In the phase of field evaluation, the changing of interwell reservoir may be out of control if the geological model was built only on well data due to few existing wells. The uncertainty of the interwell reservoir int...In the phase of field evaluation, the changing of interwell reservoir may be out of control if the geological model was built only on well data due to few existing wells. The uncertainty of the interwell reservoir interpolation based only on well data can be decreased by comprehensive utilization of geological, logging and seismic data, especially by using highly relative seismic properties from 3D seismic data adjusted by well point data to restrict interpolation of geological properties. A 3D-geological model which takes the sand body as the direct modeling object was built through stacking the structure, reservoir and water/oil/gas properties together in 3D space.展开更多
The generation mechanisms of supercontinuum(SC)and the effect of the modified Raman model on SC are further analyzed in a flat dispersion photonic crystal fiber(PCF)with two-zero dispersion wavelengths(TZDWs)by introd...The generation mechanisms of supercontinuum(SC)and the effect of the modified Raman model on SC are further analyzed in a flat dispersion photonic crystal fiber(PCF)with two-zero dispersion wavelengths(TZDWs)by introducing an accurate Raman response function in the scalar nonlinear Scho?dinger equation.The results show that the introduction of Boson peak in the modified Raman gain model not only results in much rapider broadening of SC but also promotes more pump pulse energy transferred to the short wavelength region,which is related to stimulated Raman scattering.Moreover,SC generated from the PCF splits into two spectral bands,and their spectral peaks rapidly separate and broaden with the increase of incidcnt power.Double-band central wavelengths are finally located at about 850 nm and 1220 nm.The pumping energy depletion phenomenon occurs.The simulated results from the modified Raman model are in better agreement with the experimental results than that from the single-Lorentzian moder.展开更多
A high-average-power diode-pumped narrowband regenerative chirped pulse amplifier is developed using the thin-rod Nd:YAG laser architecture for optical parametric chirped-pulse amplification(OPCPA).The effect of the e...A high-average-power diode-pumped narrowband regenerative chirped pulse amplifier is developed using the thin-rod Nd:YAG laser architecture for optical parametric chirped-pulse amplification(OPCPA).The effect of the etalons on the amplified pulse in the regenerative cavity is studied experimentally and theoretically.By inserting glass etalons of thickness 1 mm and 5 mm into the regenerative cavity,the pre-stretching pulse from anÖffner stretcher is further broadened to above 200 ps,which matches the amplification windows of the signal pulses in OPCPA and is suitable for use as a pump source in the OPCPA system.The bandwidth of the amplified pulse is 1.5 nm,and an output energy of 2 mJ is achieved at a repetition rate of 10 Hz.展开更多
The first-generation taxanes(including paclitaxel and docetaxel)are widely used for the treatment of various cancers in clinical settings.In the past decade,a series of new-generation taxanes have been developed which...The first-generation taxanes(including paclitaxel and docetaxel)are widely used for the treatment of various cancers in clinical settings.In the past decade,a series of new-generation taxanes have been developed which are effective in the inhibition of tumor resistance.However,intravenous(i.v.)infusion is still the only route of administration,and may result in serious adverse reactions with respect to the utilization of Cremophor EL or Tween-80 as solvent.Besides,the dosing schedule is also limited.Therefore,oral administration of taxanes is urgently needed to avoid the adverse reactionss and increase dosing frequency.In this review,we first outlined the discovery and development of taxane-based anticancer agents.Furthermore,we summarized the research progress on the oral formulations of taxanes and proposed some thoughts on the future development of oral taxane formulations.展开更多
文摘In the phase of field evaluation, the changing of interwell reservoir may be out of control if the geological model was built only on well data due to few existing wells. The uncertainty of the interwell reservoir interpolation based only on well data can be decreased by comprehensive utilization of geological, logging and seismic data, especially by using highly relative seismic properties from 3D seismic data adjusted by well point data to restrict interpolation of geological properties. A 3D-geological model which takes the sand body as the direct modeling object was built through stacking the structure, reservoir and water/oil/gas properties together in 3D space.
基金Supported by the National Basic Research Program of China under Grant No 2006CB806001the Knowledge Innovation Project of Chinese Academy of Sciences under Grant No KGCX-YW-417-2Shanghai Commission of Science and Technology under Grant No 07JC14055.
文摘The generation mechanisms of supercontinuum(SC)and the effect of the modified Raman model on SC are further analyzed in a flat dispersion photonic crystal fiber(PCF)with two-zero dispersion wavelengths(TZDWs)by introducing an accurate Raman response function in the scalar nonlinear Scho?dinger equation.The results show that the introduction of Boson peak in the modified Raman gain model not only results in much rapider broadening of SC but also promotes more pump pulse energy transferred to the short wavelength region,which is related to stimulated Raman scattering.Moreover,SC generated from the PCF splits into two spectral bands,and their spectral peaks rapidly separate and broaden with the increase of incidcnt power.Double-band central wavelengths are finally located at about 850 nm and 1220 nm.The pumping energy depletion phenomenon occurs.The simulated results from the modified Raman model are in better agreement with the experimental results than that from the single-Lorentzian moder.
基金Supported by the National Basic Research Program of China under Grant Nos.2006CB806001 and 2011CB808101the National Natural Science Foundation of China under Grant Nos.10734080,60908008 and 60921004+1 种基金the Fund of the State Key Laboratory of High Field Laser Physics and Shanghai Commission of Science and Technology under Grant Nos.07JC14055 and 09QA1406500the Scientific Research Foundation of Zhejiang University of Technology under Grant Nos.109004129 and 2011XY026.
文摘A high-average-power diode-pumped narrowband regenerative chirped pulse amplifier is developed using the thin-rod Nd:YAG laser architecture for optical parametric chirped-pulse amplification(OPCPA).The effect of the etalons on the amplified pulse in the regenerative cavity is studied experimentally and theoretically.By inserting glass etalons of thickness 1 mm and 5 mm into the regenerative cavity,the pre-stretching pulse from anÖffner stretcher is further broadened to above 200 ps,which matches the amplification windows of the signal pulses in OPCPA and is suitable for use as a pump source in the OPCPA system.The bandwidth of the amplified pulse is 1.5 nm,and an output energy of 2 mJ is achieved at a repetition rate of 10 Hz.
文摘The first-generation taxanes(including paclitaxel and docetaxel)are widely used for the treatment of various cancers in clinical settings.In the past decade,a series of new-generation taxanes have been developed which are effective in the inhibition of tumor resistance.However,intravenous(i.v.)infusion is still the only route of administration,and may result in serious adverse reactions with respect to the utilization of Cremophor EL or Tween-80 as solvent.Besides,the dosing schedule is also limited.Therefore,oral administration of taxanes is urgently needed to avoid the adverse reactionss and increase dosing frequency.In this review,we first outlined the discovery and development of taxane-based anticancer agents.Furthermore,we summarized the research progress on the oral formulations of taxanes and proposed some thoughts on the future development of oral taxane formulations.
