Compensatory/adaptive mechanisms in the brain are hy- pothesized to be involved in its protection from the Alz- heimer＇s disease （AD） progression. These mechanisms are activated by malfunctioning of various brain s...Compensatory/adaptive mechanisms in the brain are hy- pothesized to be involved in its protection from the Alz- heimer＇s disease （AD） progression. These mechanisms are activated by malfunctioning of various brain systems： anti- oxidant, neurotrophic, neurotransmitter, immune, and oth- ers. Detailed analysis of compensatory^adaptive capabilities of these systems might be a start point for further discovery and development of perspective approaches for early diag- nostics and treatment of AD and associated neurodegenera- tive disorders.展开更多
An imbalance between activities of different structures and neurotransmitter systems in the brain is suggested to be the main cause of its abnormal functioning in neurodegenerative pathologies.Electroencephalogram（EE...An imbalance between activities of different structures and neurotransmitter systems in the brain is suggested to be the main cause of its abnormal functioning in neurodegenerative pathologies.Electroencephalogram（EEG）registered from areas specifically linked with a disease in combination with pharmacological testing of involved mediatory systems allows discovery of its progression and mechanism（s）. This, in turn, potentiates development of perspective approaches for early diagnostic and effective treatment of neurodegenerative disorders.展开更多
基金supported by grant KOMFI 13-04-40106-H (Russia):"Structure-functional studies of р-75 receptor–molecular target for neurodegenerative diseases immunotherapy"Grant RFBR 13-04-00633A (Russia):"Study of role of receptor for advanced glycation end products (RAGE) in mechanisms of beta-amyloid neurotoxicity in model of sporadic Alzheimer’s disease"
文摘Compensatory/adaptive mechanisms in the brain are hy- pothesized to be involved in its protection from the Alz- heimer＇s disease （AD） progression. These mechanisms are activated by malfunctioning of various brain systems： anti- oxidant, neurotrophic, neurotransmitter, immune, and oth- ers. Detailed analysis of compensatory^adaptive capabilities of these systems might be a start point for further discovery and development of perspective approaches for early diag- nostics and treatment of AD and associated neurodegenera- tive disorders.
基金Grant RFBR 16-04-00942(Russia)to NB:“A study of the brain dopaminergic system involvement in mechanisms of Alzheimer’s disease on models of its sporadic and inherited types”
文摘An imbalance between activities of different structures and neurotransmitter systems in the brain is suggested to be the main cause of its abnormal functioning in neurodegenerative pathologies.Electroencephalogram（EEG）registered from areas specifically linked with a disease in combination with pharmacological testing of involved mediatory systems allows discovery of its progression and mechanism（s）. This, in turn, potentiates development of perspective approaches for early diagnostic and effective treatment of neurodegenerative disorders.
