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细胞外核苷酸对免疫细胞的调节作用 被引量:1
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作者 王秋吉 杨启鑫 +1 位作者 柴艳敏(指导) 单春华 《中国免疫学杂志》 CAS CSCD 北大核心 2021年第2期249-253,共5页
细胞释放到胞外空间的核苷酸称为胞外核苷酸,其浓度受多种水解酶调节,不同浓度的胞外核苷酸作用不同。胞外核苷酸及其衍生核苷与不同的嘌呤受体结合,激活复杂的信号传导网络,参与调控多种生理和病理过程,特别是胞外三磷酸腺苷(ATP)是免... 细胞释放到胞外空间的核苷酸称为胞外核苷酸,其浓度受多种水解酶调节,不同浓度的胞外核苷酸作用不同。胞外核苷酸及其衍生核苷与不同的嘌呤受体结合,激活复杂的信号传导网络,参与调控多种生理和病理过程,特别是胞外三磷酸腺苷(ATP)是免疫应答的关键介质,作为重要动态信号参与调控过程。本文综述了胞外核苷酸对巨噬细胞、树突状细胞(DCs)和淋巴细胞等免疫细胞的调节作用,并对胞外核苷酸在临床上的应用进行了展望。 展开更多
关键词 细胞外核苷酸 免疫细胞 嘌呤受体
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Stanford A型主动脉夹层术后不良事件风险预测模型的建立
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作者 王秋吉 杨珏 +3 位作者 邝俊涛 冯玮琪 于长江 范瑞新 《岭南心血管病杂志》 CAS 2022年第6期491-496,共6页
目的分析急性Stanford A型主动脉夹层术后发生不良事件的独立危险因素,并建立风险预测模型。方法回顾性收集2017年9月至2020年3月连续就诊于广东省人民医院并行外科手术的342例急性Stanford A型主动脉夹层患者的围术期临床资料,根据患... 目的分析急性Stanford A型主动脉夹层术后发生不良事件的独立危险因素,并建立风险预测模型。方法回顾性收集2017年9月至2020年3月连续就诊于广东省人民医院并行外科手术的342例急性Stanford A型主动脉夹层患者的围术期临床资料,根据患者术后30 d内是否发生不良事件将其分为发生组和未发生组,并按3∶1的比例随机分为建模组和验证组,通过Logistics回归分析进行统计并建立预测模型,在验证组中对预测模型进行效能评价并进行10倍交叉验证。结果术后发生不良事件104例,死亡24例,发生率分别为30.4%和7.0%。多因素Logistic回归分析的以下变量被纳入模型:年龄、术前天门冬氨酸氨基转移酶浓度≥120 U/L、室间隔厚度≥12 mm、同期行冠状动脉旁路移植术、体外循环时间≥250 min、延迟关胸,并据此建立预测模型。建模组受试者工作特征曲线(receiver operating characteristic curve,ROC)下面积=0.755(95%CI:0.686~0.823),通过Hosmer-Lemeshow检验发现,观测值和预测值的分离度差异无统计学意义(χ^(2)=7.594,df=8,P=0.474)。验证组ROC曲线下面积为0.714(95%CI:0.561~0.867),该组Hosmer-Lemeshow检验得出P=0.460(χ^(2)=7.735,df=8)。10倍交叉验证的平均ROC曲线下面积为0.716(0.507~0.841)。Hosmer-Lemeshow拟合优度检验P=0.474。结论本研究建立的Logistic模型能够成功预测Stanford A型主动脉夹层术后不良事件的发生风险且预测效能满意。 展开更多
关键词 主动脉夹层 术后不良事件 危险因素 预测模型
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Analysis on the Orientation of Marriage Value in the 18th-19th Century of England through Pride and Prejudice
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作者 wang qiu-ji 《科技视界》 2013年第24期176-178,共3页
"It is truth universally acknowledged that a single man in possession of a good fortune,must be in want of a wife." Almost two centuries later,the deep impression on readers left by the opening sentence of P... "It is truth universally acknowledged that a single man in possession of a good fortune,must be in want of a wife." Almost two centuries later,the deep impression on readers left by the opening sentence of Pride and Prejudice has not decreased because of their changing literary taste.Jane Austin,the author of Pride and Prejudice,was one of the famous realistic writers in English literature in the nineteenth century.Pride and Prejudice is Austin's representative work.There were no earthshaking events,no dreadful disasters,no sharp contradictions and no romantic legends in Authin's novels.Time and space were small in her novels.She wrote how a marriageable woman could find a satisfactory husband.She described many kinds of love and marriage of different women.She expressed her own original views of marriage in her works.In Pride and Prejudice Austin wrote four marriage types: ideal Elizabeth and Darcy,realistic Charlotte and Collins,felicitous Jane and Bingley,unhappy Lydiard Wickham.She pointed out emphatically economic consideration is the bonds of wedlock and love.She said marriage is not determined by property and family status.It is unwise to marry without money,but it is wrong to marry for money;the marriage settled by love is happy and ideal.The thesis explicates that Austin's view of marriage was progressive,advocated by her focus on the equality between men and women.She emphasized marriage should be of equal importance both by love and by economic consideration,but love plays the guiding role.She revealed the connotation of marriage.She also analyses the marriage value in the 18th-19th century.Her exposure is of great realistic significance to the society today. 展开更多
关键词 英语教学 教学方法 课堂教学 阅读教学
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新型经导管三尖瓣介入瓣膜的耐久性测试
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作者 王秋吉 肖硕 +5 位作者 钟丽珊 华林斌 张朝龙 柯英杰 庞善文 黄焕雷 《广东医学》 CAS 2024年第10期1221-1225,共5页
目的测试新型牛心包三尖瓣介入瓣膜的耐久性。方法以19 mm、23 mm和29 mm三个不同型号的牛心包瓣叶作为测试瓣叶;以Edwards Life Sciences生产的对应型号的牛心包瓣作为对照组(每个测试型号包括3个测试瓣和1个对照瓣)。在测试前对所有... 目的测试新型牛心包三尖瓣介入瓣膜的耐久性。方法以19 mm、23 mm和29 mm三个不同型号的牛心包瓣叶作为测试瓣叶;以Edwards Life Sciences生产的对应型号的牛心包瓣作为对照组(每个测试型号包括3个测试瓣和1个对照瓣)。在测试前对所有型号的测试瓣和对照瓣初步评估流体力学性能,在测试中期,分别在瓣叶完成5000万次、1亿次和1.5亿次循环时的时间点对瓣叶进行流体力学性能评估。在瓣叶完成2亿次循环后,对其进行最终的体外耐疲劳性能评估。在数字减影血管造影下从右侧颈静脉经导管完成介入三尖瓣的释放,在术后6个月时通过经胸超声心动图及病理解剖来检查新型介入瓣膜的体内耐久性能。结果经过2亿次疲劳试验,测试瓣叶和对照瓣叶均完好无损,能够完全开放与闭合且流体动力学性能未受影响。新型经导管三尖瓣介入瓣膜耐疲劳测试通过了《GB12279-2008心血管植入物人工心脏瓣膜》7疲劳测试的要求,且流体力学测试结果符合《GB12279-2008心血管植入物人工心脏瓣膜》6.5脉动流试验的要求。体内耐久性试验表明该介入瓣膜具有良好的开闭性能,术后6个月瓣叶无钙化,无破损。结论新型经导管三尖瓣介入瓣膜具有良好的耐久性及流体力学特性。 展开更多
关键词 三尖瓣关闭不全 介入瓣膜 耐久性试验 装置研制
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Predictive value of age,creatinine,and ejection fraction(ACEF)score for in-hospital mortality and major adverse events in patients with acute type A aortic dissection
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作者 LI Chen-xi wang qiu-ji +3 位作者 LIU Ji-tao FENG Wei-qi LI Xin FAN Rui-xin 《South China Journal of Cardiology》 CAS 2021年第4期223-230,247,共9页
Background Patients with decreased cardiac and renal function,as well as old age suffer from poor outcomes when undergoing cardiac surgery.The aim of this study was to evaluate the association of age,creatinine and ej... Background Patients with decreased cardiac and renal function,as well as old age suffer from poor outcomes when undergoing cardiac surgery.The aim of this study was to evaluate the association of age,creatinine and ejection fraction(ACEF)score with in-hospital prognosis of patients with the acute type A aortic dissection(ATAAD).Methods From September 2017 to June 2021,a total of 435 ATAAD patients undergoing open surgery repair were enrolled,and classified into low ACEF(ACEF score<0.91,n=286)and high ACEF group(ACEF score≥0.91,n=149)according to the optimal cutoff value of 0.91.Logistic regression analysis was performed to investigate the association between ACEF score with adverse events.Results Thirty-five(8.0%)patients were excluded and 94(21.6%)developed in-hospital major adverse clinical events(MACEs)during hospitalization.The in-hospital mortality in high ACEF group was significantly higher than in low ACEF group(13.4%vs.5.2%,P=0.003).The in-hospital MACE rate was also significantly higher in patients with high ACEF score(high ACEF group:27.5%vs.low ACEF group:18.5%,P=0.031).Multivariable logistic analysis revealed that ACEF score was an independent indicator for in-hospital mortality[odds ratio(OR):5.66,95%confidence interval(CI):1.43-22.48,P=0.014]and in-hospital MACEs(OR:3.44,95%CI:1.30-9.15,P=0.013).Conclusions Elevated ACEF score was an independent predictor for in-hospital mortality and MACEs in patients with ATAAD undergoing open surgery repair,which might provide additional risk stratification. 展开更多
关键词 acute type A aortic dissection ACEF score in-hospital mortality
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