目的:探讨理筋拔戳揉捻法治疗肱骨外上髁炎(liater epicondylitis,LE)的临床疗效。方法:自2018年1月至2021年12月采用多中心随机对照研究方法,分别在中国中医科学院望京医院、北京电力医院、北京丰盛骨伤科专科医院收集LE患者192例,采...目的:探讨理筋拔戳揉捻法治疗肱骨外上髁炎(liater epicondylitis,LE)的临床疗效。方法:自2018年1月至2021年12月采用多中心随机对照研究方法,分别在中国中医科学院望京医院、北京电力医院、北京丰盛骨伤科专科医院收集LE患者192例,采用随机数字表法分为治疗组和对照组。治疗组96例,男36例,女60例;年龄28~60(41.20±5.50)岁;病程1~14(5.24±1.35)d;予理筋拔戳揉捻法配合肘关节练功法治疗,隔日1次,治疗2周。对照组96例,男33例,女63例;年龄26~60(43.35±7.75)岁;病程1~14(5.86±1.48)d,予外用扶他林配合护肘关节固定治疗,治疗2周。分别于治疗前及治疗后第1、3、5、7、11、13天比较疼痛视觉模拟评分(visual analogue scale VAS)、美国特种医院评分系统(Hospital for Surgery Scoring System,HSS)、肘关节旋前及旋后角度、腕关节掌屈及背伸角度、肘关节压痛,并比较治疗前及治疗结束后美国特种医院评分系统2(Hospital for Surgery Scoring System2,HSS2)肘关节评分。结果:所有患者获得随访,时间10~14(12.0±1.6)d。治疗组及对照组治疗前VAS分别为(6.83±1.36)、(6.79±1.58)分,末次治疗后降低至(1.49±1.09)、(2.11±1.81)分,其中治疗后第1、3、5、7、9、11、13天,治疗组VAS较对照组明显降低(P<0.05)。两组治疗前HSS评分分别为(61.73±11.00)、(36.47±12.45)分,末次治疗后提高至(94.42±5.90)、(91.44±9.11)分,其中治疗后第1、3、5、7、9、11、13天,治疗组HSS显著高于对照组(P<0.05)。治疗后第5天,治疗组肘关节外旋角度、内旋角度分别为(66.41±12.69)°、(66.35±13.54)°,对照组为(62.08±16.03)°、(61.77±16.35)°;治疗后第7天,治疗组肘关节外旋角度、内旋角度分别为(69.79±12.64)°、(70.02±13.55)°,对照组为(65.28±15.86)°、(65.09±16.67)°,以上时间点治疗组肘关节活动度大于对照组(P<0.05)。治疗后第5天,治疗组腕关节背伸、掌屈角度为(39.43±15.94)°、(46.68±11.10)°,对照组为(38.51±18.49)°、(44.27±13.58)°;治疗后第7天,治疗组腕关节背伸、掌屈角度分别为(42.52±16.50)°、(49.23±10.96)°,对照组为(41.18±20.09)°、(46.64±14.63)°;治疗组腕关节活动度大于对照组(P<0.05)。治疗后第13天,治疗组HSS2为(93.61±6.32)分,高于对照组(92.06±7.94)分(P<0.05)。两组各时间点肘关节压痛值比较,差异无统计学意义(P>0.05)。结论:扶他林外用联合肘部固定和理筋拔戳揉捻手法均能有效改善LE的症状,理筋拔戳揉捻手法较扶他林外用治疗具有止痛时间长和恢复肘关节功能更好的优势。展开更多
腰椎管狭窄症(lumbar spinal stenosis,LSS)是引起神经源性跛行(neurogenic claudication,NC的主要原因,在老年人中较为常见,且发病率有增加的趋势。为了提供更加有效的LSS所致NC的非手术疗法,美国疼痛研究协会(United States Associati...腰椎管狭窄症(lumbar spinal stenosis,LSS)是引起神经源性跛行(neurogenic claudication,NC的主要原因,在老年人中较为常见,且发病率有增加的趋势。为了提供更加有效的LSS所致NC的非手术疗法,美国疼痛研究协会(United States Association for the Study of Pain)于2021年发布了新版循证临床实践指南。在充分研读最新版指南的基础上,结合临床新进展,并与2011年北美脊柱学会(North American Spine Society,NASS)指南(以下简称2011指南)和2019年丹麦卫生管理局(Danish Health Authority,DHA)指南(以下简称2019指南)进行比较,对LSS所致NC的临床诊治进行评述并提出建议。展开更多
Objectve:To investigate the effect and mechanism of Hai Tongpi decoction ointment on analgesic and anti-inflammatory effects in mice after transdermal administration.Methods:The hot plate method and the acetic acid wr...Objectve:To investigate the effect and mechanism of Hai Tongpi decoction ointment on analgesic and anti-inflammatory effects in mice after transdermal administration.Methods:The hot plate method and the acetic acid writhing experiment were used to verify the analgesic effect of Hai tong-pi extract on pain model mice;the xylene-induced auricular swelling model and the carrageenan-induced right foot swelling model were used,combined with the ELISA method to determine the analgesic effect.The levels of TNF-α,IL-1βand IL-6 in the serum of mice were observed.Anti-inflammatory effect of Haitongpi Tang decoction ointment on inflammation model mice.Results:In terms of analgesia,compared with the model group,both the treatment group 1 and the treatment group 2 can significantly prolong the hot plate pain threshold and the latency of the writhing response(P<0.05),and significantly reduce the writhing in the mice.The number of times(P<0.001),and the effect of process 1 is more obvious(P<0.05);In terms of antiinflammatory,compared with the blank group,the swelling degree and swelling rate of the right hind paw of the mice in the model group were significantly increased(P<0.01),indicating that the acute inflammation model was successfully established in the mice.Compared with the model group,both the process group 1 and the process group 2 can significantly reduce the swelling degree and swelling rate of the mice feet(P<0.05),and reduce the auricle swelling degree of the mice,and increase the swelling inhibition rate(P<0.05),and the effective effect of process 1 group was more significant(P<0.05).At the same time,compared with the blank group,the contents of TNF-α,IL-1βand IL-6 in the model group were significantly increased(P<0.01).Compared with the process group 2,the process group 1 had a more significant decrease in the content of IL-1β(P<0.05),and IL-6 content of the two had no statistical difference(P>0.05).Conclusion:The Hai tong-pi decoction ointment prepared by two different processes have good analgesic and antiinflammatory effects on mice after transdermal administration.inflammatory cytokine expression.The anti-inflammatory and analgesic effect of process group 1 was better than that of process group 2,which may be related to the separate extraction and storage of volatile oil of traditional Chinese medicine,which ensured the long-term pharmacological activity of volatile oil.展开更多
文摘目的:探讨理筋拔戳揉捻法治疗肱骨外上髁炎(liater epicondylitis,LE)的临床疗效。方法:自2018年1月至2021年12月采用多中心随机对照研究方法,分别在中国中医科学院望京医院、北京电力医院、北京丰盛骨伤科专科医院收集LE患者192例,采用随机数字表法分为治疗组和对照组。治疗组96例,男36例,女60例;年龄28~60(41.20±5.50)岁;病程1~14(5.24±1.35)d;予理筋拔戳揉捻法配合肘关节练功法治疗,隔日1次,治疗2周。对照组96例,男33例,女63例;年龄26~60(43.35±7.75)岁;病程1~14(5.86±1.48)d,予外用扶他林配合护肘关节固定治疗,治疗2周。分别于治疗前及治疗后第1、3、5、7、11、13天比较疼痛视觉模拟评分(visual analogue scale VAS)、美国特种医院评分系统(Hospital for Surgery Scoring System,HSS)、肘关节旋前及旋后角度、腕关节掌屈及背伸角度、肘关节压痛,并比较治疗前及治疗结束后美国特种医院评分系统2(Hospital for Surgery Scoring System2,HSS2)肘关节评分。结果:所有患者获得随访,时间10~14(12.0±1.6)d。治疗组及对照组治疗前VAS分别为(6.83±1.36)、(6.79±1.58)分,末次治疗后降低至(1.49±1.09)、(2.11±1.81)分,其中治疗后第1、3、5、7、9、11、13天,治疗组VAS较对照组明显降低(P<0.05)。两组治疗前HSS评分分别为(61.73±11.00)、(36.47±12.45)分,末次治疗后提高至(94.42±5.90)、(91.44±9.11)分,其中治疗后第1、3、5、7、9、11、13天,治疗组HSS显著高于对照组(P<0.05)。治疗后第5天,治疗组肘关节外旋角度、内旋角度分别为(66.41±12.69)°、(66.35±13.54)°,对照组为(62.08±16.03)°、(61.77±16.35)°;治疗后第7天,治疗组肘关节外旋角度、内旋角度分别为(69.79±12.64)°、(70.02±13.55)°,对照组为(65.28±15.86)°、(65.09±16.67)°,以上时间点治疗组肘关节活动度大于对照组(P<0.05)。治疗后第5天,治疗组腕关节背伸、掌屈角度为(39.43±15.94)°、(46.68±11.10)°,对照组为(38.51±18.49)°、(44.27±13.58)°;治疗后第7天,治疗组腕关节背伸、掌屈角度分别为(42.52±16.50)°、(49.23±10.96)°,对照组为(41.18±20.09)°、(46.64±14.63)°;治疗组腕关节活动度大于对照组(P<0.05)。治疗后第13天,治疗组HSS2为(93.61±6.32)分,高于对照组(92.06±7.94)分(P<0.05)。两组各时间点肘关节压痛值比较,差异无统计学意义(P>0.05)。结论:扶他林外用联合肘部固定和理筋拔戳揉捻手法均能有效改善LE的症状,理筋拔戳揉捻手法较扶他林外用治疗具有止痛时间长和恢复肘关节功能更好的优势。
文摘腰椎管狭窄症(lumbar spinal stenosis,LSS)是引起神经源性跛行(neurogenic claudication,NC的主要原因,在老年人中较为常见,且发病率有增加的趋势。为了提供更加有效的LSS所致NC的非手术疗法,美国疼痛研究协会(United States Association for the Study of Pain)于2021年发布了新版循证临床实践指南。在充分研读最新版指南的基础上,结合临床新进展,并与2011年北美脊柱学会(North American Spine Society,NASS)指南(以下简称2011指南)和2019年丹麦卫生管理局(Danish Health Authority,DHA)指南(以下简称2019指南)进行比较,对LSS所致NC的临床诊治进行评述并提出建议。
基金China Academy of Chinese Medical Sciences"predominant diseasehospital preparation-new drug"research and development project(NO.ZZ15-XY-PT-12)。
文摘Objectve:To investigate the effect and mechanism of Hai Tongpi decoction ointment on analgesic and anti-inflammatory effects in mice after transdermal administration.Methods:The hot plate method and the acetic acid writhing experiment were used to verify the analgesic effect of Hai tong-pi extract on pain model mice;the xylene-induced auricular swelling model and the carrageenan-induced right foot swelling model were used,combined with the ELISA method to determine the analgesic effect.The levels of TNF-α,IL-1βand IL-6 in the serum of mice were observed.Anti-inflammatory effect of Haitongpi Tang decoction ointment on inflammation model mice.Results:In terms of analgesia,compared with the model group,both the treatment group 1 and the treatment group 2 can significantly prolong the hot plate pain threshold and the latency of the writhing response(P<0.05),and significantly reduce the writhing in the mice.The number of times(P<0.001),and the effect of process 1 is more obvious(P<0.05);In terms of antiinflammatory,compared with the blank group,the swelling degree and swelling rate of the right hind paw of the mice in the model group were significantly increased(P<0.01),indicating that the acute inflammation model was successfully established in the mice.Compared with the model group,both the process group 1 and the process group 2 can significantly reduce the swelling degree and swelling rate of the mice feet(P<0.05),and reduce the auricle swelling degree of the mice,and increase the swelling inhibition rate(P<0.05),and the effective effect of process 1 group was more significant(P<0.05).At the same time,compared with the blank group,the contents of TNF-α,IL-1βand IL-6 in the model group were significantly increased(P<0.01).Compared with the process group 2,the process group 1 had a more significant decrease in the content of IL-1β(P<0.05),and IL-6 content of the two had no statistical difference(P>0.05).Conclusion:The Hai tong-pi decoction ointment prepared by two different processes have good analgesic and antiinflammatory effects on mice after transdermal administration.inflammatory cytokine expression.The anti-inflammatory and analgesic effect of process group 1 was better than that of process group 2,which may be related to the separate extraction and storage of volatile oil of traditional Chinese medicine,which ensured the long-term pharmacological activity of volatile oil.