Objective To evaluate the possible association between radon exposure and kidney cancer. Methods We performed a systematic review and a meta-analysis based on random effect models to provide a pooled association measu...Objective To evaluate the possible association between radon exposure and kidney cancer. Methods We performed a systematic review and a meta-analysis based on random effect models to provide a pooled association measure. Results We subjected 8 studies(overall relative risks and 95% confidence intervals: 1.01, 0.72 to 1.43, I2= 64.4%) to meta-analysis. Subgroup analysis revealed a marginally significant association between radon exposure and kidney cancer in studies conducted in Europe. Two population-based studies provided no evidence for the increased risk of kidney cancer in the general population. Conclusion The association between radon and kidney cancer remains unclear but cannot be excluded because of its biological plausibility and the limited number and quality of existing studies. Additional data from the general population and well-designed miner cohort studies are needed to reveal the real relationship between radon exposure and kidney cancer.展开更多
This study was conducted to elucidate the reproductive effect of NP on testis,epididymis and epididymal sperm in vivo.Adult male SpragueDawley rats were gavaged with NP at 0,40,100,or 250 mg/kg body weight（bw） on al...This study was conducted to elucidate the reproductive effect of NP on testis,epididymis and epididymal sperm in vivo.Adult male SpragueDawley rats were gavaged with NP at 0,40,100,or 250 mg/kg body weight（bw） on alternate days for 90 d.The results showed that oral administration of NP may damage the structure and function of testis,induce apoptosis and oxidative stress in epididymis or even have cytotoxic effects on epididymal sperm.展开更多
基金supported by the National Natural Scientific Foundation of China [Grant ref:81673126,81703205]China Postdoctoral Science Foundation [Grant ref:2017T100402]+3 种基金Youth Foundation of Jiangsu Province [Grant ref:BK20160333]Natural Science Research in Colleges and Universities of Jiangsu Province [Grant ref:16KJB330008]China Postdoctoral Science Foundation [Grant ref:2016M600440]Postdoctoral Science Foundation of Jiangsu Province [Grant ref:1601079C]
文摘Objective To evaluate the possible association between radon exposure and kidney cancer. Methods We performed a systematic review and a meta-analysis based on random effect models to provide a pooled association measure. Results We subjected 8 studies(overall relative risks and 95% confidence intervals: 1.01, 0.72 to 1.43, I2= 64.4%) to meta-analysis. Subgroup analysis revealed a marginally significant association between radon exposure and kidney cancer in studies conducted in Europe. Two population-based studies provided no evidence for the increased risk of kidney cancer in the general population. Conclusion The association between radon and kidney cancer remains unclear but cannot be excluded because of its biological plausibility and the limited number and quality of existing studies. Additional data from the general population and well-designed miner cohort studies are needed to reveal the real relationship between radon exposure and kidney cancer.
基金supported by‘A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)’
文摘This study was conducted to elucidate the reproductive effect of NP on testis,epididymis and epididymal sperm in vivo.Adult male SpragueDawley rats were gavaged with NP at 0,40,100,or 250 mg/kg body weight（bw） on alternate days for 90 d.The results showed that oral administration of NP may damage the structure and function of testis,induce apoptosis and oxidative stress in epididymis or even have cytotoxic effects on epididymal sperm.
