Retinal ganglion cell(RGC)function in health and disease:RGCs are extremely high-maintenance neurons connecting the eye to the brain trough the optic nerve.In order to produce and propagate action potentials along the...Retinal ganglion cell(RGC)function in health and disease:RGCs are extremely high-maintenance neurons connecting the eye to the brain trough the optic nerve.In order to produce and propagate action potentials along the unmyelinated RGC axons and support axonal transport of materials back and forth from the eye to the brain,RGC require large amounts of energy.Therefore,RGCs are under considerable metabolic stress when healthy and become particularly vulnerable in disease,resulting in blindness(Morgan,2004).展开更多
基金supported by the NIH-NEI RO1 EY019077,NIH center grant P30 EY014801,unrestricted grant to Bascom Palmer Eye Institute from Research to Prevent Blindness,Inc。
文摘Retinal ganglion cell(RGC)function in health and disease:RGCs are extremely high-maintenance neurons connecting the eye to the brain trough the optic nerve.In order to produce and propagate action potentials along the unmyelinated RGC axons and support axonal transport of materials back and forth from the eye to the brain,RGC require large amounts of energy.Therefore,RGCs are under considerable metabolic stress when healthy and become particularly vulnerable in disease,resulting in blindness(Morgan,2004).
