Elevated cardiovascular risk and acute events in hospitalized colon cancer survivors:A decade-apart study of two nationwide cohorts

BACKGROUND Over the years,strides in colon cancer detection and treatment have boosted survival rates;yet,post-colon cancer survival entails cardiovascular disease(CVD)risks.Research on CVD risks and acute cardiovascular events in colorectal cancer survivors has been limited.AIM To compare the CVD risk and adverse cardiovascular outcomes in current colon cancer survivors compared to a decade ago.METHODS We analyzed 2007 and 2017 hospitalization data from the National Inpatient Sample,studying two colon cancer survivor groups for CVD risk factors,mortality rates,and major adverse events like pulmonary embolism,arrhythmia,cardiac arrest,and stroke,adjusting for confounders via multivariable regression analysis.RESULTS Of total colon cancer survivors hospitalized in 2007(n=177542)and 2017(n=178325),the 2017 cohort often consisted of younger(76 vs 77 years),male,African-American,and Hispanic patients admitted non-electively vs the 2007 cohort.Furthermore,the 2017 cohort had higher rates of smoking,alcohol abuse,drug abuse,coagulopathy,liver disease,weight loss,and renal failure.Patients in the 2017 cohort also had higher rates of cardiovascular comorbidities,including hypertension,hyperlipidemia,diabetes,obesity,peripheral vascular disease,congestive heart failure,and at least one traditional CVD(P<0.001)vs the 2007 cohort.On adjusted multivariable analysis,the 2017 cohort had a significantly higher risk of pulmonary embolism(PE)(OR:1.47,95%CI:1.37-1.48),arrhythmia(OR:1.41,95%CI:1.38-1.43),atrial fibrillation/flutter(OR:1.61,95%CI:1.58-1.64),cardiac arrest including ventricular tachyarrhythmia(OR:1.63,95%CI:1.46-1.82),and stroke(OR:1.28,95%CI:1.22-1.34)with comparable all-cause mortality and fewer routine discharges(48.4%vs 55.0%)(P<0.001)vs the 2007 cohort.CONCLUSION Colon cancer survivors hospitalized 10 years apart in the United States showed an increased CVD risk with an increased risk of acute cardiovascular events(stroke 28%,PE 47%,arrhythmia 41%,and cardiac arrest 63%).It is vital to regularly screen colon cancer survivors with concomitant CVD risk factors to curtail long-term cardiovascular complications.

静止轴肩搅拌摩擦焊接研究进展及展望

静止轴肩搅拌摩擦焊(SSFSW)作为固相连接领域中搅拌摩擦焊接(FSW)技术的一种重要衍生方法,显著改善了FSW接头表面过热、温度梯度大以及板厚减薄等问题,在轻质合金、低热导率材料、中厚板以及角焊缝等结构焊接中具有巨大的应用潜力。综述了现阶段SSFSW的主要研究进展,涉及SSFSW过程的基本原理、成形特征、微观组织以及力学性能等,以期SSFSW技术形成系统的认知,并展望了其发展前景。

Assessment of the ballistic response of honeycomb sandwich structures subjected to offset and normal impact

In the present study,experimental and numerical investigations were carried out to examine the behavior of sandwich panels with honeycomb cores.The high velocity impact tests were carried out using a compressed air gun.A sharp conical nosed projectile was impacted normally and with some offset distance(20 mm and 40 mm).The deformation,failure mode and energy dissipation characteristics were obtained for both kinds of loading.Moreover,the explicit solver was run in Abaqus to create the finite element model.The numerically obtained test results were compared with the experimental to check the accuracy of the modelling.The numerical result was further employed to obtain strain energy dissipation in each element by externally running user-defined code in Abaqus.Furthermore,the influence of inscribe circle diameter and cell wall and face sheet thickness on the energy dissipation,deformation and failure mode was examined.The result found that ballistic resistance and deformation were higher against offset impact compared to the normal impact loading.Sandwich panel impacted at 40 mm offset distance required 3 m/s and 1.9 m/s more velocity than 0 and 20 mm offset distance.Also,increasing the face sheet and wall thickness had a positive impact on the ballistic resistance in terms of a higher ballistic limit and energy absorption.However,inscribe circle diameter had a negative influence on the ballistic resistance.Also,the geometrical parameters of the sandwich structure had a significant influence on the energy dissipation in the different deformation directions.The energy dissipation in plastic work was highest for circumferential direction,regardless of impact condition followed by tangential,radial and axial directions.

Assessing the Bonding Interface Characteristics and Mechanical Properties of Bobbin Tool Friction Stir Welded Dissimilar Aluminum Alloy Joints

This study focuses on the bonding interface characteristics and mechanical properties of the bobbin tool friction stir welded dissimilar AA6056 and AA2219 aluminum alloy joints using diff erent welding speeds.Voids arise solely in the stir zone at the AA2219 side.A distinct boundary with limited material mixing develops at the middle section of the bonding interface,while excellent material mixing with an irregularly jagged pattern forms at the top and bottom sections of the bonding interface.Increasing the welding speed,the material mixing is rarely changed at the middle section in comparison with the bottom section.Furthermore,a small diff erence between Guinier–Preston dissolution and Q phase precipitation leads to rare change of hardness in the heat aff ected zone(HAZ)at the AA6056 side.The increased hardness of the HAZ at the AA2219 side is attributed to avoidance of the dissolution ofθ’’phase precipitates.A maximum tensile strength of 181 MPa is obtained at 300 mm min-1.Fractures occur at the AA6056 side near the top and bottom surfaces and at the bonding interface in the middle section of the joints.The regions close to the top and bottom surfaces of the joints show a better ductility.

Review of the crushing response of collapsible tubular structures

Studies on determining and analyzing the crushing response of tubular structures are of significant interest,primarily due to their relation to safety.Several aspects of tubular structures,such as geometry,material,configuration,and hybrid structure,have been used as criteria for evaluation.In this review,a comprehensive analysis of the important findings of extensive research on understanding the crushing response of thin-walled tubular structures is presented.Advancements in thin-walled structures,including multi-cell tube,honeycomb and foam-filled,multi wall,and functionally graded thickness tubes,are also discussed,focusing on their energy absorption ability.An extensive review of experimentation and numerical analysis used to extract the deformation behavior of materials,such as aluminum and steel,against static and dynamic loadings are also provided.Several tube shapes,such as tubes of uniform and nonuniform(tapered)cross sections of circular,square,and rectangular shapes,have been used in different studies to identify their efficacy.Apart from geometric and loading parameters,the effects of fabrication process,heat treatment,and triggering mechanism on initiating plastic deformation,such as cutouts and grooves,on the surface of tubular structures are discussed.

Synergistic effect of organic and inorganic nano fillers on the dielectric and mechanical properties of epoxy composites

Titanium oxide TiO;/epoxy and TiO;with detonation nano-diamond（DND）/epoxy nanocomposites were prepared by using ultrasonication method. TiO;and DND particles as reinforcement species and epoxy as matrix were used to produce nanocomposites. The addition of DND particles into TiO;/epoxy composite improved the dielectric and mechanical properties of nanocomposites in significant amount.The dielectric properties of TiO;-DND/epoxy nanocomposite demonstrated increase in permittivity and conductivity after addition of the DND particles. The maximum and minimum reflection losses of TiO;-DND/epoxy nanocomposite for 0.6 and 0.2 wt% DND loading were detected at -14.5 and -1.3 dB,respectively. The flexural and tensile strength of TiO;-DND/epoxy nanocomposites with the addition of 0.4 wt% DNDs were enhanced to 220% and 223%, respectively. Additionally, the energy to break and percent break strain were 3.9 J and 3.86, respectively for 0.4 wt% DND loading in TiO;-DND/epoxy nanocomposite. Therefore, the present work findings claim that DND particles are well suitable to enrich the dispersion of TiO;nanoparticles in epoxy matrix, which develops a strong load transfer interface between the nanoparticles and epoxy matrix and consequently leads to superior properties.