目的:系统评价利伐沙班对比低分子肝素预防髋骨骨折患者发生静脉血栓栓塞(VTE)的有效性和安全性,为临床应用提供循证参考。方法:计算机检索自建库起至2018年6月收录于Cochrane图书馆、PubMed、Embase、中国期刊全文数据库、维普网、万...目的:系统评价利伐沙班对比低分子肝素预防髋骨骨折患者发生静脉血栓栓塞(VTE)的有效性和安全性,为临床应用提供循证参考。方法:计算机检索自建库起至2018年6月收录于Cochrane图书馆、PubMed、Embase、中国期刊全文数据库、维普网、万方数据的文献,收集利伐沙班(试验组)对比低分子肝素(对照组)预防髋骨骨折患者发生VTE的随机对照试验(RCT),对符合标准的文献进行资料提取,并采用Cochrane系统评价员手册5.1.0进行质量评价后,采用Rev Man 5.3统计软件对深静脉血栓形成(DVT)发生率、术后引流量、活化部分凝血活酶时间(APTT)水平、凝血酶原时间(PT)及药品不良反应(ADR)发生率进行Meta分析。结果:共纳入8项RCT,合计949例患者。Meta分析结果显示,与低分子肝素相比,利伐沙班能显著降低患者的DVT发生率[RR=0.55,95%CI(0.36,0.83),P=0.004];两组患者的术后引流量[MD=-0.24,95%CI(-5.27,4.8),P=0.93]、APTT[MD=0.56,95%CI(-0.75,1.86),P=0.40]、PT[MD=0.04,95%CI(-0.03,0.11),P=0.25]及ADR发生率[RR=1.73,95%CI(0.15,20.48),P=0.66]比较,差异均无统计学意义。结论:利伐沙班对髋骨骨折患者发生VTE的预防效果优于低分子肝素,且安全性相当。展开更多
By using drilling,high-precision 3 D seismic data,data of geochemistry,logging and testing,the reservoir characteristics and accumulation conditions of the KL6-1 lithologic oilfield in the Laibei Low Uplift in the Boh...By using drilling,high-precision 3 D seismic data,data of geochemistry,logging and testing,the reservoir characteristics and accumulation conditions of the KL6-1 lithologic oilfield in the Laibei Low Uplift in the Bohai Sea are examined comprehensively.The study shows that:KL6-1 oilfield is a monolithic,high-quality,large-scale Neogene lithologic oilfield featuring shallow reservoir depth,high productivity,concentrated oil-bearing intervals,large oil-bearing area,and high reserve abundance;hydrocarbon source supply from two directions provides a sufficient material basis for the formation of large oil field;two types of"inherited structural ridge"developed under the effect of block rotation,late active faults formed by Neotectonic movement,and widely distributed contiguous sand bodies provide an efficient oil and gas transportation system for the large-scale accumulation of oil and gas;contiguous channel and lacustrine lowstand system sand bodies developed in low accommodation condition provide the basic condition for the formation of large-scale lithologic traps;deep formations structural ridge,faults(dominant migration pathways)and large-scale superimposed contiguous sand bodies constitute a"vine type"oil and gas migration and accumulation system in the Laibei Low Uplift,which is conducive to the formation of large-scale and high-abundance lithologic reservoir in this area.The successful discovery of KL6-1,100 million ton reserve order lithologic oil field,has revealed the exploration potential of Neogene large lithologic reservoirs in Bohai Sea,expanded the exploration field,and also has certain reference significance for the exploration of large lithologic reservoirs in similar areas.展开更多
目的系统评价德谷胰岛素和甘精胰岛素治疗2型糖尿病(T2DM)的疗效与安全性,为临床提供循证参考。方法计算机检索PubMed、EMBASE、The Cochrane Library、Web of Science、中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、万方...目的系统评价德谷胰岛素和甘精胰岛素治疗2型糖尿病(T2DM)的疗效与安全性,为临床提供循证参考。方法计算机检索PubMed、EMBASE、The Cochrane Library、Web of Science、中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、万方数据库及维普信息资源系统(VIP),收集比较德谷胰岛素与甘精胰岛素治疗T2DM的疗效与安全性的随机对照试验(RCT),检索时限均为建库至2018年9月。对符合纳入标准的文献进行资料提取,并对纳入研究进行质量评价,采用Rev Man 5.3统计软件进行Meta分析。结果共纳入10项RCTs,共13119例患者。Meta分析结果显示,德谷胰岛素降低空腹血糖(FPG)水平优于甘精胰岛素[WMD=-0.30,95%CI(-0.47^-0.13),P=0.0006],但对糖化血红蛋白(HbA1c)达标(<7%)影响,二者差异无统计学意义[RR=0.97,95%CI(0.91~1.03),P=0.36]。甘精胰岛素与德谷胰岛素在低血糖发生率[RR=0.93,95%CI(0.86~1.01),P=0.08]、主要不良心血管事件(MACE)发生率[RR=0.92,95%CI(0.80~1.06),P=0.23]方面比较,差异均无统计学意义;德谷胰岛素的夜间低血糖发生率[RR=0.79,95%CI(0.71~0.87),P<0.01]、严重低血糖发生率[RR=0.73,95%CI(0.62~0.85),P=0.0001]均低于甘精胰岛素。结论德谷胰岛素治疗T2DM的疗效与安全性优于甘精胰岛素。展开更多
目的系统评价基于索磷布韦的直接抗病毒药物(DDAs)治疗基因1型慢性丙型肝炎的疗效与安全性。方法计算机检索PubMed、EMBASE、The Cochrane Library、Web of Science、中国知网、中国生物医学文献数据库、万方数据知识服务平台和维普中...目的系统评价基于索磷布韦的直接抗病毒药物(DDAs)治疗基因1型慢性丙型肝炎的疗效与安全性。方法计算机检索PubMed、EMBASE、The Cochrane Library、Web of Science、中国知网、中国生物医学文献数据库、万方数据知识服务平台和维普中文期刊服务平台,收集索磷布韦治疗基因1型慢性丙型肝炎疗效与安全性的随机对照试验(RCT),检索时限均为从建库至2018年9月。对符合纳入标准的文献进行资料提取,并对纳入研究进行质量评价,采用RevMan 5.3统计软件进行Meta分析。结果共纳入8项RCT,共计2541例患者。Meta分析结果显示,索磷布韦+直接抗病毒药物与索磷布韦+直接抗病毒药物+利巴韦林在快速病毒学应答(RVR)获得率(RR=1.01,95%CI:0.99~1.02,P=0.310)、12周持续病毒学应答(SVR12)获得率(RR=1.01,95%CI:0.99~1.02,P=0.380)方面比较,差异均无统计学意义。索磷布韦+直接抗病毒药物总不良反应发生率(RR=0.89,95%CI:0.85~0.92,P<0.001)、一般不良反应发生率(疲劳(RR=0.63,95%CI:0.51~0.77,P<0.001)、头痛(RR=0.82,95%CI:0.72~0.94,P=0.004)、恶心(RR=0.61,95%CI:0.50~0.74,P<0.001)均低于索磷布韦+直接抗病毒药物+利巴韦林。索磷布韦+直接抗病毒药物与索磷布韦+直接抗病毒药物+利巴韦林在严重不良反应发生率(RR=1.58,95%CI:1.01~2.46,P=0.050)方面比较,差异无统计学意义,但索磷布韦+直接抗病毒药物血红蛋白降低发生率(<100g/L)显著低于索磷布韦+直接抗病毒药物+利巴韦林(RR=0.11,95%CI:0.06~0.22,P<0.001)。结论索磷布韦+直接抗病毒药物治疗基因1型慢性丙型肝炎与索磷布韦+直接抗病毒药物+利巴韦林疗效相当,但安全性更高。展开更多
文摘目的:系统评价利伐沙班对比低分子肝素预防髋骨骨折患者发生静脉血栓栓塞(VTE)的有效性和安全性,为临床应用提供循证参考。方法:计算机检索自建库起至2018年6月收录于Cochrane图书馆、PubMed、Embase、中国期刊全文数据库、维普网、万方数据的文献,收集利伐沙班(试验组)对比低分子肝素(对照组)预防髋骨骨折患者发生VTE的随机对照试验(RCT),对符合标准的文献进行资料提取,并采用Cochrane系统评价员手册5.1.0进行质量评价后,采用Rev Man 5.3统计软件对深静脉血栓形成(DVT)发生率、术后引流量、活化部分凝血活酶时间(APTT)水平、凝血酶原时间(PT)及药品不良反应(ADR)发生率进行Meta分析。结果:共纳入8项RCT,合计949例患者。Meta分析结果显示,与低分子肝素相比,利伐沙班能显著降低患者的DVT发生率[RR=0.55,95%CI(0.36,0.83),P=0.004];两组患者的术后引流量[MD=-0.24,95%CI(-5.27,4.8),P=0.93]、APTT[MD=0.56,95%CI(-0.75,1.86),P=0.40]、PT[MD=0.04,95%CI(-0.03,0.11),P=0.25]及ADR发生率[RR=1.73,95%CI(0.15,20.48),P=0.66]比较,差异均无统计学意义。结论:利伐沙班对髋骨骨折患者发生VTE的预防效果优于低分子肝素,且安全性相当。
基金Supported by the China National Science and Technology Major Project(2016ZX05024-003)。
文摘By using drilling,high-precision 3 D seismic data,data of geochemistry,logging and testing,the reservoir characteristics and accumulation conditions of the KL6-1 lithologic oilfield in the Laibei Low Uplift in the Bohai Sea are examined comprehensively.The study shows that:KL6-1 oilfield is a monolithic,high-quality,large-scale Neogene lithologic oilfield featuring shallow reservoir depth,high productivity,concentrated oil-bearing intervals,large oil-bearing area,and high reserve abundance;hydrocarbon source supply from two directions provides a sufficient material basis for the formation of large oil field;two types of"inherited structural ridge"developed under the effect of block rotation,late active faults formed by Neotectonic movement,and widely distributed contiguous sand bodies provide an efficient oil and gas transportation system for the large-scale accumulation of oil and gas;contiguous channel and lacustrine lowstand system sand bodies developed in low accommodation condition provide the basic condition for the formation of large-scale lithologic traps;deep formations structural ridge,faults(dominant migration pathways)and large-scale superimposed contiguous sand bodies constitute a"vine type"oil and gas migration and accumulation system in the Laibei Low Uplift,which is conducive to the formation of large-scale and high-abundance lithologic reservoir in this area.The successful discovery of KL6-1,100 million ton reserve order lithologic oil field,has revealed the exploration potential of Neogene large lithologic reservoirs in Bohai Sea,expanded the exploration field,and also has certain reference significance for the exploration of large lithologic reservoirs in similar areas.
文摘目的系统评价德谷胰岛素和甘精胰岛素治疗2型糖尿病(T2DM)的疗效与安全性,为临床提供循证参考。方法计算机检索PubMed、EMBASE、The Cochrane Library、Web of Science、中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、万方数据库及维普信息资源系统(VIP),收集比较德谷胰岛素与甘精胰岛素治疗T2DM的疗效与安全性的随机对照试验(RCT),检索时限均为建库至2018年9月。对符合纳入标准的文献进行资料提取,并对纳入研究进行质量评价,采用Rev Man 5.3统计软件进行Meta分析。结果共纳入10项RCTs,共13119例患者。Meta分析结果显示,德谷胰岛素降低空腹血糖(FPG)水平优于甘精胰岛素[WMD=-0.30,95%CI(-0.47^-0.13),P=0.0006],但对糖化血红蛋白(HbA1c)达标(<7%)影响,二者差异无统计学意义[RR=0.97,95%CI(0.91~1.03),P=0.36]。甘精胰岛素与德谷胰岛素在低血糖发生率[RR=0.93,95%CI(0.86~1.01),P=0.08]、主要不良心血管事件(MACE)发生率[RR=0.92,95%CI(0.80~1.06),P=0.23]方面比较,差异均无统计学意义;德谷胰岛素的夜间低血糖发生率[RR=0.79,95%CI(0.71~0.87),P<0.01]、严重低血糖发生率[RR=0.73,95%CI(0.62~0.85),P=0.0001]均低于甘精胰岛素。结论德谷胰岛素治疗T2DM的疗效与安全性优于甘精胰岛素。
