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外周血GDF-15和β2-MG表达水平与冠心病介入治疗患者术后支架内再狭窄的关系 被引量:9
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作者 蔡宇豪 王崇丽 江丽丽 《临床和实验医学杂志》 2020年第21期2278-2281,共4页
目的探究外周血生长分化因子-15(GDF-15)、β2微球蛋白(β2-MG)表达水平与冠心病经皮冠状动脉介入治疗术(PCI)患者术后支架内再狭窄(ISR)的关系。方法回顾性选取2017年1月到2019年5月青岛市第八人民医院收治的104例冠心病行PCI治疗后发... 目的探究外周血生长分化因子-15(GDF-15)、β2微球蛋白(β2-MG)表达水平与冠心病经皮冠状动脉介入治疗术(PCI)患者术后支架内再狭窄(ISR)的关系。方法回顾性选取2017年1月到2019年5月青岛市第八人民医院收治的104例冠心病行PCI治疗后发生ISR患者的临床资料,并作为ISR组。另选我院同期收治的31例冠心病行PCI治疗后未发生ISR患者作为对照组。根据Gensini总积分分为低分组(<30分,n=39)、中分组(30~60分,n=34)、高分组(>60分,n=31)。按患者冠状动脉狭窄支数分为一支组(1支狭窄支,n=41)、双支组(2支狭窄支,n=33)和多支组(3支以上狭窄支,n=30)。收集ISR组和对照组患者临床资料,检测外周血GDF-15、β2-MG表达水平。采用多因素Logistic回归分析影响患术后ISR的高危因素。分析不同Gensini积分组、不同狭窄支组血清GDF-15、β2-MG表达水平。分析血清GDF-15、β2-MG与术后ISR关系。结果ISR组糖化血红蛋白(Hb A1c)、低密度脂蛋白胆固醇(LDL-C)、超敏C反应蛋白(hs-CRP)、GDF-15、β2-MG水平分别为(8.14±1.22)mmol/L、(3.92±0.43)mmol/L、(13.94±1.68)mg/L、(1875.36±320.75)ng/L、(2.59±0.36)mg/L,高于对照组[(8.12±1.16)mmol/L、(3.72±0.32)mmol/L、(10.25±1.36)mg/L、(1305.24±294.28)ng/L、(1.86±0.27)mg/L],差异具有统计学意义(P<0.05)。多因素logisitic回归分析显示,血清GDF-15、β2-MG、hs-CRP是影响患者术后ISR的独立危险因素(OR=3.131、4.692、4.155,95%CI区间为1.877~9.621、3.342~18.074、2.217~14.286,P<0.05)。外周血GDF-15、β2-MG表达水平在Gensni积分低分组、中分组、高分组中逐渐升高,差异具有统计学意义(P<0.05);外周血β2-MG、GDF-15表达水平在动脉狭窄支中单支组、双支组、多支组中逐渐升高,差异具有统计学意义(P<0.05)。Spearman相关性分析显示,外周血β2-MG、GDF-15水平与狭窄支数和Gensni积分均呈正相关(r=0.815、0.824;0.713、0.623,P<0.05)。结论外周血GDF-15、β2-MG表达水平是术后发生ISR的高危因素,且与冠心病介入治疗患者狭窄支数、Gensni积分相关。 展开更多
关键词 冠心病 生长分化因子-15 β2微球蛋白 经皮冠状动脉介入治疗术 术后支架内再狭窄
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Removal of a broken guide wire entrapped in a fractured femoral neck
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作者 ZHU Qing-hua YE Tian-wen +2 位作者 GUO Yong-fei wang chong-li CHEN Ai-min 《Chinese Journal of Traumatology》 CAS CSCD 2013年第4期237-239,共3页
Guide wire plays an important role in the fixation of femoral neck fracture with dynamic hip screw (DHS). Breakage of a guide wire during operation is a very rare condition. We met such a dilemma in DHS fixation of ... Guide wire plays an important role in the fixation of femoral neck fracture with dynamic hip screw (DHS). Breakage of a guide wire during operation is a very rare condition. We met such a dilemma in DHS fixation of a 54-year-old male patient who sustained Garden type IV frac- ture of the right femoral neck. The distal end of the guide wire broke and was entrapped in the fractured femoral neck. We tried to get the broken part out by a cannulated drill. Reaming was started with the cannulated drill slowly rotat- ing arotmd the guide K-wire until the reamer fully contained the target under fluoroscope. A bone curette was used to get the broken wire out but failed, so we had to use the cannuated drill to dredge this bone tunnel. Finally the bro-ken wire end was taken out, mixed with blood and bone fragments. Through the existing drilling channel, DHS fixa- tion was easily finished. The patient had an uneventful re- covery without avascular necrosis of femoral head or non- union of the fracture at one year's follow-up. A few methods can be adopted to deal with the broken guide wire. The way used in our case is less invasive but technically challenging. When the guide wire is properly positioned, this method is very practical and useful. 展开更多
关键词 Femoral neck fractures Bones wires COMPLICATIONS
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