期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Polymorphisms of the Vitamin D Receptor Gene and SexDifferential Associations with Lipid Profiles in Chinese Han Adults 被引量:1
1
作者 CHEN Yan Mei XU Ping +5 位作者 wang zhou tian ZHU Yu Mei GONG Chun Mei HUANG Chang Hua LIU Xiao Li zhou Ji Chang 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2022年第2期115-125,共11页
Objective To explore the association of single nucleotide polymorphisms(SNPs)of the vitamin D receptor gene(VDR)with circulating lipids considering gender differences.Methods Of the Han Chinese adults recruited from a... Objective To explore the association of single nucleotide polymorphisms(SNPs)of the vitamin D receptor gene(VDR)with circulating lipids considering gender differences.Methods Of the Han Chinese adults recruited from a health examination center for inclusion in the study,the circulating lipids,25-hydroxyvitamin D(25OHD),and other parameters were measured.The VDR SNPs of Cdx2(rs11568820),Fok1(rs2228570),Apa1(rs7975232),and Taq1(rs731236)were genotyped with a qPCR test using blood DNA samples,and their associations with lipids were analyzed using logistic regression.Results In the female participants(n=236 with dyslipidemia and 888 without dyslipidemia),multiple genotype models of Fok1 indicated a positive correlation of B(not A)alleles with LDLC level(P<0.05).In the male participants(n=299 with dyslipidemia and 564 without dyslipidemia),the recessive model of Cdx2 and the additive and recessive models of Fok1 differed(P<0.05)between the HDLC-classified subgroups,respectively,and Fok1 BB and Cdx2 TT presented interactions with 25OHD in the negative associations with HDLC(P<0.05).Conclusion In the Chinese Han adults included in the study,the Fok1 B-allele of VDR was associated with higher LDLC in females,and the Fok1 B-allele and the Cdx2 T-allele of VDR were associated with lower HDLC in males.The interaction of VD and Fok1 BB or Cdx2 TT in males synergistically decreased HDLC levels. 展开更多
关键词 Vitamin D Vitamin D receptor Gene polymorphism LIPID DYSLIPIDEMIA
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部