Background Atrioventricular block(AVB)is associated with adverse events even cardiac death. Serum uric acid(SUA)might lead to cadiovascular disease including arrhythmia and SUA lowering therapy could lower the risk. B...Background Atrioventricular block(AVB)is associated with adverse events even cardiac death. Serum uric acid(SUA)might lead to cadiovascular disease including arrhythmia and SUA lowering therapy could lower the risk. But the study of the association between AVB and SUA is rare at present. Method Sixty-four patients with AVB from Sep 2017 to Sep 2018 were enrolled as case group and another 64 patients in the same period were enrolled as control group. The levels of serum uric acid(SUA)and related parameters were compared between the two groups. Results The level of SUA was significantly higher in case group than in control group(402.13±140.08 vs. 351.17±87.81,P=0.015). HUA was associated with AVB significantly(OR 2.863,95%CI1.305～6.279,P=0.009),even after adjustment for confounding factors(OR 2.609,95%CI 1.081～6.296,P=0.033). For the comparison among AVB subgroups,only the association between HUA and Ⅲ-degree subtypes was found significantly(OR 3.411,95%CI 1.452～8.016,P=0.005). Conclusion HUA is positively associated with AVB independent of other potential confounding factors. But further analysis of different subtypes indicated that only the association between HUA and Ⅲ-degree AVB was found significant.展开更多
Background Renal denervation has a tortuous history.Significant reductions in blood pressure following denervation of the renal artery were observed in early trials,but subsequent denervation under sham surgery was fo...Background Renal denervation has a tortuous history.Significant reductions in blood pressure following denervation of the renal artery were observed in early trials,but subsequent denervation under sham surgery was found to be neutral.Methods This study was performed according to search results by CNKI,WANFANG DATA,EMBASE database,Pubmed,Medline,the Cochrane Central Register of Controlled Trials,Clinicaltrials.gov,and World Health Organization International Clinical Trials Registry Platform from database inception to June 20,2019.For continuous outcomes,heterogeneity were assessed by Cochran’s Q test and random-effect models weighted for the inverse of the variance.Dichotomous data were analyzed using relative risk(RR)with 95%CIs.Safety was assessed by assessing the risk of major adverse events from stratified contingency tables.Results 10 randomized controlled trials with a total of 1323 individuals were included in the quantitative analysis.Pooled analyses indicated that renal denervation was associated with a significantly greater reduction of office systolic blood pressure[mean difference(MD):-5.61 mm Hg,95%CI:-9.03 to-2.19,Z=3.21,P=0.0001]and 24-hour systolic blood pressure(MD:-4.40 mmHg,95%CI:-14.03 to-3.83,Z=5.09,P<0.00001)than controls.Renal denervation was not associated with an increased risk of major adverse events(RR:1.12,95%CI:0.72 to 1.64,Z=0.66,P=0.51),and estimated glomerular filtration rate(e GFR)[MD:0.35 mL/(min·1.73 m2),95%CI:-2.05 to2.74,Z=0.28,P=0.78]from baseline to 6 months is statistically insignificant with significant heterogeneity.Conclusions In selected resistant hypertension patients maintained on antihypertensive drugs,renal denervation with the SYMPLICITY systems did significantly decrease blood pressure.Renal denervation was not associated with an increased risk of major adverse events.展开更多
基金supported by National Natural Science Foundation of China(No.81641058)
文摘Background Atrioventricular block(AVB)is associated with adverse events even cardiac death. Serum uric acid(SUA)might lead to cadiovascular disease including arrhythmia and SUA lowering therapy could lower the risk. But the study of the association between AVB and SUA is rare at present. Method Sixty-four patients with AVB from Sep 2017 to Sep 2018 were enrolled as case group and another 64 patients in the same period were enrolled as control group. The levels of serum uric acid(SUA)and related parameters were compared between the two groups. Results The level of SUA was significantly higher in case group than in control group(402.13±140.08 vs. 351.17±87.81,P=0.015). HUA was associated with AVB significantly(OR 2.863,95%CI1.305～6.279,P=0.009),even after adjustment for confounding factors(OR 2.609,95%CI 1.081～6.296,P=0.033). For the comparison among AVB subgroups,only the association between HUA and Ⅲ-degree subtypes was found significantly(OR 3.411,95%CI 1.452～8.016,P=0.005). Conclusion HUA is positively associated with AVB independent of other potential confounding factors. But further analysis of different subtypes indicated that only the association between HUA and Ⅲ-degree AVB was found significant.
基金the National Natural Science Foundation of China(No.81641058)Scientific Research Fund of Sichuan Provincial Education Department(No.17TD0011)National Clinical Key Specialist Construction and Cultivation Department Special Scientific Research Project(No.CYFY2017GLPX01)。
文摘Background Renal denervation has a tortuous history.Significant reductions in blood pressure following denervation of the renal artery were observed in early trials,but subsequent denervation under sham surgery was found to be neutral.Methods This study was performed according to search results by CNKI,WANFANG DATA,EMBASE database,Pubmed,Medline,the Cochrane Central Register of Controlled Trials,Clinicaltrials.gov,and World Health Organization International Clinical Trials Registry Platform from database inception to June 20,2019.For continuous outcomes,heterogeneity were assessed by Cochran’s Q test and random-effect models weighted for the inverse of the variance.Dichotomous data were analyzed using relative risk(RR)with 95%CIs.Safety was assessed by assessing the risk of major adverse events from stratified contingency tables.Results 10 randomized controlled trials with a total of 1323 individuals were included in the quantitative analysis.Pooled analyses indicated that renal denervation was associated with a significantly greater reduction of office systolic blood pressure[mean difference(MD):-5.61 mm Hg,95%CI:-9.03 to-2.19,Z=3.21,P=0.0001]and 24-hour systolic blood pressure(MD:-4.40 mmHg,95%CI:-14.03 to-3.83,Z=5.09,P<0.00001)than controls.Renal denervation was not associated with an increased risk of major adverse events(RR:1.12,95%CI:0.72 to 1.64,Z=0.66,P=0.51),and estimated glomerular filtration rate(e GFR)[MD:0.35 mL/(min·1.73 m2),95%CI:-2.05 to2.74,Z=0.28,P=0.78]from baseline to 6 months is statistically insignificant with significant heterogeneity.Conclusions In selected resistant hypertension patients maintained on antihypertensive drugs,renal denervation with the SYMPLICITY systems did significantly decrease blood pressure.Renal denervation was not associated with an increased risk of major adverse events.
