针对时域非平稳振动信号模式混叠、信噪比低,以及传统稀疏表示算法模型复杂、优化求解算法难以确定,导致故障特征提取难的问题,提出了频域组稀疏和群桥约束改进迭代收缩阈值优化的故障特征提取方法(Group Sparse Representation in Freq...针对时域非平稳振动信号模式混叠、信噪比低,以及传统稀疏表示算法模型复杂、优化求解算法难以确定,导致故障特征提取难的问题,提出了频域组稀疏和群桥约束改进迭代收缩阈值优化的故障特征提取方法(Group Sparse Representation in Frequency Domain,GSRF)。将振动信号转换至频域并对变量分组,构造施加群桥约束的最小二乘回归模型,准确筛选冲击相关变量;引入迭代重加权系数简化方程,以软阈值收缩优化求解频域稀疏信号;对重构的时域稀疏信号进行包络频谱分析提取故障特征。试验结果表明,提出的频域组稀疏算法优于传统的结合L21范数约束的组稀疏索套方法,可有效提取微弱故障特征,实现稀疏域下的轴承故障诊断。展开更多
[目的]比较经皮修复与开放修复治疗急性闭合性跟腱断裂的临床效果。[方法]回顾性研究2015年7月—2020年2月于本院手术治疗的急性闭合性跟腱断裂72例患者的临床资料。根据医患沟通结果,38例改良Ma-Griffith经皮修复(微创组),另外34例采...[目的]比较经皮修复与开放修复治疗急性闭合性跟腱断裂的临床效果。[方法]回顾性研究2015年7月—2020年2月于本院手术治疗的急性闭合性跟腱断裂72例患者的临床资料。根据医患沟通结果,38例改良Ma-Griffith经皮修复(微创组),另外34例采用传统开放修复(开放组)。比较两组围手术期和随访资料。[结果]微创组手术时间[(45.5±5.9) min vs (49.0±7.0) min, P<0.05]、切口总长度[(5.5±0.8) cm vs (7.9±0.9) cm, P<0.05]、术中失血量[(16.1±4.1) ml vs (25.9±4.9) ml, P<0.05]、下地行走时间[(4.0±1.6) d vs (7.0±1.7) d, P<0.05]、切口愈合等级[甲/乙/丙, 38/0/0 vs 30/4/0, P<0.05]、住院时间[(8.2±1.9) d vs (12.0±2.5) d, P<0.05]均显著优于开放组。微创组腓肠神经损伤发生率显著高于开放组(20.1%vs 2.9%, P<0.05),但微创组术后切口感染发生率显著低于开放组(0.0%vs 11.8%, P<0.05)。所有患者平均随访(15.9±2.8)个月,微创组术后完全负重活动时间显著早于开放组[(59.3±4.7) d vs (87.8±4.4) d, P<0.05]。随术后时间推移,两组VAS评分显著减小(P<0.05),而AOFAS评分及踝关节活动度显著增加(P<0.05)。在术后1个月,微创组的VAS [(1.9±0.6) vs (3.9±0.8), P<0.05]、AOFAS [(86.0±3.4) vs (74.7±5.0),P<0.05]、ATRS评分[(89.2±4.0) vs (77.2±4.0), P<0.05]及踝关节活动度[(48.7±3.6)°vs (39.7±4.1)°, P<0.05]均显著优于开放组(P<0.05),但是,末次随访时两组间上述指标的差异均无统计学意义(P>0.05)。[结论]经皮修复术作为一种微创手术,虽然腓肠神经损伤的风险较高,但与开放修复术相比,能明显降低跟腱断裂后的感染率,促进术后早期功能恢复。展开更多
目的探讨直接前入路和后入路全髋关节置换术(total hip arthropiasty,THA)对髋关节功能恢复的效果。方法选取我院2017年12月至2019年3月收治的300例行THA患者,按照入路方式分为对照组(后入路行THA)、观察组(直接前入路行THA)各150例。...目的探讨直接前入路和后入路全髋关节置换术(total hip arthropiasty,THA)对髋关节功能恢复的效果。方法选取我院2017年12月至2019年3月收治的300例行THA患者,按照入路方式分为对照组(后入路行THA)、观察组(直接前入路行THA)各150例。对照组年龄53~79岁,体质指数18.50~28.01 kg/m^2,美国麻醉医师协会(American society of anesthesiologists,ASA)评分1~3分。观察组年龄54~78岁,体质指数18.81~28.04 kg/m^2,ASA评分1~3分。两组一般资料比较差异无统计学意义(P>0.05),不具有可比性。对比两组手术时间、术中出血量、切口长度、术后住院时间、术后疼痛视觉模拟(vissr atmospheric sounder,VAS)评分,骨生成指标:骨钙素(osteocalcin,OC)、I型前胶原氨基末端前肽(procollagen type I n-terminalpropetide,PINP)、骨碱性磷酸酶(bone alkaline phosphatase,BALP)、血清炎症因子白介素(interleukin,IL)-1β、IL-6、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α),Harris髋关节功能评分,牛津髋关节评分标准(oxford hip score,OHS),术后并发症发生率。结果两组手术时间、出血量、切口长度、臼杯外展角、臼杯前倾角相比差异无统计学意义(P>0.05);观察组住院时间短于对照组(P=0.000);观察组术后6 h、术后12 h、术后24 h VAS评分均低于对照组(P<0.05);两组骨生成标志物OC、P1NP、BALP水平相比,差异无统计学意义(P>0.05);术后观察组血清IL-1β、IL-6、TNF-α水平均低于对照组,两组相比差异均有统计学意义(P<0.05),两组术后并发症发生率相比,差异无统计学意义(P>0.05);术后1、3个月,观察组的髋关节功能评分均高于对照组(P=0.000);观察组术后1、3个月的OHS评分低于对照组,差异有统计学意义(P=0.000),10 m步行测试高于对照组(P=0.000)。结论直接前入路行THA应激小,能够缩短住院时间,且不会对骨代谢产生明显的影响,有利于髋关节功能早期恢复。展开更多
Background There are no data on more tolerable capecitabine doses in elderly patients in Chinese population. The aim of this study was to evaluate the activity and safety of capecitabine combined with weekly docetaxel...Background There are no data on more tolerable capecitabine doses in elderly patients in Chinese population. The aim of this study was to evaluate the activity and safety of capecitabine combined with weekly docetaxel for the treatment of anthracycline-resistant metastatic breast cancer (MBC) in older Chinese patients. Methods MBC patients aged 〉65 years pretreated with 1-5 prior chemotherapy regimens, including an anthracycline, received oral capecitabine 825 mg/m^2 twice daily, days 1-14, plus docetaxel 30 mg/m^2 on days 1 and 8 every 21 days. All 41 enrolled patients received at least 1 dose of treatment and were evaluable for safety; 38 received at least 2 cycles (median 4, range 2-8) and were evaluable for efficacy. Results The overall objective response rate was 47%, including complete responses in 8% of patients. Median time to progression was 8.9 months. Median overall survival was 17.6 months. The most common side effects were haematological and gastrointestinal toxicities and hand-foot syndrome. The only grade 3/4 adverse events were neutropenia (12%), alopecia (7%), grade 3 nausea and vomiting (2%) and grade 3 nail toxicity (2%). Conclusions Capecitabine 825 mg/m^2 twice daily plus weekly docetaxel is active with an acceptable safety profile in Chinese women 〉65 years with anthracycline-resistant MBC. Efficacy and tolerability compare favourably with previously reported trials evaluating higher capecitabine doses in combination with 3-weekly or weekly docetaxel.展开更多
文摘针对时域非平稳振动信号模式混叠、信噪比低,以及传统稀疏表示算法模型复杂、优化求解算法难以确定,导致故障特征提取难的问题,提出了频域组稀疏和群桥约束改进迭代收缩阈值优化的故障特征提取方法(Group Sparse Representation in Frequency Domain,GSRF)。将振动信号转换至频域并对变量分组,构造施加群桥约束的最小二乘回归模型,准确筛选冲击相关变量;引入迭代重加权系数简化方程,以软阈值收缩优化求解频域稀疏信号;对重构的时域稀疏信号进行包络频谱分析提取故障特征。试验结果表明,提出的频域组稀疏算法优于传统的结合L21范数约束的组稀疏索套方法,可有效提取微弱故障特征,实现稀疏域下的轴承故障诊断。
文摘[目的]比较经皮修复与开放修复治疗急性闭合性跟腱断裂的临床效果。[方法]回顾性研究2015年7月—2020年2月于本院手术治疗的急性闭合性跟腱断裂72例患者的临床资料。根据医患沟通结果,38例改良Ma-Griffith经皮修复(微创组),另外34例采用传统开放修复(开放组)。比较两组围手术期和随访资料。[结果]微创组手术时间[(45.5±5.9) min vs (49.0±7.0) min, P<0.05]、切口总长度[(5.5±0.8) cm vs (7.9±0.9) cm, P<0.05]、术中失血量[(16.1±4.1) ml vs (25.9±4.9) ml, P<0.05]、下地行走时间[(4.0±1.6) d vs (7.0±1.7) d, P<0.05]、切口愈合等级[甲/乙/丙, 38/0/0 vs 30/4/0, P<0.05]、住院时间[(8.2±1.9) d vs (12.0±2.5) d, P<0.05]均显著优于开放组。微创组腓肠神经损伤发生率显著高于开放组(20.1%vs 2.9%, P<0.05),但微创组术后切口感染发生率显著低于开放组(0.0%vs 11.8%, P<0.05)。所有患者平均随访(15.9±2.8)个月,微创组术后完全负重活动时间显著早于开放组[(59.3±4.7) d vs (87.8±4.4) d, P<0.05]。随术后时间推移,两组VAS评分显著减小(P<0.05),而AOFAS评分及踝关节活动度显著增加(P<0.05)。在术后1个月,微创组的VAS [(1.9±0.6) vs (3.9±0.8), P<0.05]、AOFAS [(86.0±3.4) vs (74.7±5.0),P<0.05]、ATRS评分[(89.2±4.0) vs (77.2±4.0), P<0.05]及踝关节活动度[(48.7±3.6)°vs (39.7±4.1)°, P<0.05]均显著优于开放组(P<0.05),但是,末次随访时两组间上述指标的差异均无统计学意义(P>0.05)。[结论]经皮修复术作为一种微创手术,虽然腓肠神经损伤的风险较高,但与开放修复术相比,能明显降低跟腱断裂后的感染率,促进术后早期功能恢复。
文摘目的探讨直接前入路和后入路全髋关节置换术(total hip arthropiasty,THA)对髋关节功能恢复的效果。方法选取我院2017年12月至2019年3月收治的300例行THA患者,按照入路方式分为对照组(后入路行THA)、观察组(直接前入路行THA)各150例。对照组年龄53~79岁,体质指数18.50~28.01 kg/m^2,美国麻醉医师协会(American society of anesthesiologists,ASA)评分1~3分。观察组年龄54~78岁,体质指数18.81~28.04 kg/m^2,ASA评分1~3分。两组一般资料比较差异无统计学意义(P>0.05),不具有可比性。对比两组手术时间、术中出血量、切口长度、术后住院时间、术后疼痛视觉模拟(vissr atmospheric sounder,VAS)评分,骨生成指标:骨钙素(osteocalcin,OC)、I型前胶原氨基末端前肽(procollagen type I n-terminalpropetide,PINP)、骨碱性磷酸酶(bone alkaline phosphatase,BALP)、血清炎症因子白介素(interleukin,IL)-1β、IL-6、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α),Harris髋关节功能评分,牛津髋关节评分标准(oxford hip score,OHS),术后并发症发生率。结果两组手术时间、出血量、切口长度、臼杯外展角、臼杯前倾角相比差异无统计学意义(P>0.05);观察组住院时间短于对照组(P=0.000);观察组术后6 h、术后12 h、术后24 h VAS评分均低于对照组(P<0.05);两组骨生成标志物OC、P1NP、BALP水平相比,差异无统计学意义(P>0.05);术后观察组血清IL-1β、IL-6、TNF-α水平均低于对照组,两组相比差异均有统计学意义(P<0.05),两组术后并发症发生率相比,差异无统计学意义(P>0.05);术后1、3个月,观察组的髋关节功能评分均高于对照组(P=0.000);观察组术后1、3个月的OHS评分低于对照组,差异有统计学意义(P=0.000),10 m步行测试高于对照组(P=0.000)。结论直接前入路行THA应激小,能够缩短住院时间,且不会对骨代谢产生明显的影响,有利于髋关节功能早期恢复。
文摘Background There are no data on more tolerable capecitabine doses in elderly patients in Chinese population. The aim of this study was to evaluate the activity and safety of capecitabine combined with weekly docetaxel for the treatment of anthracycline-resistant metastatic breast cancer (MBC) in older Chinese patients. Methods MBC patients aged 〉65 years pretreated with 1-5 prior chemotherapy regimens, including an anthracycline, received oral capecitabine 825 mg/m^2 twice daily, days 1-14, plus docetaxel 30 mg/m^2 on days 1 and 8 every 21 days. All 41 enrolled patients received at least 1 dose of treatment and were evaluable for safety; 38 received at least 2 cycles (median 4, range 2-8) and were evaluable for efficacy. Results The overall objective response rate was 47%, including complete responses in 8% of patients. Median time to progression was 8.9 months. Median overall survival was 17.6 months. The most common side effects were haematological and gastrointestinal toxicities and hand-foot syndrome. The only grade 3/4 adverse events were neutropenia (12%), alopecia (7%), grade 3 nausea and vomiting (2%) and grade 3 nail toxicity (2%). Conclusions Capecitabine 825 mg/m^2 twice daily plus weekly docetaxel is active with an acceptable safety profile in Chinese women 〉65 years with anthracycline-resistant MBC. Efficacy and tolerability compare favourably with previously reported trials evaluating higher capecitabine doses in combination with 3-weekly or weekly docetaxel.