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Evaluation of groundwater quality and pollution in Daqing Oilfield
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作者 WU Ting-wen wang Li-huan +1 位作者 wang lin-shu KONG Qing-xuan 《Journal of Groundwater Science and Engineering》 2018年第1期40-48,共9页
Daqing Oilfield is located in the northeast of Songnen Plain in Daqing City, Heilongjiang Province, which is a petrochemical industry gathering place based on petroleum refining, chemical industry, chemical fiber and ... Daqing Oilfield is located in the northeast of Songnen Plain in Daqing City, Heilongjiang Province, which is a petrochemical industry gathering place based on petroleum refining, chemical industry, chemical fiber and fertilizer. In recent years, the quantity demand of petroleum and petrochemical production for groundwater in Daqing Oilfield is growing, and it's of great significance to analyze and study the quality and pollution degree of groundwater for groundwater exploitation, utilization and protection. In this paper, groundwater quality of Daqing Oilfield evaluated by Nemerow Index is poor, and most points are Class IV groundwater; When evaluating groundwater pollution by hierarchical ladder method, the results show that the severe and extremely severe pollution points account for 34.48% in shallow phreatic water and 20% in deep confined water, showing that shallow groundwater is more seriously polluted than the deep. The main components influencing the quality of groundwater in the study area are total hardness, total dissolved solids, Cl^-, SO_4^(2-) and so on, which are affected by both the native environment and human activities; The main pollution components in groundwater are nitrite and nitrate nitrogen which are affected by human activities. Daqing Oilfield groundwater pollution is characterized by inorganic pollution, while organic components related to human activities contribute less to the groundwater pollution currently. 展开更多
关键词 DAQING OILFIELD GROUNDWATER QUALITY GROUNDWATER POLLUTION EVALUATION
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靶向Trop-2的抗体偶联药物:戈沙妥珠单抗 被引量:4
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作者 王浩 黄佳 +5 位作者 钟薇 陈玲 伏箫燕 韩梦婷 王麟书 陈岷 《中国新药与临床杂志》 CAS CSCD 北大核心 2023年第8期498-502,共5页
戈沙妥珠单抗是全球首款由抗人滋养层细胞表面抗原2(Trop-2)h RS7 IgG1κ抗体与拓扑异构酶Ⅰ抑制剂SN-38(伊立替康的活性代谢物)通过专有的可水解连接子偶联而成的抗体偶联药物。其于2020年和2021年分别获美国食品和药物管理局批准用于... 戈沙妥珠单抗是全球首款由抗人滋养层细胞表面抗原2(Trop-2)h RS7 IgG1κ抗体与拓扑异构酶Ⅰ抑制剂SN-38(伊立替康的活性代谢物)通过专有的可水解连接子偶联而成的抗体偶联药物。其于2020年和2021年分别获美国食品和药物管理局批准用于三阴性乳腺癌和尿路上皮癌患者的治疗,并于2022年6月获我国药品监督管理局批准,用于既往至少接受过两种系统治疗(其中至少一种治疗针对转移性疾病)的不可切除的局部晚期或转移性三阴性乳腺癌成人患者。临床研究表明,戈沙妥珠单抗在多种上皮癌患者中均具有较好的抗癌疗效,且安全性良好。 展开更多
关键词 戈沙妥珠单抗 三阴性乳腺癌 泌尿系肿瘤 临床研究
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