目的系统评价6种清热解毒类中药注射液联合常规西医治疗儿童毛细支气管炎的疗效与安全性。方法计算机检索中国期刊全文数据库(CNKI)、万方数据库(Wanfang)、维普数据库(VIP)、CBM、Web of Science、The Cochrane Library、PubMed和Embas...目的系统评价6种清热解毒类中药注射液联合常规西医治疗儿童毛细支气管炎的疗效与安全性。方法计算机检索中国期刊全文数据库(CNKI)、万方数据库(Wanfang)、维普数据库(VIP)、CBM、Web of Science、The Cochrane Library、PubMed和Embase数据库收录的清热解毒类中药注射液治疗儿童毛细支气管炎的随机对照试验(RCT),检索时间均自建库至2021年3月14日。提取合格文献相关信息,通过Cochrane风险偏倚评价工具对纳入研究进行质量评价。使用R软件、JAGS软件和GEMTC软件包进行贝叶斯网状Meta分析。结果最终纳入26项RCTs,涉及2776例患儿及喜炎平注射液、炎琥宁注射液、血必净注射液、热毒宁注射液、痰热清注射液、鱼腥草注射液6种清热解毒类中药注射液。网状Meta分析结果显示,与常规西医治疗相比,(1)提高临床总有效率方面,喜炎平注射液>炎琥宁注射液>血必净注射液>热毒宁注射液>痰热清注射液>鱼腥草注射液;(2)缩短憋喘时间方面,喜炎平注射液>痰热清注射液>热毒宁注射液>炎琥宁注射液>血必净注射液;(3)缩短咳嗽时间方面,热毒宁注射液>痰热清注射液>喜炎平注射液>血必净注射液;(4)肺部啰音消失方面,喜炎平注射液>鱼腥草注射液>热毒宁注射液>血必净注射液>炎琥宁注射液>痰热清注射液;(5)肺部哮鸣音消失方面,喜炎平注射液>热毒宁注射液>炎琥宁注射液>血必净注射液>痰热清注射液;(6)缩短平均住院时间方面,喜炎平注射液>炎琥宁注射液>热毒宁注射液>血必净注射液>鱼腥草注射液>痰热清注射液。6种清热解毒类中药注射液在治疗过程中均未产生严重不良反应。结论现有证据表明,清热解毒类中药注射液联合西医常规治疗可提高儿童毛细支气管炎的疗效,其中以喜炎平注射液总体治疗效果较好。展开更多
Two simple donor-acceptor multifunctional pure organic light-emitting molecules[(9H-carbazol-9-yl)(4-hydroxyphenyl)-methanone(CzMP)and(4-hydroxyphenyl)(10H-phenothiazin-10-yl)methanone(PTZMP)]with distinct aggregation...Two simple donor-acceptor multifunctional pure organic light-emitting molecules[(9H-carbazol-9-yl)(4-hydroxyphenyl)-methanone(CzMP)and(4-hydroxyphenyl)(10H-phenothiazin-10-yl)methanone(PTZMP)]with distinct aggregation-induced emission(AIE)properties were synthesized.Surprisingly,CzMP showed a long room temperature phosphorescence lifetime(>900 ms),and PTZMP exhibited triple emission of prompt fluorescence(PF),room temperature phosphorescence(RTP)and thermally activated delayed fluorescence(TADF).Furthermore,CzMP effectively responded to mechanical external forces and solvent fumigation,exhibiting dual-mode mechanochromic luminescence(MCL)including multiple fluorescence color shifts and phosphorescence switching.Time-dependent density functional theory(TDDFT)calculations were investigated to explain different luminescence properties of the two molecules,and the single crystal of CzMP was obtained and analyzed to demonstrate the unique molecular stacking pattern and strong intermolecular interactions in close association with phosphorescence emission.The multifunctional luminescent properties of the emitters explored in this work could be more effectively applied to a wide range of applications,such as information encryption and anti-counterfeiting.展开更多
文摘目的系统评价6种清热解毒类中药注射液联合常规西医治疗儿童毛细支气管炎的疗效与安全性。方法计算机检索中国期刊全文数据库(CNKI)、万方数据库(Wanfang)、维普数据库(VIP)、CBM、Web of Science、The Cochrane Library、PubMed和Embase数据库收录的清热解毒类中药注射液治疗儿童毛细支气管炎的随机对照试验(RCT),检索时间均自建库至2021年3月14日。提取合格文献相关信息,通过Cochrane风险偏倚评价工具对纳入研究进行质量评价。使用R软件、JAGS软件和GEMTC软件包进行贝叶斯网状Meta分析。结果最终纳入26项RCTs,涉及2776例患儿及喜炎平注射液、炎琥宁注射液、血必净注射液、热毒宁注射液、痰热清注射液、鱼腥草注射液6种清热解毒类中药注射液。网状Meta分析结果显示,与常规西医治疗相比,(1)提高临床总有效率方面,喜炎平注射液>炎琥宁注射液>血必净注射液>热毒宁注射液>痰热清注射液>鱼腥草注射液;(2)缩短憋喘时间方面,喜炎平注射液>痰热清注射液>热毒宁注射液>炎琥宁注射液>血必净注射液;(3)缩短咳嗽时间方面,热毒宁注射液>痰热清注射液>喜炎平注射液>血必净注射液;(4)肺部啰音消失方面,喜炎平注射液>鱼腥草注射液>热毒宁注射液>血必净注射液>炎琥宁注射液>痰热清注射液;(5)肺部哮鸣音消失方面,喜炎平注射液>热毒宁注射液>炎琥宁注射液>血必净注射液>痰热清注射液;(6)缩短平均住院时间方面,喜炎平注射液>炎琥宁注射液>热毒宁注射液>血必净注射液>鱼腥草注射液>痰热清注射液。6种清热解毒类中药注射液在治疗过程中均未产生严重不良反应。结论现有证据表明,清热解毒类中药注射液联合西医常规治疗可提高儿童毛细支气管炎的疗效,其中以喜炎平注射液总体治疗效果较好。
文摘Two simple donor-acceptor multifunctional pure organic light-emitting molecules[(9H-carbazol-9-yl)(4-hydroxyphenyl)-methanone(CzMP)and(4-hydroxyphenyl)(10H-phenothiazin-10-yl)methanone(PTZMP)]with distinct aggregation-induced emission(AIE)properties were synthesized.Surprisingly,CzMP showed a long room temperature phosphorescence lifetime(>900 ms),and PTZMP exhibited triple emission of prompt fluorescence(PF),room temperature phosphorescence(RTP)and thermally activated delayed fluorescence(TADF).Furthermore,CzMP effectively responded to mechanical external forces and solvent fumigation,exhibiting dual-mode mechanochromic luminescence(MCL)including multiple fluorescence color shifts and phosphorescence switching.Time-dependent density functional theory(TDDFT)calculations were investigated to explain different luminescence properties of the two molecules,and the single crystal of CzMP was obtained and analyzed to demonstrate the unique molecular stacking pattern and strong intermolecular interactions in close association with phosphorescence emission.The multifunctional luminescent properties of the emitters explored in this work could be more effectively applied to a wide range of applications,such as information encryption and anti-counterfeiting.