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越鞠甘麦大枣汤调节小鼠海马PKA-CREB-BDNF信号通路的抗抑郁作用(英文) 被引量:15
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作者 张艺 王江荟 +8 位作者 张海楼 沈琴琴 孙焱 王春秀 薛文达 聂春莹 盛莉 陈刚 王薇 《南京中医药大学学报》 CAS CSCD 北大核心 2018年第6期572-577,共6页
目的探讨越鞠甘麦大枣汤(YG)的抗抑郁功效及其与PKA-CREB-BDNF信号通路的关联。方法强迫游泳(FST)检测越鞠甘麦大枣汤单次给药后抗抑郁的时效性。慢性不可预测模型(CMS)进一步检测越鞠甘麦大枣汤在抑郁模型上的抗抑郁作用。蛋白印迹表... 目的探讨越鞠甘麦大枣汤(YG)的抗抑郁功效及其与PKA-CREB-BDNF信号通路的关联。方法强迫游泳(FST)检测越鞠甘麦大枣汤单次给药后抗抑郁的时效性。慢性不可预测模型(CMS)进一步检测越鞠甘麦大枣汤在抑郁模型上的抗抑郁作用。蛋白印迹表达法检测越鞠甘麦大枣汤单次给药30min和24h后海马中PKA、CREB、BDNF的蛋白表达。结果YG在FST中显示出持久的抗抑郁潜力,并且快速逆转了慢性应激小鼠的抑郁样行为。在慢性小鼠模型中,海马中PKA,CREB和BDNF的表达显著上调。结论越鞠甘麦大枣汤(YG)显示出快速和持久的抗抑郁样作用,其抗抑郁功能与PKACREB-BNDF通路有关。 展开更多
关键词 越鞠甘麦大枣汤 抗抑郁样作用 PKA CREB BDNF
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Body Mass Index and Hypertension Hemodynamic Subtypes in Yi Farmers and Migrants 被引量:1
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作者 SHAN Guang Liang WEI Da Ying +8 位作者 wang chun xiu ZHANG Jian Hua wang Bin MA Ming Ju PAN Li YU Tao XUE Fang wang Ping WU Zheng Lai 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2012年第1期53-60,共8页
Objective To examine the relationship between overweight or obesity and the risk of the various hypertension hemodynamic subtypes in Yi farmers and migrants. Methods A cross-sectional study of 2 358 Yi farmers and 2 3... Objective To examine the relationship between overweight or obesity and the risk of the various hypertension hemodynamic subtypes in Yi farmers and migrants. Methods A cross-sectional study of 2 358 Yi farmers and 2 392 Yi migrants was carried out in the Liangshan Yi autonomous prefecture, Sichuan, China in 2007. Results The standardized prevalence of overweight in female Yi farmers (6.22%) was higher than in males (3.25%), whereas in Yi migrants 32.56% of males and 28.78% of females were overweight. The standardized prevalence of obesity was 0 and 0.62% in male and female Yi farmers, compared to 3.91% and 5.57% in male and female Yi migrants, respectively. For both genders the standardized prevalence of ISH, IDH, and SDH was higher in Yi migrants than Yi farmers. Overweight and obese Yi men and women had a higher risk for IDH and SDH (P〈O.002) than non-overweight/obese individuals. However, an association of overweight or obesity with ISH was observed only in men. Conclusion Yi migrants have substantially higher proportion of overweight and obese individuals, as well as individuals affected by ISH, IDH, and SDH, than do Yi farmers. Overweight and obesity are significant risk factors for the development of hypertension in Yi people. 展开更多
关键词 Body mass index (BMI) OVERWEIGHT Obesity HYPERTENSION Ethnic Yi MIGRANT China
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