Persistent hepatitis B virus （HBV） infection is the most important reason for chronic hepatitis B,hepatic cirrhosis, and hepatocellular carcinoma. T lymphocytes, including CD4^＋ and CD8^＋ T cells, are major compos...Persistent hepatitis B virus （HBV） infection is the most important reason for chronic hepatitis B,hepatic cirrhosis, and hepatocellular carcinoma. T lymphocytes, including CD4^＋ and CD8^＋ T cells, are major composition of host cellular immunity. Furthermore, CD8^＋ cells play a primary role in host immune reaction of anti-tumor and anti-infection. It has been confirmed that HBV infection leads to disorder of cellular immune function in patients, especially disorder in regulative function of T lymphocyte subgroups and cytokine. It has been paid more attention to the expression of HLA class I on hepatocytes infected by HBV and tumor cells, but less to the expression of HLA class I on peripheral blood lymphocytes in the past. In this study, we evaluated the expression of HLA class I and II on peripheral blood lymphocytes in patients with chronic hepatitis B, hepatic cirrhosis, and hepatocellular carcinoma and tried to provide new thought for the mechanism of disorder of celluar immunity.展开更多
基金This study was supported by a grant from the Science and Technology Department of Shandong Province (No. 2002BB1CJA8).
文摘Persistent hepatitis B virus （HBV） infection is the most important reason for chronic hepatitis B,hepatic cirrhosis, and hepatocellular carcinoma. T lymphocytes, including CD4^＋ and CD8^＋ T cells, are major composition of host cellular immunity. Furthermore, CD8^＋ cells play a primary role in host immune reaction of anti-tumor and anti-infection. It has been confirmed that HBV infection leads to disorder of cellular immune function in patients, especially disorder in regulative function of T lymphocyte subgroups and cytokine. It has been paid more attention to the expression of HLA class I on hepatocytes infected by HBV and tumor cells, but less to the expression of HLA class I on peripheral blood lymphocytes in the past. In this study, we evaluated the expression of HLA class I and II on peripheral blood lymphocytes in patients with chronic hepatitis B, hepatic cirrhosis, and hepatocellular carcinoma and tried to provide new thought for the mechanism of disorder of celluar immunity.
