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嵌合抗原受体T细胞疗法CRS/ICANS反应的ASTCT共识解读 被引量:4
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作者 傅琤琤 王如菊 吴德沛 《中国实验血液学杂志》 CAS CSCD 北大核心 2021年第6期1982-1986,共5页
嵌合抗原受体T细胞疗法被美国临床肿瘤学会评为2017年最大的研究突破,现正迅速成为治疗血液学恶性肿瘤最有前途的一项新疗法,但同时也带来了新的挑战——细胞因子释放综合征和神经毒性等,有时甚至会引起患者的死亡。在不同的多中心试验... 嵌合抗原受体T细胞疗法被美国临床肿瘤学会评为2017年最大的研究突破,现正迅速成为治疗血液学恶性肿瘤最有前途的一项新疗法,但同时也带来了新的挑战——细胞因子释放综合征和神经毒性等,有时甚至会引起患者的死亡。在不同的多中心试验报告中,以上毒性事件的发生率和严重程度也不尽相同,究其原因是对毒性的评估和分级在不同的临床试验和机构间存在很大差异。2018年发布的ASTCT共识提出了免疫效应细胞相关的细胞因子释放综合征和神经毒性的分级,本文就该共识的主要内容进行解读,以期为我国该领域相关工作的开展及安全性策略的制定提供参考。 展开更多
关键词 嵌合抗原受体 细胞因子释放综合征 神经毒性 CAR-T细胞疗法 免疫效应细胞
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Third Order Elastic Constants and Anharmonic Properties of the Zr_(41.2)Ti_(13.8)Cu_(12.5)Ni_(10.0)Be_(22.5) Bulk Metallic Glass 被引量:1
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作者 wang ru-ju LI Feng-Ying +1 位作者 QIN Zhi-Cheng wang Wei-Hua 《Chinese Physics Letters》 SCIE CAS CSCD 2001年第3期414-415,共2页
The longitudinal velocity Vl and shear velocity Vs of ultrasonic wave propagated along arbitrary three perpendicular directions of the Zr_(41.2)Ti_(13.8)Cu_(12.5)Ni_(10.0)Be_(22.5) bulk metallic glass(Zr/Ti BMG)have b... The longitudinal velocity Vl and shear velocity Vs of ultrasonic wave propagated along arbitrary three perpendicular directions of the Zr_(41.2)Ti_(13.8)Cu_(12.5)Ni_(10.0)Be_(22.5) bulk metallic glass(Zr/Ti BMG)have been measured at ambient pressure,under hydrostatic pressure(up to 0.5 GPa)and uniaxial compression(up to 70 MPa)using the pulse echo overlap method.The third order elastic constants and the Grüneisen parameter related to the anharmonic properties were derived and discussed.It was found that the BMG with marked different microstructural characteristics comparing with the amorphous carbon exhibited different behaviours related to shear vibratory under high pressure. 展开更多
关键词 ELASTIC HARMONIC HYDROSTATIC
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Pressure Induced Phase Transition in TiB 被引量:1
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作者 LI Feng-Ying CHEN Liang-Chen +4 位作者 wang Li-Jun GU Hui-Cheng wang ru-ju CHE Rong-Zheng SHEN Zhong-Yi 《Chinese Physics Letters》 SCIE CAS CSCD 2001年第9期1240-1241,共2页
In situ high pressure x-ray diffraction and electrical resistance experiments on TiB have been carried out by using a diamond anvil cell device. The results revealed that the sample undergoes a first-order phase trans... In situ high pressure x-ray diffraction and electrical resistance experiments on TiB have been carried out by using a diamond anvil cell device. The results revealed that the sample undergoes a first-order phase transition at pressures of 3.5-5.0 Gpa and 4.0-5.5 Gpa for the x-ray diffraction and electrical resistance experiments, respectively. The parameters of the state equation are calculated before and after the phase transition and compared with the values calculated by Mohn et al. [J. Phys. C: Solid State Phys. 21(1988)2829] using the augmented spherical wave method. 展开更多
关键词 RESISTANCE TRANSITION TRANSITION
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Elastic Behaviors of Bulk Metallic Glass Zr_(41.2)Ti_(13.8)Cu_(12.5)Ni_(10.0)Be_(22.5) Investigated by Using Ultrasonic Technique
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作者 wang ru-ju QIN Zhi-cheng +1 位作者 LI Feng-ying XIE Hong-sen 《Chinese Physics Letters》 SCIE CAS CSCD 1997年第12期920-923,共4页
The acoustic velocity,attenuation,and their pressure dependence of a bulk metallic glass Zr_(41.2)Ti_(13.8)Cu_(12.5)Ni_(10.0)Be_(22.5) have been measured under pressures up to 0.5 GPa at room temperature using the pul... The acoustic velocity,attenuation,and their pressure dependence of a bulk metallic glass Zr_(41.2)Ti_(13.8)Cu_(12.5)Ni_(10.0)Be_(22.5) have been measured under pressures up to 0.5 GPa at room temperature using the pulse echo overlap method.The sample was prepared from melt by quenching into liquid nitrogen.Bulk modulus,Young’s modulus,shear modulus,and Poisson’s ratio were derived,other elastic properties and vibrational anharmonicity were also discussed. 展开更多
关键词 MODULUS BULK ELASTIC
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High Pressure Raman Study of Phase Transitions on Solid Benzene Using Raman Notch Filter Set
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作者 XU Li-wen wang ru-ju CHEN Liang-chen 《Chinese Physics Letters》 SCIE CAS CSCD 1996年第4期293-296,共4页
A high-throughput Haman notch filter set has been manufactured and used to collect the Raman scattering signals of pressure-hiduced phase transitions of solid benzene in a diamond anvil cell up to 15 GPa at room tempe... A high-throughput Haman notch filter set has been manufactured and used to collect the Raman scattering signals of pressure-hiduced phase transitions of solid benzene in a diamond anvil cell up to 15 GPa at room temperature.The changes in the profiles as well as the frequencies of Raman scattering spectra are observed and enable us to determine the phase transition. 展开更多
关键词 temperature. transition. TRANSITION
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Ultrasonic Properties of the MgB_(2) Superconductor
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作者 LI Shao-Chun wang ru-ju +4 位作者 LI Feng-Ying LIU Zhen-Xing ZHU Jia-Lin YU Ri-cheng JIN Chang-Qing 《Chinese Physics Letters》 SCIE CAS CSCD 2001年第10期1369-1370,共2页
The sound velocities of longitudinal and shear waves are measured on a polycrystalline MgB_(2) superconductor with Tc of 39 K. The specimen used in the experiments is pressed and heated using the MgB_(2) powder. The e... The sound velocities of longitudinal and shear waves are measured on a polycrystalline MgB_(2) superconductor with Tc of 39 K. The specimen used in the experiments is pressed and heated using the MgB_(2) powder. The elastic moduli, Debye temperature and specific heat at room temperature are obtained based on sound velocity data. The results indicate that the velocities are much higher than those in the usual materials, while elastic constants remain reasonably soft, which may be due to the high transition temperature of the MgB2 superconductor. 展开更多
关键词 HEATED SUPERCONDUCTOR SUPERCONDUCTOR
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