目的探讨孕早期年龄、身体质量指数(body mass index,BMI)和妊娠相关血浆蛋白A(pregnancy-associated plasma protein A,PAPPA)综合评价对妊娠糖尿病(gestational diabetes mellitus,GDM)的预测价值。方法选取365例孕妇作为研究对象,其...目的探讨孕早期年龄、身体质量指数(body mass index,BMI)和妊娠相关血浆蛋白A(pregnancy-associated plasma protein A,PAPPA)综合评价对妊娠糖尿病(gestational diabetes mellitus,GDM)的预测价值。方法选取365例孕妇作为研究对象,其中GDM孕妇112例,非GDM孕妇253例;收集孕妇孕期检查资料,分析孕妇孕早期BMI,年龄和PAPPA值等与GDM的相关性。结果GDM组年龄、BMI,空腹血糖(gestational diabetes mellitus,FPG),餐后1h血糖(1hPG)和餐后2h血糖(2hPG)均高于对照组,差异具有统计学意义(t=-21.836^-0.459,均P=0.000);PAPPA与2hPG有显著相关性(r=-0.242,P=0.010);PAPPA,BMI及年龄与GDM有显著相关性(wald=7.011,7.174,20.476,均P=0.000);PAPPA单项所得ROC曲线与联合(PAPPA+BMI+年龄)所得比较,差异无统计学意义(z=1.667,P=0.095)。PAPPA,BMI+年龄及PAPPA+BMI+年龄的敏感度、特异度和诊断准确度均<0.7,诊断比值比均<1。结论PAPPA,BMI和年龄对GMD有一定的预测价值,但有限。展开更多
Background Hemorrhagic fever with renal syndrome (HFRS) is endemic in Junan county, Shandong Province, China. We conducted geographic information system (GIS)-based spatial analysis with the objective of estimatin...Background Hemorrhagic fever with renal syndrome (HFRS) is endemic in Junan county, Shandong Province, China. We conducted geographic information system (GIS)-based spatial analysis with the objective of estimating the spatial distribution of rodent populations and their hantavirus infection patterns, to describe the spatial relationships of hantavirus strains in small ecological areas and to identify key areas in endemic areas of HFRS for future public health planning and resource allocation.展开更多
文摘目的探讨孕早期年龄、身体质量指数(body mass index,BMI)和妊娠相关血浆蛋白A(pregnancy-associated plasma protein A,PAPPA)综合评价对妊娠糖尿病(gestational diabetes mellitus,GDM)的预测价值。方法选取365例孕妇作为研究对象,其中GDM孕妇112例,非GDM孕妇253例;收集孕妇孕期检查资料,分析孕妇孕早期BMI,年龄和PAPPA值等与GDM的相关性。结果GDM组年龄、BMI,空腹血糖(gestational diabetes mellitus,FPG),餐后1h血糖(1hPG)和餐后2h血糖(2hPG)均高于对照组,差异具有统计学意义(t=-21.836^-0.459,均P=0.000);PAPPA与2hPG有显著相关性(r=-0.242,P=0.010);PAPPA,BMI及年龄与GDM有显著相关性(wald=7.011,7.174,20.476,均P=0.000);PAPPA单项所得ROC曲线与联合(PAPPA+BMI+年龄)所得比较,差异无统计学意义(z=1.667,P=0.095)。PAPPA,BMI+年龄及PAPPA+BMI+年龄的敏感度、特异度和诊断准确度均<0.7,诊断比值比均<1。结论PAPPA,BMI和年龄对GMD有一定的预测价值,但有限。
基金This study was supported by a grant from the National Natural Science Foundation of China (No. 30471489).
文摘Background Hemorrhagic fever with renal syndrome (HFRS) is endemic in Junan county, Shandong Province, China. We conducted geographic information system (GIS)-based spatial analysis with the objective of estimating the spatial distribution of rodent populations and their hantavirus infection patterns, to describe the spatial relationships of hantavirus strains in small ecological areas and to identify key areas in endemic areas of HFRS for future public health planning and resource allocation.