分布式低碳能源站(distributed low-carbon energy station,DLCES)能提高能源利用效率和可再生能源消纳率,准确预测DLCES的未来运行状态能保障其安全可靠运行。为此,提出一种基于数据驱动的分布式低碳能源站状态预测方法。首先,分析DLCE...分布式低碳能源站(distributed low-carbon energy station,DLCES)能提高能源利用效率和可再生能源消纳率,准确预测DLCES的未来运行状态能保障其安全可靠运行。为此,提出一种基于数据驱动的分布式低碳能源站状态预测方法。首先,分析DLCES结构与运行状态,利用关键状态量和偏移量变化将运行状态划分为正常、恢复、临界及紧急状态;其次,构建深度长短期记忆(long-short term memory,LSTM)模型,并利用改进粒子群算法进行超参数优化,提升预测模型性能;最后,利用测试集数据对柯西变异的粒子群算法(Cauchy mutation particle swarm optimization,CMPSO)和LSTM相结合的模型进行预测仿真,将其与RNN、LSTM及BP神经网络预测结果对比分析。结果表明:CMPSO-LSTM模型能提高预测效果,更具实际意义。展开更多
Chemical epigenetic manipulation was applied to the zoanthid-derived fungus Cochliobolus lunatus(TA26-46)with a histone deacetylation modifier(100μmol L^(−1) nicotinamide),resulting in the isolation of a new 14-membe...Chemical epigenetic manipulation was applied to the zoanthid-derived fungus Cochliobolus lunatus(TA26-46)with a histone deacetylation modifier(100μmol L^(−1) nicotinamide),resulting in the isolation of a new 14-membered resorcylic acid lactone named 7′(Z)-zeaenol(1),together with six known analogues(2−7)from the treated broth.The planar structure of 1 was determined by comprehensive NMR spectroscopy and HRESIMS data.The absolute configuration of 1 was elucidated by ECD spectrum,^(13)C NMR shift calculations,and on the basis of biogenetic considerations.Compound 5 exhibited cytotoxic activity against the human tumor cell lines A549,HCT-116,HT-29,Hela,MCF-7,and K562 with the IC_(50) values ranging from 2.54 to 7.44μmolL^(−1).展开更多
文摘分布式低碳能源站(distributed low-carbon energy station,DLCES)能提高能源利用效率和可再生能源消纳率,准确预测DLCES的未来运行状态能保障其安全可靠运行。为此,提出一种基于数据驱动的分布式低碳能源站状态预测方法。首先,分析DLCES结构与运行状态,利用关键状态量和偏移量变化将运行状态划分为正常、恢复、临界及紧急状态;其次,构建深度长短期记忆(long-short term memory,LSTM)模型,并利用改进粒子群算法进行超参数优化,提升预测模型性能;最后,利用测试集数据对柯西变异的粒子群算法(Cauchy mutation particle swarm optimization,CMPSO)和LSTM相结合的模型进行预测仿真,将其与RNN、LSTM及BP神经网络预测结果对比分析。结果表明:CMPSO-LSTM模型能提高预测效果,更具实际意义。
基金supported by the National Natural Science Foundation of China(Nos.81673350,81703411,41776156)the National Science and Technology Major Project for Significant New Drugs Development,China(No.2018ZX09735-004)+1 种基金the Fundamental Research Funds for the Central Universities of China(No.201962002)the Taishan Scholars Program,China.
文摘Chemical epigenetic manipulation was applied to the zoanthid-derived fungus Cochliobolus lunatus(TA26-46)with a histone deacetylation modifier(100μmol L^(−1) nicotinamide),resulting in the isolation of a new 14-membered resorcylic acid lactone named 7′(Z)-zeaenol(1),together with six known analogues(2−7)from the treated broth.The planar structure of 1 was determined by comprehensive NMR spectroscopy and HRESIMS data.The absolute configuration of 1 was elucidated by ECD spectrum,^(13)C NMR shift calculations,and on the basis of biogenetic considerations.Compound 5 exhibited cytotoxic activity against the human tumor cell lines A549,HCT-116,HT-29,Hela,MCF-7,and K562 with the IC_(50) values ranging from 2.54 to 7.44μmolL^(−1).
