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急性心力衰竭患者使用左西孟旦治疗的效果及安全性观察
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作者 郭振 王涛丽 李乃杰 《国际医药卫生导报》 2024年第12期2039-2043,共5页
目的本研究旨在评估左西孟旦治疗急性心力衰竭(AHF)患者的应用效果。方法选取2021年1月至2023年10月期间铜川市人民医院收治的98例AHF患者,根据受试者进入研究的时间顺序随机分为对照组(49例)和观察组(49例)。对照组男27例,女22例;年龄(... 目的本研究旨在评估左西孟旦治疗急性心力衰竭(AHF)患者的应用效果。方法选取2021年1月至2023年10月期间铜川市人民医院收治的98例AHF患者,根据受试者进入研究的时间顺序随机分为对照组(49例)和观察组(49例)。对照组男27例,女22例;年龄(67.14±6.65)岁;美国纽约心脏病协会(NYHA)分级:Ⅱ级20例,Ⅲ级15例,Ⅳ级14例;采用常规方案治疗。观察组男28例,女21例;年龄(66.57±6.64)岁;NYHA分级:Ⅱ级19例,Ⅲ级16例,Ⅳ级14例;采用常规方案加左西孟旦(静脉注射)治疗。两组均治疗4周。比较两组患者治疗前和治疗后临床症状(胸闷及呼吸困难)持续时间、心肌酶水平[髓过氧化物酶(MPO)、N末端脑钠肽前体(NT-proBNP)、心肌肌钙蛋白I(cTnI)及基质金属蛋白酶9(MMP-9)]、心功能指标[左心室内径(LVD)、左心房内径(LAD)、左心室短轴缩短率(LVFS)、三尖瓣环收缩期位移(TAPSE)、心率(HR)]及治疗期间不良反应的发生情况。采用独立样本t检验和χ^(2)检验。结果治疗后,观察组胸闷[(1.82±0.37)min/次]、呼吸困难[(1.68±0.39)min/次]持续时间均短于对照组[(2.49±0.42)min/次、(2.59±0.41)min/次],差异均有统计学意义(均P<0.05);观察组MPO[(2.89±0.61)pg/L]、NT-proBNP[(2.05±0.67)g/L]、cTnI[(2.58±0.56)μg/L]、MMP-9[(58.58±7.41)μg/L]水平均低于对照组[(4.36±0.83)pg/L、(4.69±1.54)g/L、(2.97±0.63)μg/L、(90.64±8.84)μg/L],差异均有统计学意义(均P<0.05);观察组LVD[(40.44±4.84)mm]和LVFS[(31.41±2.54)%]均高于对照组[(32.65±4.64)mm、(22.63±3.68)%],LAD[(29.89±3.38)mm]、TAPSE[(15.85±3.03)mm]和HR[(69.85±8.23)次/min]均低对照组[(37.65±4.65)mm、(17.59±3.13)mm、(86.52±8.51)次/min],差异均有统计学意义(均P<0.05)。治疗期间两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论左西孟旦在治疗AHF患者中显示出良好的效果和安全性,可作为该病症的有效治疗选择。 展开更多
关键词 急性心力衰竭 左西孟旦 心肌酶 心功能 安全性
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Hydrological changes and settlement migrations in the Keriya River delta in central Tarim Basin ca. 2.7–1.6 ka BP: Inferred from ^(14)C and OSL chronology 被引量:6
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作者 ZHANG Feng wang taoi +4 位作者 Hamid . YIMIT SHI QingDong RUAN QiuRong SUN ZhiQiong LI Fang 《Science China Earth Sciences》 SCIE EI CAS 2011年第12期1971-1980,共10页
Over one hundred artifacts, including shards, chopped wood, bronze and iron ware debris as well as footprints, have been discovered during archaeological investigations at and around the central Taklamakan Desert Yuan... Over one hundred artifacts, including shards, chopped wood, bronze and iron ware debris as well as footprints, have been discovered during archaeological investigations at and around the central Taklamakan Desert Yuansha Site (38°52′N, 81°35′E). Dating (14C and OSL) and landform study show that the present-day dry Keriya River once sustained an oasis human settle- ment in 2.6 ka BP, historically falling into the Spring and Autumn Period (716-475 BCE) of Chinese history. The chronology and archaeological interpretations also show that some 400 years later, the local Keriya River channel had shifted 40 km southeast to sustain a Western Han (206 BCE-25 CE) Wumi settlement at the Karadun site. In the meantime, river-channel migration had allowed reoccupation of a site west of Yuansha City around 1.9 ka BP (abandoned again by 1.6 ka BP). The remains' chronology shows that this site was affiliated to Wumi culture and Eastern Han (24-220 CE) dynasty rule. Palaeoclimatic records indicate that the migrations of the river and oasis settlers between 2.7 and 1.6 ka BP were coeval with Central Asian climate changes. Yuansha City was built just after the end of 2.8 ka BP glacier advances in western China, suggesting that release of more water during the subsequent glacier recession may have facilitated oasis development such that Iron Age European peoples could settle in the Tarim Basin. As shown from analysis of archeological remains, not only at Yuansha but also in other ancient cities in the Tarim such as Loulan and Jingjue (Niya), conditions around 1.6 ka BP were dry enough to cause oasis decline. Thus, the results reported here enhance our knowledge about environmental changes and their effects on human activities and cultural evolution in western China and will stimulate further interdisciplinary studies of landscape and oasis history in the Tarim Basin. 展开更多
关键词 塔里木盆地 克里雅河 水文变化 年代学 14C BP 迁移 三角洲
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