目的探讨密骨颗粒联合阿仑膦酸钠维D3片治疗骨质疏松症的临床疗效与安全性。方法随机将受试者分为试验组(n=109)和对照组(n=75),试验组给予密骨颗粒联合阿仑膦酸钠维D3片,对照组给予阿仑膦酸钠维D3片,疗程为12个月。分别于治疗前、治疗...目的探讨密骨颗粒联合阿仑膦酸钠维D3片治疗骨质疏松症的临床疗效与安全性。方法随机将受试者分为试验组(n=109)和对照组(n=75),试验组给予密骨颗粒联合阿仑膦酸钠维D3片,对照组给予阿仑膦酸钠维D3片,疗程为12个月。分别于治疗前、治疗后6、12个月时行骨代谢、骨密度(bone mineral density,BMD)、血常规、肝肾功能等检查,并记录VAS与SF-36评分,观察受试者的不良反应。结果①12个月后,试验组和对照组受试者的腰椎BMD分别增加3.70%和4.18%,两组间比较差异无统计学意义(P>0.05);髋部BMD分别下降0.89%和17.02%,对照组下降更明显(P<0.05);②12个月,试验组和对照组受试者的PTH分别增加44.29%和72.03%,25(OH)D分别下降11.83%和9.29%,β-CTX分别下降32.25%和20.0%,PINP分别下降36.70%和58.95%,BGP分别下降22.82%和27.24%,ALP分别下降20.43%和25.97%,两组间比较差异有统计学意义(P<0.05);③两组受试者治疗后腰痛VAS评分均下降(P<0.05),组间比较差异有统计学意义(P<0.05)。治疗9、12个月后试验组SF-36PCS及MCS功能评分高于对照组,比较差异有统计学意义(P<0.05);④两组均未出现严重不良反应。结论密骨颗粒联合阿仑膦酸钠维D3片治疗骨质疏松症可以降低骨转换速度,同时还可以促进成骨,提升腰部骨密度,保持髋部骨密度,降低骨流失,降低患者躯体疼痛,改善生活质量。未出现不良反应与肝肾功能损害,具有较好的安全性。展开更多
In the area of secure Web information system, mutual authentication and key agreement are essential between Web clients and servers. An efficient certificateless authenticated key agreement protocol for Web client/ser...In the area of secure Web information system, mutual authentication and key agreement are essential between Web clients and servers. An efficient certificateless authenticated key agreement protocol for Web client/server setting is proposed, which uses pairings on certain elliptic curves. We show that the newly proposed key agreement protocol is practical and of great efficiency, meanwhile, it satisfies every desired security require ments for key agreement protocols.展开更多
The certificateless authenticated key agreement protocol proposed by Mandt et al does not haVE the property of key-compromise impersonation （K-CI） resilience. An improved protocol with a simple modification of their...The certificateless authenticated key agreement protocol proposed by Mandt et al does not haVE the property of key-compromise impersonation （K-CI） resilience. An improved protocol with a simple modification of their protocol is proposed in this paper. In particular, our improved protocol is proved to be immune to the K-CI attack and at the same time possess other security properties.展开更多
文摘目的探讨密骨颗粒联合阿仑膦酸钠维D3片治疗骨质疏松症的临床疗效与安全性。方法随机将受试者分为试验组(n=109)和对照组(n=75),试验组给予密骨颗粒联合阿仑膦酸钠维D3片,对照组给予阿仑膦酸钠维D3片,疗程为12个月。分别于治疗前、治疗后6、12个月时行骨代谢、骨密度(bone mineral density,BMD)、血常规、肝肾功能等检查,并记录VAS与SF-36评分,观察受试者的不良反应。结果①12个月后,试验组和对照组受试者的腰椎BMD分别增加3.70%和4.18%,两组间比较差异无统计学意义(P>0.05);髋部BMD分别下降0.89%和17.02%,对照组下降更明显(P<0.05);②12个月,试验组和对照组受试者的PTH分别增加44.29%和72.03%,25(OH)D分别下降11.83%和9.29%,β-CTX分别下降32.25%和20.0%,PINP分别下降36.70%和58.95%,BGP分别下降22.82%和27.24%,ALP分别下降20.43%和25.97%,两组间比较差异有统计学意义(P<0.05);③两组受试者治疗后腰痛VAS评分均下降(P<0.05),组间比较差异有统计学意义(P<0.05)。治疗9、12个月后试验组SF-36PCS及MCS功能评分高于对照组,比较差异有统计学意义(P<0.05);④两组均未出现严重不良反应。结论密骨颗粒联合阿仑膦酸钠维D3片治疗骨质疏松症可以降低骨转换速度,同时还可以促进成骨,提升腰部骨密度,保持髋部骨密度,降低骨流失,降低患者躯体疼痛,改善生活质量。未出现不良反应与肝肾功能损害,具有较好的安全性。
基金Supported bythe National Natural Science Foundationof China (60225007 ,60572155) the Science and Technology ResearchProject of Shanghai (04DZ07067)
文摘In the area of secure Web information system, mutual authentication and key agreement are essential between Web clients and servers. An efficient certificateless authenticated key agreement protocol for Web client/server setting is proposed, which uses pairings on certain elliptic curves. We show that the newly proposed key agreement protocol is practical and of great efficiency, meanwhile, it satisfies every desired security require ments for key agreement protocols.
基金the National Natural Science Foundation of China (60773086)
文摘The certificateless authenticated key agreement protocol proposed by Mandt et al does not haVE the property of key-compromise impersonation （K-CI） resilience. An improved protocol with a simple modification of their protocol is proposed in this paper. In particular, our improved protocol is proved to be immune to the K-CI attack and at the same time possess other security properties.
