Reviving Fertility:Phytochemicals as Natural Allies in the Fight against Non-genetic Male Infertility

Background:Male infertility poses a growing challenge to the healthcare system,with its prevalence on the rise.Unhealthy lifestyle,food,and addictions such as smoking,alcoholism,etc.accelerate the occurrence.While several approaches are being investigated to prevent and treat this condition,each therapeutic approach has its drawbacks.Traditional medications continue to play a crucial role in the healthcare system.In recent years,there has been a shift towards determining the efficacy of phytochemicals(or,herbal drugs)as remedies.Objective:To evaluate the effect of various herbs,plant,metabolites,or a part of plant in management of non-genetic male infertility.Methods:The male infertility-associated keywords were searched in PubMed,excluding those non-English writen papers.A total of 146 pertinent and closely connected records were included for full reading and inclusion in the systemic evaluation.Results:The manuscript focuses on individual herbal drug components,their active ingredients,their role in improving the condition and quality of life,and decreasing the prevalence of male infertility.Conclusion:Herbal medicinal plants show promising outcomes to treat male infertility.Herbal alternatives are appealing and have regained popularity.The future holds promise for some of these herbal treatments to advance with many showing improved outcomes in males with infertility issues.

Nature meets technology:Harnessing nanotechnology to unleash the power of phytochemicals

Background:Phytochemicals encompass a diverse array of bioactive substances originating from plants,exhibit-ing a broad spectrum of possible health-promoting effects.Nonetheless,the clinical uses of these compounds are restricted due to their limited solubility,stability,bioavailability,and target selectivity.Nanotechnology-based delivery methods present a viable approach to address these problems and enhance the properties and biological activity of phytochemicals.Nanoformulations have the potential to augment the solubility,bioavailability,and pharmacokinetics of phytochemicals by means of several methods.One potential approach to enhance the surface area and solubility of phytochemicals is by lowering their particle size.The process of adsorption of surfactants onto phytochemical particles can lead to the formation of micelles,which exhibit solubility in water.Nanofor-mulations have the potential to enhance the uptake of phytochemicals across many biological barriers,including the intestinal epithelium.Objective:To study the potential of nanoformulation in enhancing the therapeutic action of phytochemicals Method:Systemic review was performed while considering some aspects of PRISM guidelines.Result:The nanoparticles have a great potential in delivering the phytochemicals and could of great help in the management of various diseases.Although,exhaustive research and clinical trials are yet demanded to provide the evidential proof for the same.Conclusion:In conclusion,the utilisation of ligand-functionalized nanoparticles enables the precise targeting of phytochemicals to particular cells or tissues.The field of nanotechnology has significant promise in transform-ing the advancement and administration of phytochemicals for medicinal and preventative applications.The utilisation of nanotechnology holds promise in addressing the obstacles related to the physicochemical charac-teristics of phytochemicals,hence enabling the development of enhanced and precise delivery systems for these advantageous molecules.

Phytochemical Loaded Nanovehicles of Biopolymer for Breast Cancer:A Systemic Review

Background:Breast cancer is one of the most common malignancies affecting women worldwide,emphasizing the need for effective therapeutic strategies.Phytochemicals derived from plants have gained significant attention due to their potential anticancer properties.Objective:This review aims to comprehensively assess the existing literature on using phytochemical-loaded for-mulations as a therapeutic approach for breast cancer.By analyzing the available evidence,we aim to determine the potential benefits and limitations of these formulations in terms of their anticancer activity,bioavailability,and safety.Methods:A systematic search of relevant databases was conducted to identify studies investigating phytochemical-loaded formulations in the context of breast cancer treatment.The inclusion criteria encompassed clinical trials,preclinical studies,and in-vitro experiments that reported using phytochemicals in various formulations for breast cancer treatment.Data extraction was performed to ensure the reliability and validity of the included studies.Results:The review highlights the diverse range of phytochemicals used in different formulations for breast cancer treatment.Findings suggest that these formulations exhibit promising anticancer effects by targeting mul-tiple signaling pathways in breast cancer progression,including cell proliferation,apoptosis,angiogenesis,and metastasis.Moreover,various delivery systems,such as nanoparticles,liposomes,and micelles,have enhanced phytochemicals’bioavailability and targeted delivery.Conclusion:Phytochemical-loaded formulations hold immense potential as a therapeutic approach for breast cancer treatment.The reviewed evidence indicates their ability to inhibit tumor growth,enhance chemotherapy effectiveness,and reduce adverse effects.However,further research is warranted to optimize the formulation strategies,investigate the long-term safety profiles,and conduct large-scale clinical trials to establish their efficacy and applicability in clinical settings.These findings contribute to developing novel phytochemical-based therapies for breast cancer,offering new avenues for personalized and targeted treatment options.

COVAX-19 ■Vaccine:Completely blocks virus transmission to non-immune individuals

Various vaccine platforms are geared against COVID-19 vaccine development to produce immunogens in cells.To design a recombinant protein-based COVID-19 vaccine,Vaxine pty Ltd used computer models of the spike protein and its human receptor,ACE2,to identify how the virus infects human cells.Based on this,the COVAX-19 ■vaccine is synthesized.It does reduce not only COVID-19 disease but also blocks virus shedding and transmission.Researchers are optimistic that this vaccine candidate could be clinically available soon with sufficient vaccine efficacy with a considerable amount of reduction in vaccination-related side effects.

Ayurvedic and Other Herbal Remedies for Dengue: An Update

Dengue fever is a flu-like ailment propagated by female mosquitos of the Aedes aegypti species.It is also known as dandaka jwara in Ayurveda.It is most common in the world’s subtropical and tropical climate zones.Vomiting,severe headache,nausea,rashes,joint pain,pain behind the eyes,muscle pain,and swollen glands are all common dengue symptoms.If not handled promptly,these symptoms can lead to more severe issues such as exhaustion,blood in the vomit,continuous vomiting,bleeding gums,restlessness,severe abdominal pain,and rapid bleeding.Because there is no specific medication for dengue fever,the disease is treated by eliminating and managing the symptoms.Fortunately,there are a variety of ayurvedic remedies(like Carica papaya L.,Cissampelos pareira L.,etc.)that can help to tackle the same by strengthening the immune system and controlling hyperthermia.This review article provides a comprehensive overview of dengue virus infections,clinical symptoms,diagnosis,mitigation,and treatments,focusing on ayurvedic and herbal remedies.