Objective To evaluate the spermicidal activity of Passiflora edulis extract on human spermatozoa. Methods Human spermatozoa were incubated with P. edulis extracts and their motility and viability were evaluated; addit...Objective To evaluate the spermicidal activity of Passiflora edulis extract on human spermatozoa. Methods Human spermatozoa were incubated with P. edulis extracts and their motility and viability were evaluated; additionally, the cytotoxic effect of the extracts was evaluated by the tetrazolium bromide （MTT） reduction assay. Results The motility and viability were decreased immediately after treatment with a 21% dilution of the supernatant of the extract of P. edulis （P〈0.01）. No cytatoxic effect of the extracts studied was found on proliferation of MDBK and VERO cells. Conclusion These results may open the way for the use of P. edulis as a spermicidal product with less adverse effects.展开更多
基金WCM was supported by a fellowship from Colciencias, Colombia
文摘Objective To evaluate the spermicidal activity of Passiflora edulis extract on human spermatozoa. Methods Human spermatozoa were incubated with P. edulis extracts and their motility and viability were evaluated; additionally, the cytotoxic effect of the extracts was evaluated by the tetrazolium bromide （MTT） reduction assay. Results The motility and viability were decreased immediately after treatment with a 21% dilution of the supernatant of the extract of P. edulis （P〈0.01）. No cytatoxic effect of the extracts studied was found on proliferation of MDBK and VERO cells. Conclusion These results may open the way for the use of P. edulis as a spermicidal product with less adverse effects.
