为了深入研究毛细管墙体的热工特性,在非稳态传热热阻热容RC(resistance and capacity)简化模型的基础上,建立了毛细管墙体的稳态换热量分配比例模型,获得了毛细管与室内和室外换热量的比值。通过实验采集了室内外空气温度、毛细管墙体...为了深入研究毛细管墙体的热工特性,在非稳态传热热阻热容RC(resistance and capacity)简化模型的基础上,建立了毛细管墙体的稳态换热量分配比例模型,获得了毛细管与室内和室外换热量的比值。通过实验采集了室内外空气温度、毛细管墙体内壁面温度、毛细管层温度及毛细管与室内外交换的热流密度等实验数据,研究了冬季工况下毛细管墙体与室内外换热量的特点,分析了毛细管墙体的一维换热过程,并验证了毛细管墙体换热量分配比例模型的合理性。实验结果表明:毛细管辐射空调系统具有良好的稳定性,室内温度的波动较小;随着系统运行时间的增加,所建模型的计算值与实测结果更加趋于一致。该稳态换热量分配比例模型可应用于毛细管墙体热工特性评估,并可为进一步研究毛细管辐射空调系统室内负荷的计算提供理论依据。展开更多
Photothermal therapy is a direct and non-invasive therapeutic strategy.Herein,we report a general strategy for the construction of polyaniline-coated DNA nanoparticles for efficient photothermal therapy.In our design,...Photothermal therapy is a direct and non-invasive therapeutic strategy.Herein,we report a general strategy for the construction of polyaniline-coated DNA nanoparticles for efficient photothermal therapy.In our design,two G4/hemin-based DNAzymes are precisely organized in a DNA template to mimic the function of horseradish peroxidase(HRP)for the catalytic oxidation of aniline.After polymerization,the polyaniline-coated DNA nanoparticles(PANI/DNA NPs)can be efficiently obtained as the photothermal agent to elicit a pronounced photothermal effect.After cellular uptake,the noticeable photothermal effect from 808 nm laser irradiation can achieve an efficient proliferation inhibition of tumor cells.This rationally developed photothermal agent based on DNA template-assisted polymerization presents a new avenue for the development of photothermal therapy.展开更多
Nucleic acid nanostructures with structural programmability, spatial addressability and excellent biocompatibility have drawn much attention in various biomedical applications, such as bioimaging, biosensing and drug ...Nucleic acid nanostructures with structural programmability, spatial addressability and excellent biocompatibility have drawn much attention in various biomedical applications, such as bioimaging, biosensing and drug delivery. In this review, we summarize the recent research progress in the field of bioimaging based on nucleic acid nanostructures with different imaging models, including fluorescent imaging(FI), magnetic resonance imaging(MRI), photoacoustic imaging(PAI) and positron emission tomography/computed tomography(PET/CT) imaging. We also discuss the remaining challenges and further opportunities involved in the bioimaging research based on nucleic acid nanostructures.展开更多
文摘为了深入研究毛细管墙体的热工特性,在非稳态传热热阻热容RC(resistance and capacity)简化模型的基础上,建立了毛细管墙体的稳态换热量分配比例模型,获得了毛细管与室内和室外换热量的比值。通过实验采集了室内外空气温度、毛细管墙体内壁面温度、毛细管层温度及毛细管与室内外交换的热流密度等实验数据,研究了冬季工况下毛细管墙体与室内外换热量的特点,分析了毛细管墙体的一维换热过程,并验证了毛细管墙体换热量分配比例模型的合理性。实验结果表明:毛细管辐射空调系统具有良好的稳定性,室内温度的波动较小;随着系统运行时间的增加,所建模型的计算值与实测结果更加趋于一致。该稳态换热量分配比例模型可应用于毛细管墙体热工特性评估,并可为进一步研究毛细管辐射空调系统室内负荷的计算提供理论依据。
基金supported by the National Key R&D Program of China(Nos.2021YFA1200302,2018YFA0208900)the National Natural Science Foundation of China(Nos.22025201,22077023,21721002)+2 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000)the CAS Project for Young Scientists in Basic Research(No.YSBR-036)the CAS Interdisciplinary Innovation Team,Youth Innovation Promotion Association CAS,and K.C.Wong Education Foundation(No.GJTD-2018-03).
文摘Photothermal therapy is a direct and non-invasive therapeutic strategy.Herein,we report a general strategy for the construction of polyaniline-coated DNA nanoparticles for efficient photothermal therapy.In our design,two G4/hemin-based DNAzymes are precisely organized in a DNA template to mimic the function of horseradish peroxidase(HRP)for the catalytic oxidation of aniline.After polymerization,the polyaniline-coated DNA nanoparticles(PANI/DNA NPs)can be efficiently obtained as the photothermal agent to elicit a pronounced photothermal effect.After cellular uptake,the noticeable photothermal effect from 808 nm laser irradiation can achieve an efficient proliferation inhibition of tumor cells.This rationally developed photothermal agent based on DNA template-assisted polymerization presents a new avenue for the development of photothermal therapy.
基金This work was supported by the National Natural Science Foundation of China(Nos.22025201,22077023 and 21721002)the National Basic Research Program of China(Nos.2016YFA0201601 and 2018YFA0208900)+3 种基金the Fund of the Beijing Municipal Science&Technology Commission,China(No.Z191100004819008)the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000)the Key Research Program of Frontier Sciences of CAS(No.QYZDB-SSW-SLH029)the CAS Interdisciplinary Innovation Team,Youth Innovation Promotion Association CAS and K.C.Wong Education Foundation(No.GJTD-2018-03).
文摘Nucleic acid nanostructures with structural programmability, spatial addressability and excellent biocompatibility have drawn much attention in various biomedical applications, such as bioimaging, biosensing and drug delivery. In this review, we summarize the recent research progress in the field of bioimaging based on nucleic acid nanostructures with different imaging models, including fluorescent imaging(FI), magnetic resonance imaging(MRI), photoacoustic imaging(PAI) and positron emission tomography/computed tomography(PET/CT) imaging. We also discuss the remaining challenges and further opportunities involved in the bioimaging research based on nucleic acid nanostructures.
