目的探讨下颏抗阻力训练(chin tuck against resistance,CTAR)联合吞咽低频电刺激治疗脑卒中(cerebral stroke,CS)后吞咽障碍(dysphagia after actue stroke,DAS)患者的疗效。方法采用配对病例对照研究法选取虞城县人民医院康复科2021年...目的探讨下颏抗阻力训练(chin tuck against resistance,CTAR)联合吞咽低频电刺激治疗脑卒中(cerebral stroke,CS)后吞咽障碍(dysphagia after actue stroke,DAS)患者的疗效。方法采用配对病例对照研究法选取虞城县人民医院康复科2021年1月至2023年9月收治的84例CS后DAS患者进行回顾性研究,按治疗方案不同分为参照组(n=42)、研究组(n=42)。其中采用吞咽低频电刺激治疗的患者设为参照组,采用CTAR联合吞咽低频电刺激治疗的患者设为研究组。比较两组治疗前、治疗4周后吞咽功能障碍分级情况、标准吞咽功能评定量表(SSA)评分、功能性经口舌摄食量表(FOIS)评分、舌骨喉活动度、表面肌电图、吞咽障碍特异性生命质量量表(SWAL-QOL)评分。结果研究组治疗4周后吞咽功能障碍改善情况优于参照组(P<0.05);研究组治疗4周后SSA评分为(24.18±2.12)分,低于参照组(28.79±3.77)分,FOIS评分为(5.68±0.45)分,高于参照组(4.63±0.51)分(P<0.05);研究组治疗4周后舌骨前移、上移活动度分别为(11.47±2.55)mm、(17.38±4.59)mm,高于参照组(8.25±1.06)mm、(14.03±4.56)mm(P<0.05);研究组治疗4周后最大波幅为(725.38±55.02)V,高于参照组(605.98±49.65)V,吞咽时程为(1.11±0.15)s,短于参照组(1.33±0.21)s(P<0.05);研究组治疗4周后SWAL-QOL评分为(125.32±15.32)分,高于参照组(102.54±14.25)分(P<0.05)。结论CTAR联合吞咽低频电刺激治疗CS后DAS患者可有效提高舌骨喉活动度,改善吞咽、摄食功能,促进生活质量提升。展开更多
目的:现有研究显示,原发性痛风和高尿酸血症是一类多基因遗传性疾病,是遗传因素和环境因素共同作用的结果。但目前对痛风和高尿酸血症的遗传易感性研究尚不完善,还不能预测哪些人群易患痛风和高尿酸血症。全基因组关联分析(Genome-wide ...目的:现有研究显示,原发性痛风和高尿酸血症是一类多基因遗传性疾病,是遗传因素和环境因素共同作用的结果。但目前对痛风和高尿酸血症的遗传易感性研究尚不完善,还不能预测哪些人群易患痛风和高尿酸血症。全基因组关联分析(Genome-wide association study,GWAS)是近年来发展起来的用于识别、鉴定复杂性疾病致病易感基因的手段,通过对病人和正常对照人群的筛查,结合计算机技术和统计分析手段,可从整个基因组变异来识别、鉴定微效基因及其与相关疾病的相互作用。笔者对近几年发现的尿酸相关基因进行总结分类,为进一步认识痛风和高尿酸血症的分子机制提供依据,为进一步深入研究痛风和高尿酸血症的病因提供有益参考。展开更多
A digital modeling system method is put forward for modeling constitutive relation of geomaterial including digital image subsystem for deformation measurement, numerical modeling subsystem and numerical simulation su...A digital modeling system method is put forward for modeling constitutive relation of geomaterial including digital image subsystem for deformation measurement, numerical modeling subsystem and numerical simulation subsystem. A non-contact measurement method based on digital image processing is introduced to improve measurement of specimen deformation. Based on the method, a series of conventional tri-axial compression tests under diverse stress paths are done. Then an elasto-plastic constitutive model of soil is acquired through the numerical method of modeling constitutive law for geomaterial. Two examples of specimen deformation and ground subsidence are presented and discussed. It indicated that this method can rationally simulate the stress-strain relationship of soil, which reflects the effect of stress path on soil stress-strain relationship.展开更多
文摘目的探讨下颏抗阻力训练(chin tuck against resistance,CTAR)联合吞咽低频电刺激治疗脑卒中(cerebral stroke,CS)后吞咽障碍(dysphagia after actue stroke,DAS)患者的疗效。方法采用配对病例对照研究法选取虞城县人民医院康复科2021年1月至2023年9月收治的84例CS后DAS患者进行回顾性研究,按治疗方案不同分为参照组(n=42)、研究组(n=42)。其中采用吞咽低频电刺激治疗的患者设为参照组,采用CTAR联合吞咽低频电刺激治疗的患者设为研究组。比较两组治疗前、治疗4周后吞咽功能障碍分级情况、标准吞咽功能评定量表(SSA)评分、功能性经口舌摄食量表(FOIS)评分、舌骨喉活动度、表面肌电图、吞咽障碍特异性生命质量量表(SWAL-QOL)评分。结果研究组治疗4周后吞咽功能障碍改善情况优于参照组(P<0.05);研究组治疗4周后SSA评分为(24.18±2.12)分,低于参照组(28.79±3.77)分,FOIS评分为(5.68±0.45)分,高于参照组(4.63±0.51)分(P<0.05);研究组治疗4周后舌骨前移、上移活动度分别为(11.47±2.55)mm、(17.38±4.59)mm,高于参照组(8.25±1.06)mm、(14.03±4.56)mm(P<0.05);研究组治疗4周后最大波幅为(725.38±55.02)V,高于参照组(605.98±49.65)V,吞咽时程为(1.11±0.15)s,短于参照组(1.33±0.21)s(P<0.05);研究组治疗4周后SWAL-QOL评分为(125.32±15.32)分,高于参照组(102.54±14.25)分(P<0.05)。结论CTAR联合吞咽低频电刺激治疗CS后DAS患者可有效提高舌骨喉活动度,改善吞咽、摄食功能,促进生活质量提升。
基金Project(52001140) supported by the National Natural Science Foundation of ChinaProjects(GY2021003, GY2021020) supported by the Key Research and Development Program of Zhenjiang City,China+1 种基金Project(SJCX23_2186) supported by Postgraduate Research&Practice Innovation Program of Jiangsu Province,ChinaProject(202310289013H) supported by Undergaduate Innovation and Entrepreneurship Training Program of Jiangsu Province,China。
文摘目的:现有研究显示,原发性痛风和高尿酸血症是一类多基因遗传性疾病,是遗传因素和环境因素共同作用的结果。但目前对痛风和高尿酸血症的遗传易感性研究尚不完善,还不能预测哪些人群易患痛风和高尿酸血症。全基因组关联分析(Genome-wide association study,GWAS)是近年来发展起来的用于识别、鉴定复杂性疾病致病易感基因的手段,通过对病人和正常对照人群的筛查,结合计算机技术和统计分析手段,可从整个基因组变异来识别、鉴定微效基因及其与相关疾病的相互作用。笔者对近几年发现的尿酸相关基因进行总结分类,为进一步认识痛风和高尿酸血症的分子机制提供依据,为进一步深入研究痛风和高尿酸血症的病因提供有益参考。
文摘A digital modeling system method is put forward for modeling constitutive relation of geomaterial including digital image subsystem for deformation measurement, numerical modeling subsystem and numerical simulation subsystem. A non-contact measurement method based on digital image processing is introduced to improve measurement of specimen deformation. Based on the method, a series of conventional tri-axial compression tests under diverse stress paths are done. Then an elasto-plastic constitutive model of soil is acquired through the numerical method of modeling constitutive law for geomaterial. Two examples of specimen deformation and ground subsidence are presented and discussed. It indicated that this method can rationally simulate the stress-strain relationship of soil, which reflects the effect of stress path on soil stress-strain relationship.
