Two new 2-carboxymethyl-3-hexyl-maleic anhydride derivatives,arthrianhydride A(1)and B(2),along with three known compounds 3-5,were isolated from the fermentation broth of a grasshopper-associated fungus Arthrinium sp...Two new 2-carboxymethyl-3-hexyl-maleic anhydride derivatives,arthrianhydride A(1)and B(2),along with three known compounds 3-5,were isolated from the fermentation broth of a grasshopper-associated fungus Arthrinium sp.NF2410.The structures of new compounds 1 and 2 were determined based on the analysis of the HR-ESI-MS and NMR spectroscopic data.Furthermore,compounds 1 and 2 were evaluated on inhibitory activity against the enzyme SHP2 and both of them showed moderate inhibitory activity against SHP2.展开更多
基金supported by the Ministry of Science and Technology(Nos.2018YFC1706200 and 2018YFA.902000)the National Natural Science Foundation of China(Nos.81925033,21861142005,81773591,21761142001,81673333,21661140001,and 91853109)。
文摘Two new 2-carboxymethyl-3-hexyl-maleic anhydride derivatives,arthrianhydride A(1)and B(2),along with three known compounds 3-5,were isolated from the fermentation broth of a grasshopper-associated fungus Arthrinium sp.NF2410.The structures of new compounds 1 and 2 were determined based on the analysis of the HR-ESI-MS and NMR spectroscopic data.Furthermore,compounds 1 and 2 were evaluated on inhibitory activity against the enzyme SHP2 and both of them showed moderate inhibitory activity against SHP2.
