目的:探究鼻内窥镜微创手术治疗鼻窦炎的疗效及对血清中嗜酸性粒细胞阳离子蛋白(eosinophile cationic protein,ECP)、高迁移率族蛋白-1(high mobility group protein B1,HMGB1)、白细胞介素-1β(interleukin-1β,IL-1β)、白细胞介素-2...目的:探究鼻内窥镜微创手术治疗鼻窦炎的疗效及对血清中嗜酸性粒细胞阳离子蛋白(eosinophile cationic protein,ECP)、高迁移率族蛋白-1(high mobility group protein B1,HMGB1)、白细胞介素-1β(interleukin-1β,IL-1β)、白细胞介素-21(interleukin-21,IL-21)的影响。方法:选择2019年1月至2020年10月来我院就诊的鼻窦炎患者163例,按照随机数表法分成观察组(n=81)和对照组(n=82),对照组采用微波热凝手术治疗,观察组采用鼻内窥镜微创手术治疗,两组均随访3个月,比较两组治疗3个月后的临床疗效,治疗前后采用视觉模拟量表(visual analogue scale,VAS)评估患者鼻窦炎主观症状,采用Lund-Kennedy内镜评分评估鼻内镜下各黏膜形态,采用鼻腔鼻窦结局测试-20评分(sinonasal outcometest-20,SNOT-20)评估患者生活质量,并比较两组治疗前后的ECP、HMGB1、IL-1β、IL-21水平。结果:治疗后,观察组患者的总有效率为92.59%,高于对照组的81.71%(P<0.05);治疗后,观察组均流涕、鼻塞、面颊部疼痛、头痛、嗅觉减退的VAS评分为(2.03±0.52)分、(2.15±0.58)分、(1.24±0.37)分、(0.96±0.32)分、(1.25±0.31)分均低于对照组的(3.45±0.84)分、(3.21±0.74)分、(2.08±0.56)分、(1.36±0.41)分、(2.62±0.48)分(P<0.05);治疗后,观察组Lund-Kennedy评分、SNOT-20评分分别为(1.51±0.42)分、(2.08±0.62)分,均低于对照组的(2.52±0.67)分、(3.61±0.86)分(P<0.05);治疗后,观察组的ECP、HMGB1、IL-1β、IL-21水平分别为(4.23±1.08)ng/L、(64.25±6.13)μg/L、(30.25±4.36)pg/mL、(72.16±12.34)pg/mL,均低于对照组的(5.46±1.31)ng/L、(72.18±7.29)μg/L、(38.47±5.19)pg/mL、(86.25±14.17)pg/mL(P<0.05)。结论:鼻内窥镜微创手术治疗鼻窦炎疗效好,能够有效改善患者的临床症状,降低患者的变态反应及炎性水平,提高患者的生活质量。展开更多
We report the successful synthesis of Ge clusters embedded in a-SiNy:H matrix prepared by the plasma enhanced chemical vapor deposition(PECVD)method.Chemical and microstructural characteristics of this granular thin f...We report the successful synthesis of Ge clusters embedded in a-SiNy:H matrix prepared by the plasma enhanced chemical vapor deposition(PECVD)method.Chemical and microstructural characteristics of this granular thin film were analyzed using the infrared absorption,x-ray diffraction,Raman scattering,and transmission electron microscopy.Finally we discuss briefly the synthesis mechanism of this new material.展开更多
文摘目的:探究鼻内窥镜微创手术治疗鼻窦炎的疗效及对血清中嗜酸性粒细胞阳离子蛋白(eosinophile cationic protein,ECP)、高迁移率族蛋白-1(high mobility group protein B1,HMGB1)、白细胞介素-1β(interleukin-1β,IL-1β)、白细胞介素-21(interleukin-21,IL-21)的影响。方法:选择2019年1月至2020年10月来我院就诊的鼻窦炎患者163例,按照随机数表法分成观察组(n=81)和对照组(n=82),对照组采用微波热凝手术治疗,观察组采用鼻内窥镜微创手术治疗,两组均随访3个月,比较两组治疗3个月后的临床疗效,治疗前后采用视觉模拟量表(visual analogue scale,VAS)评估患者鼻窦炎主观症状,采用Lund-Kennedy内镜评分评估鼻内镜下各黏膜形态,采用鼻腔鼻窦结局测试-20评分(sinonasal outcometest-20,SNOT-20)评估患者生活质量,并比较两组治疗前后的ECP、HMGB1、IL-1β、IL-21水平。结果:治疗后,观察组患者的总有效率为92.59%,高于对照组的81.71%(P<0.05);治疗后,观察组均流涕、鼻塞、面颊部疼痛、头痛、嗅觉减退的VAS评分为(2.03±0.52)分、(2.15±0.58)分、(1.24±0.37)分、(0.96±0.32)分、(1.25±0.31)分均低于对照组的(3.45±0.84)分、(3.21±0.74)分、(2.08±0.56)分、(1.36±0.41)分、(2.62±0.48)分(P<0.05);治疗后,观察组Lund-Kennedy评分、SNOT-20评分分别为(1.51±0.42)分、(2.08±0.62)分,均低于对照组的(2.52±0.67)分、(3.61±0.86)分(P<0.05);治疗后,观察组的ECP、HMGB1、IL-1β、IL-21水平分别为(4.23±1.08)ng/L、(64.25±6.13)μg/L、(30.25±4.36)pg/mL、(72.16±12.34)pg/mL,均低于对照组的(5.46±1.31)ng/L、(72.18±7.29)μg/L、(38.47±5.19)pg/mL、(86.25±14.17)pg/mL(P<0.05)。结论:鼻内窥镜微创手术治疗鼻窦炎疗效好,能够有效改善患者的临床症状,降低患者的变态反应及炎性水平,提高患者的生活质量。
基金the National Natural Science Foundation of China.
文摘We report the successful synthesis of Ge clusters embedded in a-SiNy:H matrix prepared by the plasma enhanced chemical vapor deposition(PECVD)method.Chemical and microstructural characteristics of this granular thin film were analyzed using the infrared absorption,x-ray diffraction,Raman scattering,and transmission electron microscopy.Finally we discuss briefly the synthesis mechanism of this new material.
