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A ConA-like lectin isolated from <i>Canavalia maritima</i>seeds alters the expression of genes related to virulence and biofilm formation in <i>Streptococcus mutans</i>
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作者 Theodora Thays Arruda Cavalcante victor alves carneiro +8 位作者 Cinara carneiro Neves Humberlania de Sousa Duarte Maria Gleiciane de Queiroz Martins Francisco Vassiliepe Sousa Arruda Mayron alves de Vasconcelos Hélcio Silva dos Santos Rodrigo Maranguape da Silva Cunha Benildo Sousa Cavada Edson Holanda Teixeira 《Advances in Bioscience and Biotechnology》 2013年第12期1073-7078,共6006页
Bacteria form biofilms as an adaptive mechanism in response to environmental changes. Streptococcus mutans is the biofilm-forming bacterium that is primarily associated with dental caries. The expression of important ... Bacteria form biofilms as an adaptive mechanism in response to environmental changes. Streptococcus mutans is the biofilm-forming bacterium that is primarily associated with dental caries. The expression of important genes by bacteria in biofilms is different from that of planktonic cells. Lectins are proteins that bind specifically to carbohydrates and may have important biological activities on bacterial cells, acting as antibacterial and anti-biofilm agents. ConM (Canavalia maritima lectin) is a protein that is able to inhibit the planktonic growth and biofilm formation of S. mutans. In this context, this study aimed to evaluate the effects of ConM and concanavalin A (ConA) on the expression of genes related to virulence and biofilm formation in S. mutans. The results showed that ConM significantly reduced the expression of genes encoding enzymes related to adhesion, formation and regulation of biofilms. On the contrary, ConA did not alter the expression of the genes studied. Because the two lectins have a high degree of similarity, the differences in the actions of ConM and ConA may be explained by the small structural differences in the carbohydrate recognition domain of the lectins. 展开更多
关键词 STREPTOCOCCUS mutants LECTIN Canavalia maritima Biofilm EXPRESSION
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