由于多种电力电子设备均以三相PWM变流器结构为基础,据此论文在分析当前电力电子实验功能需求的基础上,结合多种电力电子实验拓扑结构及控制方式的联系与区别,分析电力电子通用实验平台的功能需求,对其总体结构和主电路进行设计。论文...由于多种电力电子设备均以三相PWM变流器结构为基础,据此论文在分析当前电力电子实验功能需求的基础上,结合多种电力电子实验拓扑结构及控制方式的联系与区别,分析电力电子通用实验平台的功能需求,对其总体结构和主电路进行设计。论文着重阐述了基于PWM变流器实验平台实现单相APF(Active Power Filter,有源电力滤波器)和三相APF补偿实验拓扑结构的转换原理和实现过程,最后就电气化铁道有源综合补偿系统实验、电力机车交流传动系统实验的转换原理进行了可行性描述。展开更多
Background Cyclosporin A （CsA） is a substrate of both cytochrome P450 3A （CYP3A） and P-glycoprotein （P-gp）, some of the single nucleotide polymorphisms （SNPs） in these genes are associated with interindividual...Background Cyclosporin A （CsA） is a substrate of both cytochrome P450 3A （CYP3A） and P-glycoprotein （P-gp）, some of the single nucleotide polymorphisms （SNPs） in these genes are associated with interindividual variations in CsA pharmacokinetics. We studied the influence of these SNPs on the incidence of rejection and CsA nephrotoxicity, as well as pneumonia within one year after renal transplant and post-transplantation diabetes mellitus （PTDM）, in order to find whether genetic evaluation may help to identify patients at risk and to modulate CsA therapy to optimize graft and patient outcomes. Methods A total of 208 renal transplant recipients receiving CsA were genotyped for ABCB1 （C1236T, G2677T/A, and C3435T）, CYP3A4＊IG, and CYP3A5＊3 by direct sequencing method. Retrospective case control study was utilized to identify the association between CYP3A4＊IG, CYP3A5＊3, ABCB1 genetic polymorphisms and CsA-related outcomes. Results The patients with a CYP3A4＊1G/＊1G genotype were found to have a higher incidence of acute rejection compared with those with CYP3A4＊1/＊1. Conclusion CYP3A4＊1G/＊1G genotype predict increased risk of acute rejection, so genetic evaluation may partly help to identify patients at risk and to modulate CsA therapy to optimize graft and patient outcomes.展开更多
文摘由于多种电力电子设备均以三相PWM变流器结构为基础,据此论文在分析当前电力电子实验功能需求的基础上,结合多种电力电子实验拓扑结构及控制方式的联系与区别,分析电力电子通用实验平台的功能需求,对其总体结构和主电路进行设计。论文着重阐述了基于PWM变流器实验平台实现单相APF(Active Power Filter,有源电力滤波器)和三相APF补偿实验拓扑结构的转换原理和实现过程,最后就电气化铁道有源综合补偿系统实验、电力机车交流传动系统实验的转换原理进行了可行性描述。
文摘Background Cyclosporin A （CsA） is a substrate of both cytochrome P450 3A （CYP3A） and P-glycoprotein （P-gp）, some of the single nucleotide polymorphisms （SNPs） in these genes are associated with interindividual variations in CsA pharmacokinetics. We studied the influence of these SNPs on the incidence of rejection and CsA nephrotoxicity, as well as pneumonia within one year after renal transplant and post-transplantation diabetes mellitus （PTDM）, in order to find whether genetic evaluation may help to identify patients at risk and to modulate CsA therapy to optimize graft and patient outcomes. Methods A total of 208 renal transplant recipients receiving CsA were genotyped for ABCB1 （C1236T, G2677T/A, and C3435T）, CYP3A4＊IG, and CYP3A5＊3 by direct sequencing method. Retrospective case control study was utilized to identify the association between CYP3A4＊IG, CYP3A5＊3, ABCB1 genetic polymorphisms and CsA-related outcomes. Results The patients with a CYP3A4＊1G/＊1G genotype were found to have a higher incidence of acute rejection compared with those with CYP3A4＊1/＊1. Conclusion CYP3A4＊1G/＊1G genotype predict increased risk of acute rejection, so genetic evaluation may partly help to identify patients at risk and to modulate CsA therapy to optimize graft and patient outcomes.
