Fluorescence imaging analysis of microscale dynamic process(e.g.,metabolism,mitosis,endocytosis,exocytosis,etc.)is of particular significance to study the related pathogenesis and design the intracellular drug deliver...Fluorescence imaging analysis of microscale dynamic process(e.g.,metabolism,mitosis,endocytosis,exocytosis,etc.)is of particular significance to study the related pathogenesis and design the intracellular drug delivery systems.Owing to unique physical,chemical and/or biological properties,silicon(Si)-based nanomaterials have been employed to design and construct different types of nanoprobes for the imaging analysis of diseases.Thus,we herein present an overview of recent advances in fluorescent silicon nanomaterials imaging technology for analyzing and diagnosing diseases.Firstly,we mainly introduce the construction of Si nanomaterials-based bioprobes for long-term fluorescence imaging analysis of cancer-related biological information,such as tumour cells,biomarkers and nanocarriers.Afterwards,we focus on the Si nanomaterials-based imaging technology for monitoring the dynamic process of pathological changes of various ocular diseases(e.g.,ocular angiogenesis,bacterial keratitis,etc.).Then,we outline the construction of Si-based nanoprobes and their applications in simultaneously imaging and treating the bacteria-induced diseases caused by broad-spectrum bacteria-related pathogens.Finally,we further discuss the major challenges and prospects for developing silicon-based fluorescence imaging technology.展开更多
The most basic function of slope vegetation is to strengthen rock and soil mass through plant roots which increase the shear strength of the slope markedly and thereby increase the stability of the slope. However, the...The most basic function of slope vegetation is to strengthen rock and soil mass through plant roots which increase the shear strength of the slope markedly and thereby increase the stability of the slope. However, the calculation of the reinforcement ability of slope vegetation still remains at the stage of judging by experience, because it is rather difficult due to the intricacy and volatility of the force condition of plant roots in rock and soil medium. Although some scholars have tried to study the interaction between plant roots and soil mass, the systemic analysis of the mechanical reinforcement mechanism and the contribution of plant roots to strengthening the rock and soil mass on the surface of the slope is untapped. In this paper, by analyzing the mechanism of slope vegetation and the corresponding reinforcement effect, the effects that slope vegetation generates on the shear strength of slope soil mass are studied, thereby a theoretical basis for plant protection designing is provided.展开更多
基金This work was supported by the National Natural Science Foundation of China(Nos.21825402,22074101)the Natural Science Foundation of Jiangsu Province of China(No.BK20191417)+3 种基金the Program for Jiangsu(China)Specially-Appointed Professors to Prof.HE Yaothe Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),Chinathe 111 Project of Chinathe Fund of the Collaborative Innovation Center of Suzhou Nano Science and Technology,China(NANO-CIC).
文摘Fluorescence imaging analysis of microscale dynamic process(e.g.,metabolism,mitosis,endocytosis,exocytosis,etc.)is of particular significance to study the related pathogenesis and design the intracellular drug delivery systems.Owing to unique physical,chemical and/or biological properties,silicon(Si)-based nanomaterials have been employed to design and construct different types of nanoprobes for the imaging analysis of diseases.Thus,we herein present an overview of recent advances in fluorescent silicon nanomaterials imaging technology for analyzing and diagnosing diseases.Firstly,we mainly introduce the construction of Si nanomaterials-based bioprobes for long-term fluorescence imaging analysis of cancer-related biological information,such as tumour cells,biomarkers and nanocarriers.Afterwards,we focus on the Si nanomaterials-based imaging technology for monitoring the dynamic process of pathological changes of various ocular diseases(e.g.,ocular angiogenesis,bacterial keratitis,etc.).Then,we outline the construction of Si-based nanoprobes and their applications in simultaneously imaging and treating the bacteria-induced diseases caused by broad-spectrum bacteria-related pathogens.Finally,we further discuss the major challenges and prospects for developing silicon-based fluorescence imaging technology.
基金supported by Research Fund for the Doctoral Program of Higher Education (Grant No 20090211110016)Gansu Provincial Natu-ral Science Foundation of China (Grant No 096RJZA048)Science & Technology Project supported by Yunnan Provincial Communication Department
文摘The most basic function of slope vegetation is to strengthen rock and soil mass through plant roots which increase the shear strength of the slope markedly and thereby increase the stability of the slope. However, the calculation of the reinforcement ability of slope vegetation still remains at the stage of judging by experience, because it is rather difficult due to the intricacy and volatility of the force condition of plant roots in rock and soil medium. Although some scholars have tried to study the interaction between plant roots and soil mass, the systemic analysis of the mechanical reinforcement mechanism and the contribution of plant roots to strengthening the rock and soil mass on the surface of the slope is untapped. In this paper, by analyzing the mechanism of slope vegetation and the corresponding reinforcement effect, the effects that slope vegetation generates on the shear strength of slope soil mass are studied, thereby a theoretical basis for plant protection designing is provided.
