创新型人才培养是当前我国高等教育的重要任务之一,大学生科研训练计划(Student Research Training Program,简称SRTP)是提高大学生创新能力的重要途径。将OBE教育理念有机融入SRTP项目实施过程中,能发挥该理念的最大优势。文章通过探...创新型人才培养是当前我国高等教育的重要任务之一,大学生科研训练计划(Student Research Training Program,简称SRTP)是提高大学生创新能力的重要途径。将OBE教育理念有机融入SRTP项目实施过程中,能发挥该理念的最大优势。文章通过探索分析宁夏大学自2016年开展SRTP项目以来的实施成效与问题,借鉴国内外高校开展SRTP项目的成功经验,结合区域特色,以期完善以成果导向为任务驱动的SRTP培养模式,助力学校“创新、创意、创业”全面发展。展开更多
The entity and symbolic fraction comparison tasks separating identification and semantic access stages based on event-related potential technology were used to investigate neural differences between fraction and decim...The entity and symbolic fraction comparison tasks separating identification and semantic access stages based on event-related potential technology were used to investigate neural differences between fraction and decimal strategies in magnitude processing of nonsymbolic entities and symbolic numbers.The experimental results show that continuous entities elicit stronger left-lateralized anterior N2 in decimals,while discretized ones elicit more significant right-lateralized posterior N2 in fractions during the identification stage.On the other hand,decimals elicit stronger N2 over the left-lateralized fronto-central sites while fractions elicit the more profound P2 over the right-lateralized fronto-central sites and N2 at biparietal regions during the semantic access stage.Hence,for nonsymbolic entity processing,alignments of decimals and continuous entities activate the phonological network,while alignments of fractions and discretized entities trigger the visuospatial regions.For symbolic numbers processing,exact strategies with rote arithmetic retrieval in verbal format are used in decimal processing,while approximate strategies with complex magnitude processing in a visuospatial format are used in fraction processing.展开更多
A novel framework is proposed to obtain physiologically meaningful features for Alzheimer's disease(AD)classification based on sparse functional connectivity and non-negative matrix factorization.Specifically,the ...A novel framework is proposed to obtain physiologically meaningful features for Alzheimer's disease(AD)classification based on sparse functional connectivity and non-negative matrix factorization.Specifically,the non-negative adaptive sparse representation(NASR)method is applied to compute the sparse functional connectivity among brain regions based on functional magnetic resonance imaging(fMRI)data for feature extraction.Afterwards,the sparse non-negative matrix factorization(sNMF)method is adopted for dimensionality reduction to obtain low-dimensional features with straightforward physical meaning.The experimental results show that the proposed framework outperforms the competing frameworks in terms of classification accuracy,sensitivity and specificity.Furthermore,three sub-networks,including the default mode network,the basal ganglia-thalamus-limbic network and the temporal-insular network,are found to have notable differences between the AD patients and the healthy subjects.The proposed framework can effectively identify AD patients and has potentials for extending the understanding of the pathological changes of AD.展开更多
The paper intfoduces a PC-DSP based real-time digital simulator which is portable in size and aimed at the closed-loop testing of various types of protective relays for their design and application. The simulator can ...The paper intfoduces a PC-DSP based real-time digital simulator which is portable in size and aimed at the closed-loop testing of various types of protective relays for their design and application. The simulator can be widely used in not only concerning utilities but also manufacturers and research / certification institutes because of its many functions. The hardware architecture and software implementation of the simulator are described. The main features and functions of the simulator are also展开更多
A series of novel uracil and 5-fluorouracil-l-yl-acetic acid-colchicine derivatives（6a--6n） was synthe- sized via coupling and 5-fluorouracil（5-FU） with C-10 analogues of colchicine. The antitumor activities of th...A series of novel uracil and 5-fluorouracil-l-yl-acetic acid-colchicine derivatives（6a--6n） was synthe- sized via coupling and 5-fluorouracil（5-FU） with C-10 analogues of colchicine. The antitumor activities of the target compounds against human hepatocellular earcinoma（BEL7402） cells, human ovary carcinoma（A2780） cells, human lung adenocarcinoma（A549） cells and human breast carcinoma（MCF7） cells were tested in vitro, and the structure-activity relationship（SAR） of the compounds was also studied. The bioassay results demonstrate that most of the tested compounds display significant activity and particularly, compounds 6a, 6e, 6h and 61 show more potent cytotoxic activities than 5-fluorouracil and colchicine. The results show that the new derivatives of colchicine are potential suppressors on human cancer.展开更多
文摘创新型人才培养是当前我国高等教育的重要任务之一,大学生科研训练计划(Student Research Training Program,简称SRTP)是提高大学生创新能力的重要途径。将OBE教育理念有机融入SRTP项目实施过程中,能发挥该理念的最大优势。文章通过探索分析宁夏大学自2016年开展SRTP项目以来的实施成效与问题,借鉴国内外高校开展SRTP项目的成功经验,结合区域特色,以期完善以成果导向为任务驱动的SRTP培养模式,助力学校“创新、创意、创业”全面发展。
基金The National Natural Science Foundation of China(No.62077013,61773114)the Jiangsu Provincial Innovation Project for Scientific Research of Graduate Students in Universities(No.KYCX17_0160).
文摘The entity and symbolic fraction comparison tasks separating identification and semantic access stages based on event-related potential technology were used to investigate neural differences between fraction and decimal strategies in magnitude processing of nonsymbolic entities and symbolic numbers.The experimental results show that continuous entities elicit stronger left-lateralized anterior N2 in decimals,while discretized ones elicit more significant right-lateralized posterior N2 in fractions during the identification stage.On the other hand,decimals elicit stronger N2 over the left-lateralized fronto-central sites while fractions elicit the more profound P2 over the right-lateralized fronto-central sites and N2 at biparietal regions during the semantic access stage.Hence,for nonsymbolic entity processing,alignments of decimals and continuous entities activate the phonological network,while alignments of fractions and discretized entities trigger the visuospatial regions.For symbolic numbers processing,exact strategies with rote arithmetic retrieval in verbal format are used in decimal processing,while approximate strategies with complex magnitude processing in a visuospatial format are used in fraction processing.
基金The Foundation of Hygiene and Health of Jiangsu Province(No.H2018042)the National Natural Science Foundation of China(No.61773114)the Key Research and Development Plan(Industry Foresight and Common Key Technology)of Jiangsu Province(No.BE2017007-3)
文摘A novel framework is proposed to obtain physiologically meaningful features for Alzheimer's disease(AD)classification based on sparse functional connectivity and non-negative matrix factorization.Specifically,the non-negative adaptive sparse representation(NASR)method is applied to compute the sparse functional connectivity among brain regions based on functional magnetic resonance imaging(fMRI)data for feature extraction.Afterwards,the sparse non-negative matrix factorization(sNMF)method is adopted for dimensionality reduction to obtain low-dimensional features with straightforward physical meaning.The experimental results show that the proposed framework outperforms the competing frameworks in terms of classification accuracy,sensitivity and specificity.Furthermore,three sub-networks,including the default mode network,the basal ganglia-thalamus-limbic network and the temporal-insular network,are found to have notable differences between the AD patients and the healthy subjects.The proposed framework can effectively identify AD patients and has potentials for extending the understanding of the pathological changes of AD.
文摘The paper intfoduces a PC-DSP based real-time digital simulator which is portable in size and aimed at the closed-loop testing of various types of protective relays for their design and application. The simulator can be widely used in not only concerning utilities but also manufacturers and research / certification institutes because of its many functions. The hardware architecture and software implementation of the simulator are described. The main features and functions of the simulator are also
文摘A series of novel uracil and 5-fluorouracil-l-yl-acetic acid-colchicine derivatives（6a--6n） was synthe- sized via coupling and 5-fluorouracil（5-FU） with C-10 analogues of colchicine. The antitumor activities of the target compounds against human hepatocellular earcinoma（BEL7402） cells, human ovary carcinoma（A2780） cells, human lung adenocarcinoma（A549） cells and human breast carcinoma（MCF7） cells were tested in vitro, and the structure-activity relationship（SAR） of the compounds was also studied. The bioassay results demonstrate that most of the tested compounds display significant activity and particularly, compounds 6a, 6e, 6h and 61 show more potent cytotoxic activities than 5-fluorouracil and colchicine. The results show that the new derivatives of colchicine are potential suppressors on human cancer.
