目的:探讨改良中医情绪疗法联合帕罗西汀在抑郁症患者中的疗效观察及对外周血T淋巴细胞亚群的影响。方法:选择2014年5月~2017年4月以抑郁症收治的90例患者作为对象,按照随机数字表法分为对照组( n =45)和观察组( n =45)。对照组采用帕...目的:探讨改良中医情绪疗法联合帕罗西汀在抑郁症患者中的疗效观察及对外周血T淋巴细胞亚群的影响。方法:选择2014年5月~2017年4月以抑郁症收治的90例患者作为对象,按照随机数字表法分为对照组( n =45)和观察组( n =45)。对照组采用帕罗西汀治疗,观察组在对照组基础上联合改良中医情绪疗法治疗,两组均进行1个月治疗,治疗完毕后对患者效果进行评估。采用汉密尔顿抑郁量表(HAMD)对两组患者治疗前、治疗后1个月从认知障碍、睡眠障碍、躯体性焦虑、精神性焦虑及情绪进行评估;采用酶联免疫吸附实验测定两组患者治疗前、治疗后1个月白细胞介素-2(IL-2)和肿瘤坏死因子-α(TNF-α)水平;采用流式细胞仪测定两组患者治疗前、治疗后1个月CD3 ^+、CD4 ^+、CD8 ^+及CD4 +/CD8 ^+T细胞水平;记录并统计两组治疗后恶心、口干、便秘及头晕发生率,比较两组临床疗效及目标治疗对外周血T淋巴细胞水平的影响。结果:观察组治疗后1个月认知障碍、睡眠障碍、躯体性焦虑、精神性焦虑及情绪评分均低于对照组( P <0.05);IL-2及TNF-α水平均低于对照组( P <0.05);CD3 ^+、CD4 ^+、CD4 ^+/CD8 ^+T细胞水平均高于对照组( P <0.05);CD8 ^+T细胞水平低于对照组( P <0.05)。观察组与对照组治疗后比较,恶心、口干、便秘及头晕发生率差异无统计学意义( P >0.05)。结论:将改良中医情绪疗法联合帕罗西汀用于抑郁症患者中有助于改善患者抑郁症状,降低炎症因子水平,能提高T淋巴细胞水平,值得推广。展开更多
As one of the secondary metabolites,the isoflavones formed during the development of soybean[Glycine max(L.)Merr.]seeds.The total and individual isoflavone contents,a typical quantitative trait,were affected by signif...As one of the secondary metabolites,the isoflavones formed during the development of soybean[Glycine max(L.)Merr.]seeds.The total and individual isoflavone contents,a typical quantitative trait,were affected by significant genotypes of environments(GE)interaction and controlled by many genes with main or minor effects.In the present study,99 soybean cultivars,collected from northeastern China,were used to analyze the isoflavone performances.Genotype-genotype×environment(GGE)biplot software demonstrated an ability to provide information on genetic main effects than solely on phenotypic perform.Highperformance liquid chromatography(HPLC)system was used to extract and determine the isoflavone contents.The results indicated that most genotypes significantly varied among six tested environments.P40(Xiaolimoshidou)was the best-performed genotype with mean performance and stability for glycitein content across six different environments.P88(L-59Peking)was the super genotype with mean performance and stability on each tested environment for daidzein,genistein and the total isoflavone.E5(Gongzhuling in 2016)was the best environment for optimal environmental factor mining.P70(Charleston),P67(Baichengmoshidou)and P50(Jiunong 20)were the optimal genotypes with the highest field among 99 cultivars on each tested environment for genistein.P70(Charleston),P67(Baichengmoshidou)and P14(Hefeng 25)were the optimal genotypes with the highest field among 99 cultivars on each tested environment for daidzein.P40(Xiaolimoshidou),P45(Jinshanchamodou),P33(Dongnong 48)and P56(L-5)were the optimal genotypes with the highest field among 99 cultivars on each tested environment for glycitein.P70(Charleston)and P67(Baichengmoshidou)were the optimal genotypes with the highest field among 99 cultivars on each tested environment for the total isoflavone.GGE biplot was a rational method for stability and adaptation evaluation of soybean isoflavones,and could assist soybean breeder to select a good culture and a suitable tested site.It provided a scientific basis for the establishment of a breeding site and a selection site of soybean isoflavones.This study was valuable to identify genotypes with stable performances of isoflavones of these 99 cultivars for developing new cultivars.展开更多
Background Midgastric transverse band （MTB） was first observed over 100 years ago, after that many researchers worked on the subject postulated its physiologic role and the role in gastrointestinal diseases, but its...Background Midgastric transverse band （MTB） was first observed over 100 years ago, after that many researchers worked on the subject postulated its physiologic role and the role in gastrointestinal diseases, but its function remains unclear. With progress of imaging methods, the nature of MTB is unveiling. In this study we investigated the effect of MTB on the gastric empting delay in functional dyspepsia （FD） and explored the mechanism. Methods A total of 60 patients with FD and 65 age- and sex-matched healthy people who served as controls were studied. With ^99mTc-DTPA labeled semi-solid fat-parched flour served as test meal, gastric empting was examined in all subjects by using single photon emission computed tomography. Test meal was designated as general （60 g fat-parched flour） or large （80 g fat-parched flour） meal. Stomach was divided into proximal and distal parts by MTB. Half gastric empting time, areas of different gastric parts, intragastric food distribution and MTB width were tested with in given times. Results Patients with FD showed a delayed gastric empting and increased intragastric residue. Global and regional gastric erupting velocity was decreased. The areas of distal stomach and MTB were significantly greater in the FD patients than in the controls. Throughout the whole test period a distal stomach-dominated food distribution was shown. Those who took a large meal had longer half gastric empting time and greater MTB area than those who took a general meal. Conclusions Gastric empting delay is related to enlarged MTB area. Some dyspeptic symptoms may be induced by abnormal distribution and increased retention of food in distal stomach. MTB, being like atriaventricular valve that controls blood flow in heart, regulates transport, distribution, and empting of food in the stomach.展开更多
文摘目的:探讨改良中医情绪疗法联合帕罗西汀在抑郁症患者中的疗效观察及对外周血T淋巴细胞亚群的影响。方法:选择2014年5月~2017年4月以抑郁症收治的90例患者作为对象,按照随机数字表法分为对照组( n =45)和观察组( n =45)。对照组采用帕罗西汀治疗,观察组在对照组基础上联合改良中医情绪疗法治疗,两组均进行1个月治疗,治疗完毕后对患者效果进行评估。采用汉密尔顿抑郁量表(HAMD)对两组患者治疗前、治疗后1个月从认知障碍、睡眠障碍、躯体性焦虑、精神性焦虑及情绪进行评估;采用酶联免疫吸附实验测定两组患者治疗前、治疗后1个月白细胞介素-2(IL-2)和肿瘤坏死因子-α(TNF-α)水平;采用流式细胞仪测定两组患者治疗前、治疗后1个月CD3 ^+、CD4 ^+、CD8 ^+及CD4 +/CD8 ^+T细胞水平;记录并统计两组治疗后恶心、口干、便秘及头晕发生率,比较两组临床疗效及目标治疗对外周血T淋巴细胞水平的影响。结果:观察组治疗后1个月认知障碍、睡眠障碍、躯体性焦虑、精神性焦虑及情绪评分均低于对照组( P <0.05);IL-2及TNF-α水平均低于对照组( P <0.05);CD3 ^+、CD4 ^+、CD4 ^+/CD8 ^+T细胞水平均高于对照组( P <0.05);CD8 ^+T细胞水平低于对照组( P <0.05)。观察组与对照组治疗后比较,恶心、口干、便秘及头晕发生率差异无统计学意义( P >0.05)。结论:将改良中医情绪疗法联合帕罗西汀用于抑郁症患者中有助于改善患者抑郁症状,降低炎症因子水平,能提高T淋巴细胞水平,值得推广。
基金Supported by Heilongjiang Provincial Project(Topic JC2018007)
文摘As one of the secondary metabolites,the isoflavones formed during the development of soybean[Glycine max(L.)Merr.]seeds.The total and individual isoflavone contents,a typical quantitative trait,were affected by significant genotypes of environments(GE)interaction and controlled by many genes with main or minor effects.In the present study,99 soybean cultivars,collected from northeastern China,were used to analyze the isoflavone performances.Genotype-genotype×environment(GGE)biplot software demonstrated an ability to provide information on genetic main effects than solely on phenotypic perform.Highperformance liquid chromatography(HPLC)system was used to extract and determine the isoflavone contents.The results indicated that most genotypes significantly varied among six tested environments.P40(Xiaolimoshidou)was the best-performed genotype with mean performance and stability for glycitein content across six different environments.P88(L-59Peking)was the super genotype with mean performance and stability on each tested environment for daidzein,genistein and the total isoflavone.E5(Gongzhuling in 2016)was the best environment for optimal environmental factor mining.P70(Charleston),P67(Baichengmoshidou)and P50(Jiunong 20)were the optimal genotypes with the highest field among 99 cultivars on each tested environment for genistein.P70(Charleston),P67(Baichengmoshidou)and P14(Hefeng 25)were the optimal genotypes with the highest field among 99 cultivars on each tested environment for daidzein.P40(Xiaolimoshidou),P45(Jinshanchamodou),P33(Dongnong 48)and P56(L-5)were the optimal genotypes with the highest field among 99 cultivars on each tested environment for glycitein.P70(Charleston)and P67(Baichengmoshidou)were the optimal genotypes with the highest field among 99 cultivars on each tested environment for the total isoflavone.GGE biplot was a rational method for stability and adaptation evaluation of soybean isoflavones,and could assist soybean breeder to select a good culture and a suitable tested site.It provided a scientific basis for the establishment of a breeding site and a selection site of soybean isoflavones.This study was valuable to identify genotypes with stable performances of isoflavones of these 99 cultivars for developing new cultivars.
文摘Background Midgastric transverse band （MTB） was first observed over 100 years ago, after that many researchers worked on the subject postulated its physiologic role and the role in gastrointestinal diseases, but its function remains unclear. With progress of imaging methods, the nature of MTB is unveiling. In this study we investigated the effect of MTB on the gastric empting delay in functional dyspepsia （FD） and explored the mechanism. Methods A total of 60 patients with FD and 65 age- and sex-matched healthy people who served as controls were studied. With ^99mTc-DTPA labeled semi-solid fat-parched flour served as test meal, gastric empting was examined in all subjects by using single photon emission computed tomography. Test meal was designated as general （60 g fat-parched flour） or large （80 g fat-parched flour） meal. Stomach was divided into proximal and distal parts by MTB. Half gastric empting time, areas of different gastric parts, intragastric food distribution and MTB width were tested with in given times. Results Patients with FD showed a delayed gastric empting and increased intragastric residue. Global and regional gastric erupting velocity was decreased. The areas of distal stomach and MTB were significantly greater in the FD patients than in the controls. Throughout the whole test period a distal stomach-dominated food distribution was shown. Those who took a large meal had longer half gastric empting time and greater MTB area than those who took a general meal. Conclusions Gastric empting delay is related to enlarged MTB area. Some dyspeptic symptoms may be induced by abnormal distribution and increased retention of food in distal stomach. MTB, being like atriaventricular valve that controls blood flow in heart, regulates transport, distribution, and empting of food in the stomach.
