Selenium supplements were not able to restore the ultrastructural changes in the myocardiurn of latent Keshan disease patients taken by using cardiac catheter endomyocardial biopsy. Observations on the changes of sele...Selenium supplements were not able to restore the ultrastructural changes in the myocardiurn of latent Keshan disease patients taken by using cardiac catheter endomyocardial biopsy. Observations on the changes of seleniurn status and the incidence of Keshan disease showed that new latent and naturally-occurring chronic cases were found in the endemic area even after selenium levels had been elevated in the residents to the levels typical in the non-endemic area. These results indicate that although selenium deficiency might be a primary pathogenetic geogen in the occurrence of Keshan disease, it is rather a conditional predisposing factor than a specific or initiative aetiologic factor for the occurrence of Keshan disease. Selenium supplmentation could apparently alleviate the higher platelet responsiveness of residents in the endemic area, which might contribute to eliminating the basis for the occurrence of the multifocal perivascular necroses in myocardium of acute and subacute Keshan disease展开更多
[目的]分析老年结直肠癌患者根治术的术后认知功能障碍(postoperative cognitive disfunction,POCD)高危因素,探讨防范措施,提升老年结直肠癌根治术患者围术期安全及预后质量。[方法]选择行结直肠癌根治术的老年患者228例为研究对象。术...[目的]分析老年结直肠癌患者根治术的术后认知功能障碍(postoperative cognitive disfunction,POCD)高危因素,探讨防范措施,提升老年结直肠癌根治术患者围术期安全及预后质量。[方法]选择行结直肠癌根治术的老年患者228例为研究对象。术后2 d采用MMSE评分(2 d MMSE评分)对患者进行认知功能测评,较术前2 d MMSE评分下降2分为POCD者(观察组,57例),其他为认知功能正常者(对照组,171例)。收集整理2组患者个体资料及临床资料行组间比较,组间比较有差异的指标纳入多因素Logistic行高危因素分析。[结果](1)单因素分析显示,年龄、受教育时间、合并疾病、术前ASA分级、舒芬太尼用量、术中显著低氧血症、术中显著低血压、术中输血量、术后SIRS评分、术后是否符合入住ICU指征与POCD发生相关;(2)多因素Logistic分析显示,合并糖尿病、合并高血压、术中显著低氧血症、术中显著低血压、术后SIRS评分≥3分、术后符合入住ICU指征为发生POCD的高危因素。[结论]老年结直肠癌患者麻醉根治术发生POCD的高危因素以患者个体特征及术中关键指标的控制为主,术中应严密监测患者血压、血氧等关键指标,降低对患者中枢神经的刺激,降低发生POCD概率,以期提升患者术后及远期生存质量。展开更多
文摘Selenium supplements were not able to restore the ultrastructural changes in the myocardiurn of latent Keshan disease patients taken by using cardiac catheter endomyocardial biopsy. Observations on the changes of seleniurn status and the incidence of Keshan disease showed that new latent and naturally-occurring chronic cases were found in the endemic area even after selenium levels had been elevated in the residents to the levels typical in the non-endemic area. These results indicate that although selenium deficiency might be a primary pathogenetic geogen in the occurrence of Keshan disease, it is rather a conditional predisposing factor than a specific or initiative aetiologic factor for the occurrence of Keshan disease. Selenium supplmentation could apparently alleviate the higher platelet responsiveness of residents in the endemic area, which might contribute to eliminating the basis for the occurrence of the multifocal perivascular necroses in myocardium of acute and subacute Keshan disease
文摘[目的]分析老年结直肠癌患者根治术的术后认知功能障碍(postoperative cognitive disfunction,POCD)高危因素,探讨防范措施,提升老年结直肠癌根治术患者围术期安全及预后质量。[方法]选择行结直肠癌根治术的老年患者228例为研究对象。术后2 d采用MMSE评分(2 d MMSE评分)对患者进行认知功能测评,较术前2 d MMSE评分下降2分为POCD者(观察组,57例),其他为认知功能正常者(对照组,171例)。收集整理2组患者个体资料及临床资料行组间比较,组间比较有差异的指标纳入多因素Logistic行高危因素分析。[结果](1)单因素分析显示,年龄、受教育时间、合并疾病、术前ASA分级、舒芬太尼用量、术中显著低氧血症、术中显著低血压、术中输血量、术后SIRS评分、术后是否符合入住ICU指征与POCD发生相关;(2)多因素Logistic分析显示,合并糖尿病、合并高血压、术中显著低氧血症、术中显著低血压、术后SIRS评分≥3分、术后符合入住ICU指征为发生POCD的高危因素。[结论]老年结直肠癌患者麻醉根治术发生POCD的高危因素以患者个体特征及术中关键指标的控制为主,术中应严密监测患者血压、血氧等关键指标,降低对患者中枢神经的刺激,降低发生POCD概率,以期提升患者术后及远期生存质量。
