偏头痛是一种严重危害人类健康的脑疾病,其中无先兆偏头痛在临床中占比最多且诊断困难。当前无先兆偏头痛辅助诊断算法研究中,基于机器学习的脑影像功能连接分析方法是最主要的研究方向。由于此类方法多依赖于预定义的脑图谱模板,受模...偏头痛是一种严重危害人类健康的脑疾病,其中无先兆偏头痛在临床中占比最多且诊断困难。当前无先兆偏头痛辅助诊断算法研究中,基于机器学习的脑影像功能连接分析方法是最主要的研究方向。由于此类方法多依赖于预定义的脑图谱模板,受模板选择主观因素及分类器性能影响,现有方法的智能化程度和准确率较低,难以满足临床及研究需求。基于设计的新型3D-CNN技术,提出了一种无先兆偏头痛智能辅助诊断算法MwoA3D-Net(3D convolutional neural network based diagnosis of migraine without aura)。该算法采用组信息指导的独立成分分析方法,生成被试的静息态脑网络,并以此作为输入训练MwoA3D-Net,实现对无先兆偏头痛患者与健康对照的自动诊断,可避免因先验模板不同导致的结果差异。在算法设计中引入3D数据增强、L1和L2正则化等一系列优化策略,可有效防止过拟合现象的发生。在60名无先兆偏头痛和65名健康被试数据集上的实验结果表明,MwoA3DNet的平均诊断准确率为98.40%,鲁棒性较高,且所选静息态脑功能网络均具有较强的辨识性,可作为无先兆偏头痛的潜在生物标志物用于个体化诊断。展开更多
Objective The resting-state functional magnetic resonance imaging(rs-f MRI)method was used to observe brain activity and its functional connection upon electroacupuncture stimulation at bilateral uterine acupoints(EX-...Objective The resting-state functional magnetic resonance imaging(rs-f MRI)method was used to observe brain activity and its functional connection upon electroacupuncture stimulation at bilateral uterine acupoints(EX-CA1),as well as to investigate the mechanism of acupuncture in the treatment of gynecological diseases.Methods Twenty-two healthy female subjects were stimulated by electroacupuncture at bilateral uterine acupoints;rs-f MRI data of the brain were acquired and standardized.Degree centrality(DC),amplitude of low-frequency fluctuation(ALFF),and regional homogeneity(ReHo)were used to analyze local spontaneous brain activity via acupuncture.An independent component analysis was used to evaluate the functional connectivity of the resting brain networks after acupuncture.Results Analytical results showed that the neural activity intensity of the precuneus lobe,orbitofrontal cortex,lingual gyrus,amygdala,and posterior central gyrus decreased after acupuncture(voxel P<0.001,cluster P<0.05).Functional connectivity analysis revealed weakened auditory and right frontal-parietal networks(voxel P<0.001,cluster P<0.05),enhanced visual network(voxel P<0.001,cluster P<0.05),and synergistic auditory network and hypothalamic-pituitary system.Conclusion Significant differences in neural activity and functional connectivity in specific brain regions were observed after acupuncture intervention at uterine acupoints;the hypothalamic-pituitary system also showed various active states in different brain regions.It is speculated that the effective mechanism of acupuncture at uterine acupoints is related to the regulation of reproductive hormones,emotional changes,and somatic sensations.Therefore,the methods used in this study could clarify the neural mechanism of uterine-point acupuncture in the treatment of gynecological diseases and may serve as a reference for other studies pertaining to acupuncture.展开更多
文摘偏头痛是一种严重危害人类健康的脑疾病,其中无先兆偏头痛在临床中占比最多且诊断困难。当前无先兆偏头痛辅助诊断算法研究中,基于机器学习的脑影像功能连接分析方法是最主要的研究方向。由于此类方法多依赖于预定义的脑图谱模板,受模板选择主观因素及分类器性能影响,现有方法的智能化程度和准确率较低,难以满足临床及研究需求。基于设计的新型3D-CNN技术,提出了一种无先兆偏头痛智能辅助诊断算法MwoA3D-Net(3D convolutional neural network based diagnosis of migraine without aura)。该算法采用组信息指导的独立成分分析方法,生成被试的静息态脑网络,并以此作为输入训练MwoA3D-Net,实现对无先兆偏头痛患者与健康对照的自动诊断,可避免因先验模板不同导致的结果差异。在算法设计中引入3D数据增强、L1和L2正则化等一系列优化策略,可有效防止过拟合现象的发生。在60名无先兆偏头痛和65名健康被试数据集上的实验结果表明,MwoA3DNet的平均诊断准确率为98.40%,鲁棒性较高,且所选静息态脑功能网络均具有较强的辨识性,可作为无先兆偏头痛的潜在生物标志物用于个体化诊断。
基金National Nature Science Foundation of China(61872225)Natural Science Foundation of Shandong Province(ZR2020KF013,ZR2020ZD44,ZR2019ZD04,and ZR2020QF043)+1 种基金Introduction and Cultivation Program for Young Creative Talents in Colleges and Universities of Shandong Province(2019-173)Special Fund of Qilu Health and Health Leading Talents Training Project。
文摘Objective The resting-state functional magnetic resonance imaging(rs-f MRI)method was used to observe brain activity and its functional connection upon electroacupuncture stimulation at bilateral uterine acupoints(EX-CA1),as well as to investigate the mechanism of acupuncture in the treatment of gynecological diseases.Methods Twenty-two healthy female subjects were stimulated by electroacupuncture at bilateral uterine acupoints;rs-f MRI data of the brain were acquired and standardized.Degree centrality(DC),amplitude of low-frequency fluctuation(ALFF),and regional homogeneity(ReHo)were used to analyze local spontaneous brain activity via acupuncture.An independent component analysis was used to evaluate the functional connectivity of the resting brain networks after acupuncture.Results Analytical results showed that the neural activity intensity of the precuneus lobe,orbitofrontal cortex,lingual gyrus,amygdala,and posterior central gyrus decreased after acupuncture(voxel P<0.001,cluster P<0.05).Functional connectivity analysis revealed weakened auditory and right frontal-parietal networks(voxel P<0.001,cluster P<0.05),enhanced visual network(voxel P<0.001,cluster P<0.05),and synergistic auditory network and hypothalamic-pituitary system.Conclusion Significant differences in neural activity and functional connectivity in specific brain regions were observed after acupuncture intervention at uterine acupoints;the hypothalamic-pituitary system also showed various active states in different brain regions.It is speculated that the effective mechanism of acupuncture at uterine acupoints is related to the regulation of reproductive hormones,emotional changes,and somatic sensations.Therefore,the methods used in this study could clarify the neural mechanism of uterine-point acupuncture in the treatment of gynecological diseases and may serve as a reference for other studies pertaining to acupuncture.