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红景天甙干预可改善慢性间断性缺氧模型小鼠的肺损伤 被引量:6
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作者 皇甫志敏 徐倩 +5 位作者 王晓 王恩平 冯玥 曾娟 朱锐 赵春玲 《中国组织工程研究》 CAS 北大核心 2019年第31期5036-5040,共5页
背景:阻塞性睡眠呼吸暂停低通气综合征和慢性阻塞性肺疾病是呼吸系统常见疾病,二者并存发生率高,临床上称之为"重叠综合征",慢性间断性缺氧是重叠综合征的基本病变过程。目的:探讨红景天甙对慢性间断性缺氧小鼠细胞凋亡和氧... 背景:阻塞性睡眠呼吸暂停低通气综合征和慢性阻塞性肺疾病是呼吸系统常见疾病,二者并存发生率高,临床上称之为"重叠综合征",慢性间断性缺氧是重叠综合征的基本病变过程。目的:探讨红景天甙对慢性间断性缺氧小鼠细胞凋亡和氧化应激肺损伤的作用机制。方法:实验项目经西南医科大学动物实验伦理委员会批准。取野生型C57BL/6雄性小鼠随机分为正常对照组、红景天甙组、慢性间断性缺氧组、慢性间断性缺氧+红景天甙组,后两组模拟慢性间断性缺氧模型:即将小鼠放入缺氧舱,调节初始氧浓度8%-10%维持1min后迅速转为常氧(19%-21%)持续2min为一个完整循环,每天循环8 h,连续30 d。缺氧当天起红景天甙组、慢性间断性缺氧+红景天甙组小鼠给予红景天甙50 mg/(kg·d)灌胃处理连续30 d。光镜下观察肺组织病理变化;化学荧光法定量、定性检测小鼠肺组织氧自由基活性;Western-blot法检测肺组织凋亡相关蛋白半胱氨酸天冬氨酸蛋白酶3(caspase-3)、Bax、Bcl-2水平及Bax/Bcl-2比值。结果与结论:(1)小鼠发生慢性间断性缺氧时激活肺氧化应激途径并启动细胞凋亡,表现为与正常对照组相比,慢性间断性缺氧组病理损伤显著,肺动脉管壁增厚,肺泡大小不均,活性氧活性升高,Bax/Bcl-2比值、caspase-3蛋白水平升高(P<0.05);而给予红景天甙处理可有效改善慢性间断性缺氧造成的小鼠肺损伤,与慢性间断性缺氧组相比,慢性间断性缺氧+红景天甙组肺病理损伤减轻,活性氧活性降低、凋亡蛋白Bax/Bcl-2比值、caspase-3水平下降(P <0.05);正常对照组与红景天甙组各项指标无明显差异(P> 0.05);(2)结果说明,红景天甙可以通过抑制氧化应激反应和细胞凋亡途径改善小鼠慢性间断性缺氧肺损伤。 展开更多
关键词 红景天甙 慢性间断性缺氧 氧化应激 凋亡 活性氧
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先天性心脏病外科手术评估系统研究进展
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作者 王恩平 罗书画 安琪 《中国胸心血管外科临床杂志》 CSCD 北大核心 2024年第4期613-620,共8页
先天性心脏病的外科手术难易程度差异较大,为确保手术安全性和最大化患者的手术获益,既往已有多种先天性心脏病手术难度评分系统,用于评估不同难易程度的外科手术风险。心脏解剖畸形的完全矫治是常见的手术难题,目前研究表明矫治效果与... 先天性心脏病的外科手术难易程度差异较大,为确保手术安全性和最大化患者的手术获益,既往已有多种先天性心脏病手术难度评分系统,用于评估不同难易程度的外科手术风险。心脏解剖畸形的完全矫治是常见的手术难题,目前研究表明矫治效果与患者围手术期死亡率和术后并发症的发生密切相关,提出了关于心脏解剖畸形矫治程度的新型评分体系。因此,本文对已有的文献进行综述,探讨先天性心脏病外科手术的不同评估方法,从而优化先天性心脏病外科手术评估系统,提高手术质量,改善患者预后。 展开更多
关键词 先天性心脏病 外科手术评估系统 手术技术表现 残余畸形 综述
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Effect of TMGa flux on GaN films deposited on Ti coated on glass substrates at low temperature 被引量:2
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作者 wang enping BIAN JiMing +5 位作者 QIN FuWen ZHANG Dong LIU YueMei ZHAO Yue DUAN ZhongWei wang Shuai 《Chinese Science Bulletin》 SCIE EI CAS 2013年第30期3617-3623,共7页
Highly c-axis-oriented GaN films were deposited on Ti coated glass substrates using low temperature electron cyclotron resonance plasma enhanced metal organic chemical vapor deposition system(ECR-PEMOCVD)with trimethy... Highly c-axis-oriented GaN films were deposited on Ti coated glass substrates using low temperature electron cyclotron resonance plasma enhanced metal organic chemical vapor deposition system(ECR-PEMOCVD)with trimethyl gallium(TMGa)as gallium source.The influence of TMGa flux on the properties of GaN films were systematically investigated by reflection high energy electron diffraction(RHEED),X-ray diffraction analysis(XRD),atomic force microscopy(AFM)and Raman scattering.The GaN film with small surface roughness and high c-axis preferred orientation was successfully achieved at the optimized TMGa flux of 1.0 sccm.The ohmic contact characteristic between GaN and Ti layer was clearly demonstrated by the near-linear current-voltage(I-V)curve.The GaN/Ti/glass structure has great potential to dramatically improve the scalability and reduce the cost of solid-state lighting light emitting diodes. 展开更多
关键词 GAN薄膜 玻璃基板 薄膜沉积 钛涂层 流量 ECR-PEMOCVD 低温 化学气相沉积系统
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Robust stabilization of the system family
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作者 wang enping HUANG Lin GENG Zhiyong 《Chinese Science Bulletin》 SCIE EI CAS 2000年第9期802-806,共5页
The problem of robust stabilization of a system family is studied here. A sufficient condition for the existence of a robust controller is presented under the assumption that there are perturbations both in the numera... The problem of robust stabilization of a system family is studied here. A sufficient condition for the existence of a robust controller is presented under the assumption that there are perturbations both in the numerator and in the denominator of the nominal system. This condition can be given by an inequality that is satisfied by the coefficient vectors of the perturbed polynomials. Based on this, the robust controller family stabilizing the system family can be obtained. Therefore, the condition has the advantages of easy computing and further satisfying other required properties. 展开更多
关键词 system FAMILY ROBUST STABILIZATION ROBUST controller.
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D-SThBILITY TESTING FOR THE INTERVALMATRIX FAMILY
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作者 wang enping GENG Zhiyong(Institute Of Systems Science, Academia Sinica, Beijing 100080, China) 《Systems Science and Mathematical Sciences》 SCIE EI CSCD 1998年第3期218-226,共9页
This paper is concerned with the problem of D-stability testing for the interval matrix family. First, a nonlinearly or affine multilinearly parametrized interval polynomial family is considered. If the mapping from t... This paper is concerned with the problem of D-stability testing for the interval matrix family. First, a nonlinearly or affine multilinearly parametrized interval polynomial family is considered. If the mapping from the parameter space to the coefficient space can be expressed as an affine linear mapping of at least two variables, then it is shown that the D-stability of the family is equivalent to that of its low dimensional boundaries. In light of this result, it is proved that to determine the D-stability of an interval matrix family,it suffices to check its n!2n(n-1) n-dimensional exposed faces. Finally the results obtained are extended to the case where the rows or the columns of the matrix family are perturbed independently in different polytopes, and a result analogous to that in the interval case is obtained. 展开更多
关键词 Robust D-STABILITY INTERVAL MATRICES
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