to‘p53 balances between tissue hierarchy and anarchy’
3
作者 Gabriela Koifman Ronit Aloni-Grinstein varda rotter 《Journal of Molecular Cell Biology》 SCIE CAS CSCD 2019年第12期1106-1106,共1页
In this article (p.559, third paragraph), the reference in ‘The identified ESC gene signature-derived genes correlated with poor patient survival and human tumors harboring p53 hotspot mutations (Lonetto et al., 2018... In this article (p.559, third paragraph), the reference in ‘The identified ESC gene signature-derived genes correlated with poor patient survival and human tumors harboring p53 hotspot mutations (Lonetto et al., 2018)’ was incorrectly cited. It should be changed to ‘(Koifman et al., 2018)’. The conclusions of the review are not affected and the authors apologize for this error. 展开更多
关键词 al. COR P53
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部