Co-infection of hepatitis B and hepatitis C virus in human immunodeficiency virus-infected patients in New York City,United States

瞄准：为了学习流行和风险因素，与人的免疫不全与三倍的感染联系了在一张城市的诊所人口的病毒(HIV )/hepatitis B (HBV )/hepatitis C 病毒(HCV ) 。方法：5639 个病人的回顾的图表评论在纽约城市里在圣卢凯斯鲁塞韦尔特医院 HIV 诊所(全面照顾的中心) 列在后面，从 1999 年 1 月的美国到 2007 年 5 月。下列人口统计的特征被分析：年龄，性别，种族和 HIV 冒因素的风险。多重逻辑回归分析被执行在这些病毒的获得上评估人口统计的因素的影响。结果：HIV/HBV， HIV/HCV 和 HIV/HBV/HCV 感染在 252/5639 (4.47%) 被检测， 1411/5639 (25.02%) 和 89/5639 (1.58%) 病人分别地。HIV/HBV 合作感染与男性被联系(或 1.711；P = 0.005 ) ，黑色跑(或 2.091；P 【 0.001 ) ，人与 \O 性交人(MSM )( 或 1.747；P = 0.001 ) ，静脉内的药使用(IDU )( 或 0.114；P 【 0.001 ) ， IDU 和异性爱的活动(或 0.247；P = 0.018 ) ，或未知(或 1.984；P = 0.004 ) 。HIV/HCV 合作感染与男性被联系(或 1.241；P = 0.011 ) ，黑色跑(或 0.788；P = 0.036 ) ， MSM (或 0.565；P 【 0.001 ) ， IDU (或 8.956；P 【 0.001 ) ， IDU 和异性爱的活动(或 9.106；P 【 0.001 ) ， IDU 和 MSM (或 9.179；P 【 0.001 ) ，或输送(或 3.224；P 【 0.001 ) 。HIV/HBV/HCV 合作感染与男性被联系(或 2.156；P = 0.015 ) ， IDU (或 6.345；P 【 0.001 ) ， IDU 和异性爱的活动(或 9.731；P 【 0.001 ) ， IDU 和 MSM (或 9.228；P 【 0.001 ) ，或未知(或 4.219；P = 0.007 ) 。结论：我们的学习证明有 HBV/HCV/HIV 的合作感染显著地与 IDU 被联系。这些结果加亮需要加强教育和综合照顾的最佳的模型，特别地为有 IDU 的人口，到减少病毒的传播的风险。

Predictors of loss of hepatitis B surface antigen in HIV-infected patients

AIM:To study factors associated with loss of hepatitis B surface antigen (HBsAg) in patients co-infected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV).METHODS:We retrospectively reviewed the medical records of 5681 patients followed up at two New York City HIV clinics from January 1999 to May 2007.Clinical and laboratory parameters including baseline and follow-up HIV viral loads,CD4 cell counts,alanine transaminase levels,demographics,presence of hepatitis C infection,and treatment with highly active antiretroviral therapy dually active against both HIV and HBV infection,were analyzed to determine factors associated with loss of HBsAg.RESULTS:Three hundred and fifty five patients (355/5681,6.84%) were co-infected with HIV and HBV and were evaluated.Of these,226 patients with more than 12 mo follow-up were included in further analysis to determine factors associated with loss of HBsAg in the long-term follow-up.In the univariate analysis,baseline CD4 cell count was associated with loss of HBsAg (P=0.052).Cox regression analysis revealed that loss of HBsAg was associated with baseline CD4 cell count > 500 cells/mm3 (P=0.016,odds ratio:76.174,95% confidence interval:2.233-2598.481).CONCLUSION:Our study showed an interesting association of loss of HBsAg in HIV-HBV co-infected patients with higher CD4 cell count,suggesting that T-cell cytolytic activity against HBV may still be effective in clearing HBV infection.