Ribonucleotide reductase(RNR)catalyses the only known de novo pathway for the production of all four deoxyribonucleotides that are required for DNA synthesis1,2.It is essential for all organisms that use DNA as their ...Ribonucleotide reductase(RNR)catalyses the only known de novo pathway for the production of all four deoxyribonucleotides that are required for DNA synthesis1,2.It is essential for all organisms that use DNA as their genetic material and is a current drug target3,4.Since the discovery that iron is required for function in the aerobic,class I RNR found in all eukaryotes and many bacteria,a dinuclear metal site has been viewed as necessary to generate and stabilize the catalytic radical that is essential for RNR activity5-7.展开更多
文摘Ribonucleotide reductase(RNR)catalyses the only known de novo pathway for the production of all four deoxyribonucleotides that are required for DNA synthesis1,2.It is essential for all organisms that use DNA as their genetic material and is a current drug target3,4.Since the discovery that iron is required for function in the aerobic,class I RNR found in all eukaryotes and many bacteria,a dinuclear metal site has been viewed as necessary to generate and stabilize the catalytic radical that is essential for RNR activity5-7.
