Objective:To investigate the therapeutic efficacy and underlying mechanisms of LiZhong Tang in the context of non-alcoholic fatty liver disease(NAFLD).Methods:High-fat feed was used to induce NAFLD in rats,Blood and l...Objective:To investigate the therapeutic efficacy and underlying mechanisms of LiZhong Tang in the context of non-alcoholic fatty liver disease(NAFLD).Methods:High-fat feed was used to induce NAFLD in rats,Blood and liver samples were collected to facilitate a comparative analysis of rat body mass and liver wet weight and calculate the liver index.Liver pathology was observed,while serum transaminase and blood lipid levels were measured.The protein expression levels of PINK1,Parkin,and LC-3II in rat liver were detected using Western Blot analysis.Results:Compared with the control group,the NAFLD rats exhibited a significant increase in body weight,liver wet weight,liver index,transaminase levels,and blood lipid levels.The expression levels of PINK1,Parkin,and LC3-II protein were significantly decreased(P<0.01).Following intervention with Lizhong Tang,rats in each herbal treatment group displayed a decrease in body weight,liver wet weight,liver index,se-rum transaminase,and blood lipid levels.The expression levels of PINK1,Parkin,and LC-3II rebounded(P<0.05),with the high-dose group demonstrating the most pronounced effects(P<0.01).Histopathological examination of liver tissue revealed that rats in the model group displayed disrupted hepatic lobule structure,swollen hepatocytes,disordered arrangement,and a multi-tude of varying-sized lipid vacuoles within the cytoplasm.Conversely,rats treated with different doses of the herbal remedy exhibited improvements in liver tissue pathology,with the high-dose group showing the most notable enhancement.Conclusion:Lizhong Tang can improve NAFLD disease by regulating mitochondrial autophagy.展开更多
为获取气固两相流浓度与超声波能量衰减关系,分析了超声波衰减原理与气固两相流流体模型,搭建了气固两相流超声波测量试验平台,利用重力输送试验装置产生气固两相流流体,在超声波换能器之间距离为0.2 m,采用频率为50 k Hz换能器进行测...为获取气固两相流浓度与超声波能量衰减关系,分析了超声波衰减原理与气固两相流流体模型,搭建了气固两相流超声波测量试验平台,利用重力输送试验装置产生气固两相流流体,在超声波换能器之间距离为0.2 m,采用频率为50 k Hz换能器进行测量试验;分析处理大量试验数据,拟合出一定距离下超声波衰减情况与气固两相流体浓度变化的近似映射函数,并通过区间估计表征测量数据置信度区间。试验发现,在超声波发射接收距离一定、发射频率一定时,气固两相流体浓度越大,超声波衰减信号也越大。验证了采用超声波测量技术方法对于气固两项流浓度相关参数的检测是可行有效的。展开更多
基金Youth Fund of Guangxi Natural Science Foundat ion (No.2020GXNSFBA297133)Guangxi Traditional Chinese Medicine Administration Science and Technology Project (No.GZSY20-60)+1 种基金Natural Science Youth Fund of Guangxi University of Traditional Chinese Medicine (No.2020QN020)Guangxi Qihuang Scholar Training Project.
文摘Objective:To investigate the therapeutic efficacy and underlying mechanisms of LiZhong Tang in the context of non-alcoholic fatty liver disease(NAFLD).Methods:High-fat feed was used to induce NAFLD in rats,Blood and liver samples were collected to facilitate a comparative analysis of rat body mass and liver wet weight and calculate the liver index.Liver pathology was observed,while serum transaminase and blood lipid levels were measured.The protein expression levels of PINK1,Parkin,and LC-3II in rat liver were detected using Western Blot analysis.Results:Compared with the control group,the NAFLD rats exhibited a significant increase in body weight,liver wet weight,liver index,transaminase levels,and blood lipid levels.The expression levels of PINK1,Parkin,and LC3-II protein were significantly decreased(P<0.01).Following intervention with Lizhong Tang,rats in each herbal treatment group displayed a decrease in body weight,liver wet weight,liver index,se-rum transaminase,and blood lipid levels.The expression levels of PINK1,Parkin,and LC-3II rebounded(P<0.05),with the high-dose group demonstrating the most pronounced effects(P<0.01).Histopathological examination of liver tissue revealed that rats in the model group displayed disrupted hepatic lobule structure,swollen hepatocytes,disordered arrangement,and a multi-tude of varying-sized lipid vacuoles within the cytoplasm.Conversely,rats treated with different doses of the herbal remedy exhibited improvements in liver tissue pathology,with the high-dose group showing the most notable enhancement.Conclusion:Lizhong Tang can improve NAFLD disease by regulating mitochondrial autophagy.
文摘为获取气固两相流浓度与超声波能量衰减关系,分析了超声波衰减原理与气固两相流流体模型,搭建了气固两相流超声波测量试验平台,利用重力输送试验装置产生气固两相流流体,在超声波换能器之间距离为0.2 m,采用频率为50 k Hz换能器进行测量试验;分析处理大量试验数据,拟合出一定距离下超声波衰减情况与气固两相流体浓度变化的近似映射函数,并通过区间估计表征测量数据置信度区间。试验发现,在超声波发射接收距离一定、发射频率一定时,气固两相流体浓度越大,超声波衰减信号也越大。验证了采用超声波测量技术方法对于气固两项流浓度相关参数的检测是可行有效的。
