Aim:To investigate the distensibility of the common carotid artery(CCA),baroreflex sensitivity(BRS)and its relation to plasma homocysteine concentration in exfoliation syndrome or exfoliation glaucoma(XFS/XFG).Methods...Aim:To investigate the distensibility of the common carotid artery(CCA),baroreflex sensitivity(BRS)and its relation to plasma homocysteine concentration in exfoliation syndrome or exfoliation glaucoma(XFS/XFG).Methods:Homocysteine concentrations were measured in 30 XFS/XFG patients and 18 age matched controls.In 21 patients and 17 controls the end diastolic diameter of the CCA and pulsatile distension were measured and BRS was calculated.Results:There was no significant difference between the groups in sex distribution,age,heart rate,blood pressure,systemic diseases,or medication.In XFS/XFG patients homocysteine concentration was significantly elevated(unpaired t test,p=0.023),and CCA stiffness was higher(p< 0.05),while strain,cross sectional compliance coefficient,distensibility,and BRS were significantly reduced compared to the controls(Mann-Whitney U test,p≤ 0.013 for each parameter).In XFS/XFG patients a positive correlation was found between age and plasma homocysteine level(Pearson’s correlation,r=0.490,p=0.007),and a negative correlation between age and BRS(Kendall’s correlation r=-0.374,p=0.021),as well as between homocysteine concentration and BRS(Kendall’s correlation r=-0.377,p=0.024).No correlation was seen between these variables in the control group.Conclusions:These results suggest a pathological large artery function as well as altered parasympathetic vascular control in XFS/XFG which increases with age and with higher homocysteine concentration.展开更多
文摘Aim:To investigate the distensibility of the common carotid artery(CCA),baroreflex sensitivity(BRS)and its relation to plasma homocysteine concentration in exfoliation syndrome or exfoliation glaucoma(XFS/XFG).Methods:Homocysteine concentrations were measured in 30 XFS/XFG patients and 18 age matched controls.In 21 patients and 17 controls the end diastolic diameter of the CCA and pulsatile distension were measured and BRS was calculated.Results:There was no significant difference between the groups in sex distribution,age,heart rate,blood pressure,systemic diseases,or medication.In XFS/XFG patients homocysteine concentration was significantly elevated(unpaired t test,p=0.023),and CCA stiffness was higher(p< 0.05),while strain,cross sectional compliance coefficient,distensibility,and BRS were significantly reduced compared to the controls(Mann-Whitney U test,p≤ 0.013 for each parameter).In XFS/XFG patients a positive correlation was found between age and plasma homocysteine level(Pearson’s correlation,r=0.490,p=0.007),and a negative correlation between age and BRS(Kendall’s correlation r=-0.374,p=0.021),as well as between homocysteine concentration and BRS(Kendall’s correlation r=-0.377,p=0.024).No correlation was seen between these variables in the control group.Conclusions:These results suggest a pathological large artery function as well as altered parasympathetic vascular control in XFS/XFG which increases with age and with higher homocysteine concentration.
