Mutations in the receptor binding domain(RBD)of SARS-CoV-2 spike protein have given birth to the new variants of concern viz.Delta and Omicron strain.As we are using vaccines which are either mRNA of spike protein of ...Mutations in the receptor binding domain(RBD)of SARS-CoV-2 spike protein have given birth to the new variants of concern viz.Delta and Omicron strain.As we are using vaccines which are either mRNA of spike protein of Wuhan strain or its whole virion vaccine,these vaccines will trigger antibodies to be able to bind with the epitopes of spike protein of Wuhan strain.There appears a need to study whether vaccine generated circulating neutralizing antibodies in vaccinated people are able to neutralize the receptor binding domain of spike protein of currently circulating Delta and Omicron strains as well.We need to address this contention in two phases:first to undertake docking studies of vaccine generated antibodies with Wuhan,Delta and Omicron strains and second to conduct the wet lab studies and observe antigen-antibody bindings employing Immunofluorescence and Cryo-Electron Microscopic studies.The present paper reports results of docking studies using bioinformatic softwares to provide the baseline information for wet lab studies.展开更多
The present paper reports the unusual enhancement of endurance life of ball bearings subjected to carbonitriding treatment. The microstructure was characterized by scanning electron microscopy and correlated with hard...The present paper reports the unusual enhancement of endurance life of ball bearings subjected to carbonitriding treatment. The microstructure was characterized by scanning electron microscopy and correlated with hardness and X-ray diffraction analysis. Endurance tests at 90% reliability revealed that the carbonitrided bearings exhibit nearly ten times more life than the non-carbonitrided bearings. This is attributed to synergic combination of retained austenitic, fine martensitic microstructure and ultrafine carbide precipitates obtained by carbonitriding treatment.展开更多
基金funded by Indian Council of Medical Research,Grant Number 2021-6369.
文摘Mutations in the receptor binding domain(RBD)of SARS-CoV-2 spike protein have given birth to the new variants of concern viz.Delta and Omicron strain.As we are using vaccines which are either mRNA of spike protein of Wuhan strain or its whole virion vaccine,these vaccines will trigger antibodies to be able to bind with the epitopes of spike protein of Wuhan strain.There appears a need to study whether vaccine generated circulating neutralizing antibodies in vaccinated people are able to neutralize the receptor binding domain of spike protein of currently circulating Delta and Omicron strains as well.We need to address this contention in two phases:first to undertake docking studies of vaccine generated antibodies with Wuhan,Delta and Omicron strains and second to conduct the wet lab studies and observe antigen-antibody bindings employing Immunofluorescence and Cryo-Electron Microscopic studies.The present paper reports results of docking studies using bioinformatic softwares to provide the baseline information for wet lab studies.
文摘The present paper reports the unusual enhancement of endurance life of ball bearings subjected to carbonitriding treatment. The microstructure was characterized by scanning electron microscopy and correlated with hardness and X-ray diffraction analysis. Endurance tests at 90% reliability revealed that the carbonitrided bearings exhibit nearly ten times more life than the non-carbonitrided bearings. This is attributed to synergic combination of retained austenitic, fine martensitic microstructure and ultrafine carbide precipitates obtained by carbonitriding treatment.
