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雷根平自拟芪地固肾方治疗特发性膜性肾病经验 被引量:1
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作者 李鑫 王旭钊 +2 位作者 王婷 董盛 雷根平(指导) 《山东中医杂志》 2023年第6期618-621,645,共5页
雷根平教授认为特发性膜性肾病的病因病机当分虚实,虚证病机在于肾精亏损、脾气虚弱,实证病机在于风、水、湿、热、瘀;以虚为本,以实为标,虚实病机贯穿于本病始终,并每因外邪而诱发加重。针对此病因病机,采用“培、补、固、清、宣、通... 雷根平教授认为特发性膜性肾病的病因病机当分虚实,虚证病机在于肾精亏损、脾气虚弱,实证病机在于风、水、湿、热、瘀;以虚为本,以实为标,虚实病机贯穿于本病始终,并每因外邪而诱发加重。针对此病因病机,采用“培、补、固、清、宣、通”六法并行的治疗总则,自拟芪地固肾方治疗此病。附医案一则。 展开更多
关键词 特发性膜性肾病 虚实相因 肾精亏损 脾气虚弱 芪地固肾方 雷根平
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基于“火热论”及“火郁发之”理论探讨冠脉介入术后心绞痛证治思路
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作者 尚雨 王宇婷 +11 位作者 赵明君 王旭钊 吴杰 徐超 任耀龙 宋发亮 王丽蓉 胡子恒 王奕祺 刘东敏 童存存 王群让 《中国中医急症》 2023年第12期2119-2121,2130,共4页
冠脉介入术后心绞痛具有极高的发病率,是目前临床亟须解决的难题。根据冠脉介入术后心绞痛发病时的临床症状将其归属于中医学“胸痹”范畴。文章以刘完素的“火热论”为基点并结合“火郁发之”理论,认为外感邪火是致病的重要因素、内生... 冠脉介入术后心绞痛具有极高的发病率,是目前临床亟须解决的难题。根据冠脉介入术后心绞痛发病时的临床症状将其归属于中医学“胸痹”范畴。文章以刘完素的“火热论”为基点并结合“火郁发之”理论,认为外感邪火是致病的重要因素、内生火热是发病的根本原因,总结出郁热之火、瘀热之火、阴虚内火、热毒之火、湿热之火均为冠脉介入术后心绞痛发病的重要病机,基于此化生出调、清、利、化、导五法以发郁热、泻实火、利湿热、化瘀热、导虚热等大法,为临床辨治本病提供新的思路。 展开更多
关键词 冠脉介入术后心绞痛 火热论 火郁发之
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Slope Debris Flows in the Wenchuan Earthquake Area 被引量:13
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作者 LI Yanfu wang Zhaoyin +1 位作者 SHI Wenjing wang xuzhao 《Journal of Mountain Science》 SCIE CSCD 2010年第3期226-233,共8页
Avalanches and landslides,induced by the Wenchuan Earthquake on May 12,2008,resulted in a lot of disaggregated,solid material on slopes that could be readily mobilized as source material for debris flows.Rainstorms tr... Avalanches and landslides,induced by the Wenchuan Earthquake on May 12,2008,resulted in a lot of disaggregated,solid material on slopes that could be readily mobilized as source material for debris flows.Rainstorms triggered numerous slope debris flows with great damage to highways and rivers over the subsequent two years.Slope debris flows(as opposed to channelized debris flows) are defined as phenomena in which high-concentration mixtures of debris and water flow down slopes for short distances to highways and river banks.Based on field investigations and measurements of 19 slope debris flows,their main characteristics and potential mitigation strategies were studied.High rainfall intensity is the main triggering factor.Critical rainfall intensities for simultaneous occurrence of single,several and numerous slope debris flow events were 20 mm/day,30mm/day,and 90 mm/day,respectively.Field investigations also revealed that slope debris flows consist of high concentrations of cobbles,boulders and gravel.They are two-phase debris flows.The liquid phase plays the role of lubrication instead of transporting medium.Solid particles collide with each other and consume a lot of energy.The velocities of slope debris flows are very low,and their transport distances are only several tens of meters.Slope debris flows may be controlled by construction of drainage systems and by reforestation. 展开更多
关键词 Slope debris flow rainfall intensity Wenchuan Earthquake LANDSLIDE AVALANCHE
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基于COWA-G1的城市公交企业安全文化建设评价研究
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作者 王旭昭 何长峥 孙正瑶 《城市公共交通》 2022年第9期36-40,共5页
公交承载着城市传承发展的脉络,安全文化是实现城市公交企业安全发展的“根”和“魂”,推进安全文化建设,是汇集参与支持安全生产工作力量、实施安全发展战略的必然要求。本文通过北京公交集团安全文化建设实践,从安全理念文化、安全管... 公交承载着城市传承发展的脉络,安全文化是实现城市公交企业安全发展的“根”和“魂”,推进安全文化建设,是汇集参与支持安全生产工作力量、实施安全发展战略的必然要求。本文通过北京公交集团安全文化建设实践,从安全理念文化、安全管理文化、安全物质文化三个方面构建城市公交企业安全文化建设评价体系,并运用COWA-G1算法进行评价,确定各项指标权重,为城市公交企业安全文化建设发展提供可借鉴的评价体系。 展开更多
关键词 安全文化 城市公交 安全管理 COWA-G1模型
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基于核因子E2相关因子2/血红素加氧酶-1信号通路探讨益气康肺方对脂多糖感染急性肺损伤地鼠氧化损伤的影响
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作者 赵秋娟 雷根平 +3 位作者 冯喆 王旭钊 何旭恺 张玲 《环球中医药》 CAS 2024年第9期1724-1730,共7页
目的基于核因子E2相关因子2/血红素加氧酶-1(nuclear factor erythroid-2-related factor 2/heme oxygenase 1,Nrf2/HO-1)信号通路探讨益气康肺方对脂多糖(lipopolysaccharide,LPS)感染的金黄地鼠肺氧化损伤的影响及其作用机制。方法将6... 目的基于核因子E2相关因子2/血红素加氧酶-1(nuclear factor erythroid-2-related factor 2/heme oxygenase 1,Nrf2/HO-1)信号通路探讨益气康肺方对脂多糖(lipopolysaccharide,LPS)感染的金黄地鼠肺氧化损伤的影响及其作用机制。方法将60只SPF级叙利亚金黄地鼠,随机分为空白组、模型组、地塞米松组、益气康肺方低剂量组、益气康肺方中剂量组、益气康肺方高剂量组,每组雌性5只,雄性5只。造模开始前予以预防性给药,空白组和模型组予以等量生理盐水灌胃,地塞米松组于造模前连续腹腔注射地塞米松磷酸钠注射液4天,益气康肺方低、中、高剂量组于造模前连续灌胃给予相应剂量中药混悬液14天。预防性给药结束后第2天,开始LPS气管滴注建立急性肺损伤(acute lung injury,ALI)地鼠模型,造模结束48小时后解剖取材。BCA法检测肺泡灌洗液蛋白含量水平并计算地鼠肺指数;HE染色检测肺组织病理改变;荧光探针检测活性氧(reactive oxygen species,ROS)含量;TBA法检测丙二醛(malondialdehyde,MDA)含量;WST-1法检测肺组织超氧化物歧化酶(superoxide dismutase,SOD)活力,比色法检测谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-PX)活力;Western blot法检测肺组织Nrf2、HO-1蛋白表达水平。结果与空白组比较,模型组肺指数及BALF中蛋白浓度升高,肺组织病理损伤严重,ROS及MDA水平升高,SOD和GSH-PX活力较低,Nrf2、HO-1蛋白含量较低。药物干预处理后,与模型组比较,地塞米松和各中药组肺指数及BALF中蛋白浓度较低,肺组织病理损伤轻,ROS及MDA水平低,SOD和GSH-PX活力高,Nrf2、HO-1蛋白含量高,尤以益气康肺方高剂量组疗效最为显著(P<0.05)。结论益气康肺方可能是通过激活Nrf2/HO-1通路,增强SOD、GSH-PX的活力,抑制LPS引起的炎症和氧化损伤。 展开更多
关键词 急性肺损伤 益气康肺方 氧化应激 炎症 核因子E2相关因子2/血红素加氧酶-1信号通路 脂多糖
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Sediment storage and morphology of the Yalu Tsangpo valley due to uneven uplift of the Himalaya 被引量:5
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作者 wang ZhaoYin YU Guo An +2 位作者 wang xuzhao Charles S. MELCHING LIU Le 《Science China Earth Sciences》 SCIE EI CAS CSCD 2015年第8期1440-1445,共6页
The fluvial process of the Yalu Tsangpo River occurs concurrently with the uplift of the Qinghai-Tibet Plateau.Therefore,the river exhibits unique features in morphology and sediment deposition.Field investigations we... The fluvial process of the Yalu Tsangpo River occurs concurrently with the uplift of the Qinghai-Tibet Plateau.Therefore,the river exhibits unique features in morphology and sediment deposition.Field investigations were performed from 2009–2011and the depth of the interface between the sediment deposits and bed rock was detected with an electromagnetic imaging system(EH4)at 29 cross sections.Sediment deposits were sampled along the Yalu Tsangpo valley from Xietongmen to the Yalu Tsangpo Canyon.The results show that a huge amount of sediment has been deposited in four wide valley sections because the uplift rate in these sections was lower than that in the downstream gorge sections over the past million years.About 518 billion m3of gravel and sand have been stored in the high mountain river valleys,which has changed the V-shaped mountain river valley into a U-shaped wide river valley in the four sections.In the sections with high uplift rates the river bed is incised and has formed gorges and the Yalu Tsangpo Canyon. 展开更多
关键词 Yalu Tsangpo River sediment deposits uneven uplift HIMALAYA wide valley
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