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组织内包膜微泡声空化动力学及其力学效应分析 被引量:8
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作者 秦对 邹青钦 +3 位作者 李章勇 王伟 万明习 冯怡 《物理学报》 SCIE EI CAS CSCD 北大核心 2021年第15期170-181,共12页
声空化机械效应是聚焦超声治疗的重要物理机制.以脂类包膜微泡/纳米相变液滴为空化核可显著地增强空化效应,本文耦合空化动力学、组织和脂类包膜黏弹性模型,构建了组织内脂类包膜微泡声空化动力学模型,数值分析了微泡声空化动力学行为... 声空化机械效应是聚焦超声治疗的重要物理机制.以脂类包膜微泡/纳米相变液滴为空化核可显著地增强空化效应,本文耦合空化动力学、组织和脂类包膜黏弹性模型,构建了组织内脂类包膜微泡声空化动力学模型,数值分析了微泡声空化动力学行为以及周围组织内机械应力的时空分布规律,并探究了包膜材料、组织黏弹性和驱动声压等关键参数的影响.包膜和组织黏弹性都将抑制微泡振动,但组织黏弹性的抑制作用更大.组织内机械应力在膨胀阶段为挤压应力,而在收缩阶段和反弹初始阶段为拉伸应力,且应力局部分布于微泡壁附近,随着距离增大而显著减小,其中拉伸应力衰减率明显更大.包膜黏弹性可减小应力,但声压较大时,应力减小可忽略不计.应力随着组织弹性增大而减小,随着组织黏度增大而先增大后减小,随着声压增大而增大.本研究可为进一步阐释聚焦超声治疗中组织机械损伤的内在机制奠定重要理论基础. 展开更多
关键词 气泡动力学 包膜微泡 组织内声空化 空化机械效应
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Monte Carlo Simulation of Scattered Light with Shear Waves Generated by Acoustic Radiation Force for Acousto-Optic Imaging 被引量:3
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作者 LU Ming-Zhu WU Yu-Peng +3 位作者 SHI Yu GUAN Yu-Bo GUO Xiao-Li wan ming-xi 《Chinese Physics Letters》 SCIE CAS CSCD 2012年第12期123-126,共4页
A Monte Carlo method of multiple scattered coherent light with the information of shear wave propagation in scattering media is presented.The established Monte-Carlo algorithm is mainly relative to optical phase varia... A Monte Carlo method of multiple scattered coherent light with the information of shear wave propagation in scattering media is presented.The established Monte-Carlo algorithm is mainly relative to optical phase variations due to the acoustic-radiation-force shear-wave-induced displacements of light scatterers.Both the distributions and temporal behaviors of optical phase increments in probe locations are obtained.Consequently,shear wave speed is evaluated quantitatively.It is noted that the phase increments exactly track the propagations of shear waves induced by focus-ultrasound radiation force.In addition,attenuations of shear waves are demonstrated in simulation results.By using linear regression processing,the shear wave speed,which is set to 2.1 m/s in simulation,is estimated to be 2.18 m/s and 2.35 m/s at time sampling intervals of 0.2 ms and 0.5 ms,respectively. 展开更多
关键词 SHEAR PROPAGATION PHASE
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Propagation of Shear Waves Generated by Acoustic Radiation Force in Nondissipative Inhomogeneous Media 被引量:1
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作者 LU Ming-Zhu LIU Xue-Jin +3 位作者 SHI Yu KANG Yan-Ni GUAN Yu-Bo wan ming-xi 《Chinese Physics Letters》 SCIE CAS CSCD 2012年第1期164-167,共4页
We concentrate on the nondissipative mechanism induced shear wave in inhomogenous tissue.The shear wave equation of radiation force in inhomogeneous media is solved numerically with a finite-difference time-domain met... We concentrate on the nondissipative mechanism induced shear wave in inhomogenous tissue.The shear wave equation of radiation force in inhomogeneous media is solved numerically with a finite-difference time-domain method.A rarely studied nondissipative mechanism of shear displacement due to a smooth medium inhomogeneity is evaluated.It is noted that unlike the dissipative effect,the nondissipative action on a localized inhomogeneity with its hardness parameter changing smoothly along the beam axis,compresses or stretches the focus area.The shear waves in nondissipative inhomogeneous media remain the property of sharp turn with 100% peak positive displacement and 64% peak negative displacement.This action is useful in discerning the water-like lesion. 展开更多
关键词 method. DISSIPATIVE INHOMOGENEOUS
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