Longitudinal changes in body weight of breastfeeding mothers in the first year after delivery and its relationship with human milk composition:a combined longitudinal and cross-sectional cohort study

Objective:Postpartum weight retention(PPWR)is a common problem among women after childbirth.The main objectives of this study are to understand the changes in body weight of breastfeeding mothers during long-term follow-up and preliminarily explore the relationship between maternal body weight and human milk composition,including macronutrients,leptin,and adiponectin.Methods:The study included a longitudinal cohort(122 mothers),and a cross-sectional cohort(37 mothers).The human milk,maternal weight,and dietary surveys were collected in the longitudinal cohort at different follow-up time points(1-14 days postpartum,2-4 months postpartum,5-7 months postpartum,and 12-17 months postpartum).The maternal body weight was analyzed using the responses in the survey questionnaires.A milk analyzer based on the mid-infrared spectroscopy(MIRS)was used to determine milk composition,and nutrition analysis software evaluated dietary intakes.In the cross-sectional cohort,participating mothers were asked to provide blood and human milk samples and pertinent information related to maternal body composition.Maternal body composition was measured by bioelectrical impedance analysis(BIA),while ELISA analyzed leptin and adiponectin in milk and serum.Results:At 5-7 months postpartum,the PPWR of breastfeeding mothers was(2.46±3.59)kg.At 12-17 months postpartum,the PPWR was(0.98±4.06)kg.PPWR was found to be negatively correlated with milk fat content within 14 days postpartum and positively correlated at 2-4 months postpartum.In addition,the maternal weight and body muscle mass were positively correlated with leptin and adiponectin in milk.Plasma leptin was positively correlated with the mother’s body weight,body mass index(BMI),FAT percentage,and body fat mass,while plasma adiponectin did not correlate with any parameter.The results also indicate that the PPWR did not correlate with leptin and adiponectin in plasma or milk.Conclusions:Breastfeeding mothers may retain considerable weight gain one year after delivery.Human milk composition may be related to changes in maternal body weight.Leptin and adiponectin in breast milk and leptin in plasma are associated with the maternal body composition.This study supports the notion that maternal nutritional status may affect offspring health through lactation,and future research should focus on exploring weight management of postpartum mothers.

Intelligent In-Vehicle Safety System Based on Yolov5

In order to reduce the occurrence of traffic accidents and assist drivers to avoid dangerous driving. This paper presents a smart in-vehicle safety system that utilises the Yolov5 algorithm. Yolov5 algorithm is used to anticipate driver fatigue and distraction behaviours, and remind drivers to pay attention to safe driving in time. The system continuously splits the frames and analyses the frame content through the video feedback from the front camera, compared to the traditional machine learning, Yolov5’s mosaic data is enhanced, resulting in a batch size enhancement of 92.3%, and it also uses the Drop Block mechanism to prevent overfitting. The hardware of this system uses STM32 microcontroller and uses system DMA interrupt control and buzzer alarm device to warn about dangerous driving behaviour.

Emerging role of regulated cell death in intestinal failure-associated liver disease

Intestinal failure-associated liver disease(IFALD)is a common complication of long-term parenteral nutrition that is associated with significant morbidity and mortality.It is mainly characterized by cholestasis in children and steatohepatitis in adults.Unfortunately,there is no effective approach to prevent or reverse the disease.Regulated cell death(RCD)represents a fundamental biological paradigm that determines the outcome of a variety of liver diseases.Nowadays cell death is reclassified into several types,based on the mechanisms and morphological phenotypes.Emerging evidence has linked different modes of RCD,such as apoptosis,necroptosis,ferroptosis,and pyroptosis to the pathogenesis of liver diseases.Recent studies have shown that different modes of RCD are present in animal models and patients with IFALD.Understanding the pathogenic roles of cell death may help uncover the underlying mechanisms and develop novel therapeutic strategies in IFALD.In this review,we discuss the current knowledge on how RCD may link to the pathogenesis of IFALD.We highlight examples of cell death-targeted interventions aiming to attenuate the disease,and provide perspectives for future basic and translational research in the field.

The role of exercise in modulating the HP pathway to reduce glioma-induced epilepsy

Background:Glioma-induced refractory epilepsy can be alleviated through conventional exercise,providing a potential therapeutic approach to manage this condition.This study aims to investigate the underlying mechanisms.Methods:Bioinformatics methodologies were employed to scrutinize gene expression data from public repositories such as GEO,with a specific focus on mobility-related genes in epilepsy.Through differential and enrichment analyses,differentially expressed genes(DEGs)were identified,while protein-protein interaction networks elucidated pivotal hub genes.Results:Our analysis revealed 32 DEGs,comprising 23 upregulated and 9 downregulated genes.Enrichment analysis underscored significant alterations in immune pathways in epilepsy.Two central hub genes,haptoglobin(HP)and prostaglandin-endoperoxide synthase 2(PTGS2),were found to be modulated by Arginase 1(ARG1)and Chemokine(C-X-C motif)ligand 8(CXCL8).GSVA analysis associated elevated PTGS2 expression with metabolic pathways,while increased HP expression was correlated with angiogenesis and inflammation.Subsequent experiments validated HP’s role in tumor cell proliferation,emphasizing its potential as a therapeutic target.Conclusion:This study highlights the crucial involvement of HP and PTGS2 genes in the etiology of epilepsy,linked to discrepancies in the immune system.These findings offer fresh perspectives on the management of epilepsy,emphasizing the neuroprotective possibilities of targeting specific gene pathway.

饱水和天然状态下页岩滞后效应及阻尼特性研究

运用RLW-2000型微机伺服岩石三轴试验机,对饱水状态和天然状态页岩在不同围压下进行三轴循环加卸载试验,分析了两种含水状态页岩的力学特性和滞后效应,并基于能量原理讨论了阻尼比演化规律。试验结果表明:随循环次数增加,累积残余应变逐渐增加,相对残余应变先降低,后趋于稳定区域,直至破坏前急剧增加;饱水页岩的加卸载变形模量均比天然页岩小,加载变形模量整体比卸载变形模量小;在加载和卸载阶段,均出现应变始终滞后于应力的现象;饱水页岩的滞后效应比天然页岩更明显。提出了考虑滞后效应的能量计算方法,较以往能量计算的误差更小。最后基于能量原理对阻尼比的计算公式进行修正,发现饱水页岩的阻尼比比天然页岩大。阻尼比的变化较好地反映了页岩损伤机制,可作为预判页岩失稳破坏的重要指标。

甘肃省金塔北海子国家湿地公园水鸟多样性调查初报

为探明甘肃金塔北海子国家湿地公园水鸟多样性现状,笔者于2017年8月、2017年11月和2018年4月,采用样带法调查了金塔北海子国家湿地公园水鸟的种群数量并进行多样性分析。调查共记录到水鸟31种,隶属于7目10科23属;秋季迁徙期水鸟的种群密度较大,形成规模较大的单优种群,但多样性和均匀度指数均小于其他季节;南北岸水鸟的群落构成和优势物种不尽相同且相似性指数不高。

某医院静脉用药调配中心不合理处方分析

目的分析某医院静脉用药调配中心不合理处方,不断提升医院合理用药水平。方法采用回顾性分析方法,从不合理处方的类型、科室分布、高警示药品、发现途径等方面,对安徽医科大学第二附属医院2015—2018年13876组不合理处方进行统计分析。结果总不合理处方占总处方的0.17%;溶媒规格不当是数量最多的类型,占总不合理处方数的47.64%;ICU是不合理处方数量最多的科室,占本科室总处方数的0.92%;高警示药品中非肠道和口服化疗药占比最高,占此类总处方数的0.53%;审方时发现的最多,占62.71%;干预成功率为99.85%。结论审方药师进行用药干预可有效降低不合理处方,提高静脉药物的合理用药水平。

综合考虑尺寸和应变速率的单晶Ni_(3)Al屈服强度的理论模型

为了综合考虑尺寸和应变率效应对单晶延性材料屈服强度的影响,建立基于位错形核机制的理论模型。以Ni_(3)Al为例,首先,通过分子动力学模拟结果拟合出材料参数;然后,通过材料参数构建屈服强度的理论曲面;最后,用现有实验数据检验该理论模型。通过现有第三方单晶铜和金的分子动力学和实验数据对该模型进行检验。结果表明,该模型可以跨越分子动力学和实验条件之间巨大的空间和时间差异,从而得到单晶Ni_(3)Al、铜和金的可靠力学性能。

Influence of dexamethasone on inflammatory mediators and NF-κB expression in multiple organs of rats with severe acute pancreatitis

AIM: To observe the therapeutic effects of dexamethasone on rats with severe acute pancreatitis (SAP) and investigate the influences of dexamethasone on the inflammatory mediators and NF-κB expression in multiple organs of SAP rats as well as the mechanisms involved. METHODS: Ninety Sprague-Dawley (SD) rats with SAP were randomly divided into the model group (n = 45) and dexamethasone treatment group (n = 45), and another 45 rats were selected for the sham operation group. All groups were randomly subdivided into the 3 h, 6 h and 12 h groups, each group containing 15 rats. The survival of all groups and pathological changes of multiple organs (liver, kidney and lung) were observed at different time points after the operation. The pathologicalscore of multiple organs was carried out, followed by the determination of amylase, endotoxin and TNF-α contents in blood. The tissue microarray was used to detect the expression levels of NF-κB p65 protein in multiple organs. RESULTS: There was no marked difference between the model group and treatment group in the survival rate. The amylase content of the treatment group was significantly lower compared to the model group at 12 h (P < 0.01, 7791.00 vs 9195.00). Moreover, the endotoxin and TNF-α levels of the treatment group were significantly lower than that of the model group at 6 h and 12 h (P < 0.01, 0.040 vs 0.055, 0.042 vs 0.059 and P < 0.05, 58.30 vs 77.54, 38.70 vs 67.30, respectively). Regarding the changes in liver NF-κB expression, the model group significantly exceeded the sham operation group at 3 h (P < 0.01, 1.00 vs 0.00), and the treatment group significantly exceeded the sham operation group at 12 h (P < 0.01, 1.00 vs 0.00), whereas no marked difference was observed between the model group and treatment group at all time points. The kidney NF-κB expression level in the treatment group significantly exceeded the model group (P < 0.05, 2.00 vs 0.00) and the sham operation group (P < 0.01, 2.00 vs 0.00) at 12 h. No NF-κB expression in the lung was found in any group. CONCLUSION: Dexamethasone can lower the amylase, endotoxin and TNF-α levels as well as mortality of SAP rats. NF-κB plays an important role in multiple organ injury. Further studies should be conducted to determine whether dexamethasone can ameliorate the pathological changes of multiple organs by reducing the NF-κB expression in the liver and kidney. The advantages of tissue microarrays in pancreatitis pathological examination include time- and energy- saving, and are highly efficient and representative. The restriction of tissue microarrays on the representation of tissues to various extents due to small diameter may lead to the deviation of analysis.

T-PBFT: An EigenTrust-Based Practical Byzantine Fault Tolerance Consensus Algorithm

Blockchain with these characteristics of decentralized structure, transparent and credible, time-series and immutability, has been considering as a promising technology. Consensus algorithm as one of the core techniques of blockchain directly affects the scalability of blockchain systems. Existing probabilistic finality blockchain consensus algorithms such as PoW, PoS, suffer from power consumptions and low efficiency;while absolute finality blockchain consensus algorithms such as PBFT, HoneyBadgerBFT, could not meet the scalability requirement in a largescale network. In this paper, we propose a novel optimized practical Byzantine fault tolerance consensus algorithm based on EigenTrust model, namely T-PBFT, which is a multi-stage consensus algorithm. It evaluates node trust by the transactions between nodes so that the high quality of nodes in the network will be selected to construct a consensus group. To reduce the probability of view change, we propose to replace a single primary node with a primary group. By group signature and mutual supervision, we can enhance the robustness of the primary group further. Finally, we analyze T-PBFT and compare it with the other Byzantine fault tolerant consensus algorithms. Theoretical analysis shows that our T-PBFT can optimize the Byzantine fault-tolerant rate,reduce the probability of view change and communication complexity.

Disruption of interstitial cells of Cajal networks after massive small bowel resection

AIM: To investigate the disruptions of interstitial cells of Cajal (ICC) in the remaining bowel in rats after massive small bowel resection (mSBR). METHODS: Thirty male Sprague-Dawley rats fitting entry criteria were divided randomly into three experimental groups (n = 10 each): Group A rats underwent bowel transection and re-anastomosis (sham) and tissue samples were harvested at day 7 post-surgery. Group B and C rats underwent 80% small bowel resection with tissue harvested from Group B rats at day 7 post-surgery, and from Group C rats at day 14 postsurgery. The distribution of ICC at the site of the resid-ual small bowel was evaluated by immunohistochemical analysis of small intestine samples. The ultrastructural changes of ICC in the remnant ileum of model rats 7 and 14 d after mSBR were analyzed by transmission electron microscopy. Intracellular recordings of slow wave oscillations were used to evaluate electrical pacemaking. The protein expression of c-kit, ICC phenotypic markers, and membrane-bound stem cell factor (mSCF) in intestinal smooth muscle of each group were detected by Western blotting. RESULTS: After mSBR, immunohistochemical analysis indicated that the number of c-kit-positive cells was dramatically decreased in Group B rats compared with sham tissues. Significant ultrastructural changes in ICC with associated smooth muscle hypertrophy were also observed. Disordered spontaneous rhythmic contractions with reduced amplitude (8.5 ± 1.4 mV vs 24.8 ± 1.3 mV, P = 0.037) and increased slow wave frequency (39.5 ± 2.1 cycles/min vs 33.0 ± 1.3 cycles/min, P = 0.044) were found in the residual intestinal smooth muscle 7 d post mSBR. The contractile function and electrical activity of intestinal circular smooth muscle returned to normal levels at 14 d post mSBR (amplitude, 14.9 ± 1.6 mV vs 24.8 ± 1.3 mV; frequency, 30.7 ± 1.7 cycles/min vs 33.0 ± 1.3 cycles/min). The expression of Mscf and c-kit protein was decreased at 7 d (P = 0.026), but gradually returned to normal levels at 14 d. The ICC and associated neural networks were disrupted, which was associated with the phenotype alterations of ICC. CONCLUSION: Massive small bowel resection in rats triggered damage to ICC networks and decreased the number of ICC leading to disordered intestinal rhythmicity. The mSCF/c-kit signaling pathway plays a role in the regulation and maintenance of ICC phenotypes.

Bacterial infection triggers and complicates acute-on-chronic liver failure in patients with hepatitis B virus-decompensated cirrhosis: A retrospective cohort study

BACKGROUND Reports on bacterial infection(BI)in decompensated cirrhosis(DC)is mainly from alcoholic cirrhosis.The role of BI as a trigger or complication of acute-onchronic liver failure(ACLF)in patients with hepatitis B virus decompensated cirrhosis(HBV-DC)remains to be investigated.AIM To investigate the impact of BI on the outcomes of the patients with HBV-DC admitted into the hospital with or without ACLF.METHODS This retrospective study included patients with HBV-DC admitted to two tertiary centers in China.In-hospital overall survival,90-d transplant-free survival,5-year post-discharge survival,and cumulative incidence of ACLF were evaluated.Risk factors for death were analyzed considering liver transplantation as a competing event.RESULTS A total of 1281 hospitalized HBV-DC patients were included;284 had ACLF at admission.The overall prevalence of BI was 28.1%.The patients with BI had a significantly lower in-hospital survival and transplant-free 90-d survival than those without,in both the patients admitted with and without ACLF.The presence of BI significantly increased the risk of developing ACLF[subdistribution hazard ratio(sHR)=2.52,95%CI:1.75-3.61,P<0.001]in the patients without ACLF.In the patients discharged alive,those who had an episode of BI had a significantly lower 5-year transplant-free survival.BI was an independent risk factor for death in the patients admitted without ACLF(sHR=3.28,95%CI:1.93-5.57),while in ACLF admissions,the presence of pneumonia,but not other type of BI,independently increased the risk of death(sHR=1.87,95%CI:1.24-2.82).CONCLUSION BI triggers ACLF in patients with HBV-DC and significantly impairs short-term survival.HBV-DC patients should be monitored carefully for the development of BI,especially pneumonia,to avoid an adverse outcome.

Evaluation of HCPTd_1, d_(14)-double passaged intervening chemotherapy protocol for hepatocellular carcinoma

AIM. To establish a kind of standardization of the clinical chemotherapeutic prototypes for unresectable hepatocellular carcinomas （HCC）. METHODS： 10-Hydroxycamptothecin （HCPT） was applied through transcatheter arterial embolization （TAE） to HCC patients who were categorized into three groups： （1） test group： treatment with HCPT twice （HCPT dl and 14） through TAE and portal venous embolization. （2） Control Ⅰ： treatment with anticancer drugs without HCPT. （3） Control Ⅱ： treatment with HCPT as a major component in anticancer drugs once （HCPT dl）. A set of comparisons between test groups and control Ⅰ and Ⅱ groups were performed before and after the treatment to study the effectiveness of each treatment, in terms of tumor volumes, dynamic variations in serum alpha-fetoprotein （AFP）, gamma-glutamyl transferase hepatoma-specific band （GGT-Ⅱ）, patient survival and adverse events. RESULTS： The general effectiveness rate of the test group reached 62.1% （72/116）, remarkably higher than that of control Ⅰ （32.1%, 40/124） and control Ⅱ （54.7%, 47/56）, （P〈0.01 and P〈0.05, respectively）. Especially, the reduction rate or disappearance of the portal vein tumor emboli was as high as 88.4% （61/69） in the test group, in contrast with 13.9% （10/72） in control Ⅰ and 35.9% （18/51） in control Ⅱ （P〈0.01 and P〈0.01, respectively）. After treatment, AFP decreased or turned to negative levels at 52.3% （34/65） in control Ⅰ, 67.3% （35/52） in control Ⅱ, and 96.8% （60/62） in the test group. Also GGT-Ⅱ declined or became negative at 37.8% （28/74） in control Ⅰ, 69.5% （57/82） in control Ⅱ, and 94.7% （89/94） in test group （P〈0.01 and P〈0.05, respectively）. CONCLUSION： We have designed a good protocol （test group） to treat HCC with excellent advantages of high efficiency, low cost, low toxicity and low adverse events and easy application. It could be recommended as one of the standardizations for HCC treatment in clinical practice.

Shaped charge penetration into high-and ultrahigh-strength Steel-Fiber reactive powder concrete targets

Experiments on shaped charge penetration into high and ultrahigh strength steel-fiber reactive powder concrete(RPC) targets were performed in this paper.Results show that the variation of penetration depth and crater diameter with concrete strength is different from that of shaped charge penetration into normal strength concrete(NSC).The crater diameter of RPC is smaller than that of NSC penetrated by the shaped charge.The jet particles are strongly disturbed and hardly reach the crater bottom because they pass through the narrow channel formed by jet penetration into the RPC.The effects of radial drift velocity and gap effects of jet particles for a shaped charge penetration into RFC target are discussed.Moreover,a theoretical model is presented to describe the penetration of shaped charge into RPC target.As the concrete strength increases,the penetration resistance increases and the entrance crater diameter decreases.Given the drift velocity and narrow crater channel,the low-velocity jet particles can hardly reach the crater bottom to increase the penetration depth.Moreover,the narrow channel has a stronger interference to the jet particles with increasing concrete strength;hence,the gap effects must be considered.The drift velocity and gap effects,which are the same as penetration resistance,also have significant effects during the process of shaped charge penetration into ultrahigh-strength concrete,The crater profiles are calculated through a theoretical model,and the results are in good agreement with the experiments.

Application of artificial intelligence in preoperative imaging of hepatocellular carcinoma:Current status and future perspectives

Hepatocellular carcinoma(HCC)is the most common primary malignant liver tumor in China.Preoperative diagnosis of HCC is challenging because of atypical imaging manifestations and the diversity of focal liver lesions.Artificial intelligence(AI),such as machine learning(ML)and deep learning,has recently gained attention for its capability to reveal quantitative information on images.Currently,AI is used throughout the entire radiomics process and plays a critical role in multiple fields of medicine.This review summarizes the applications of AI in various aspects of preoperative imaging of HCC,including segmentation,differential diagnosis,prediction of histo-pathology,early detection of recurrence after curative treatment,and evaluation of treatment response.We also review the limitations of previous studies and discuss future directions for diagnostic imaging of HCC.

Spalling failure of deep hard rock caverns

Spalling is a typical brittle failure phenomenon of hard rock in deep caverns under high geostress.In this study,key issues are systematically studied concerning the spalling failure of deep hard rock caverns.First,the prismatic rock specimens with small thicknesses(i.e.width×thickness×height:20 mm×50 mm×100 mm)are employed in our tests which not only successfully simulate the spalling failure of hard rock in the laboratory but also obtain a reasonable spalling strength similar to that of the rock mass.Then,a series of spalling experiments is carried out to investigate the mechanism of spalling failure of deep hard rock caverns.Our results show that the intermediate principal stress,weak dynamic disturbances,and rock microstructure have significant effects on the spalling failure.The spalling strength is approximately(0.3–0.8)UCS,where UCS is the uniaxial compressive strength of the cylindrical rock sample with a diameter of around 50 mm.The spalling strength increases first and then decreases with increasing intermediate principal stress.Moreover,an empirical spalling strength criterion and a numerical method of spalling failure are proposed.This numerical method can not only simulate the spalling failure zone formed by tangential compressive stress concentration after excavation under different intermediate principal stresses,but also successfully simulate the failure transition from tensile mode to shear mode associated with confinement change in deep hard rock caverns.Furthermore,an acoustic emission-based early warning method using neural network is proposed to predict the spalling failure.Finally,a technical roadmap for preventing and controlling spalling failure of deep hard rock caverns is presented after summarizing the successful experiences in a typical engineering case.

Recovery Stress in a Ni-Ti-Nb Shape Memory Alloy with Wide Transformation Hysteresis

The effect of deformation on recovery stress of Ni144.7Ti46.3Nb9 alloy has been studjed using tensile test at various temperatures and TEM observation. It ls shown that the recovery stress increases with jncreasing total strain ET and reaches a maximum value (max) as ET= 9% but the maximum recov erV strain of the alloy is only about 4.6%. This is different from that of Ti-Ni binary alloy in which is obtained usually at maximum recovery strain and the reason of the difference is dis Cussed. Deformation temperature Td has a little effect on recovery stress when Td is less than Ms However, recovery stress decreases sharply when Td is higher than M, and lowers approximately down to zero near Msσ

Expert Consensus on Nutritional Support for Children with Congenital Heart Disease(2023 Edition)

The second edition of the expert consensus on pediatric nutrition was formed based on a global update of pedia-tric nutrition guidelines or consensus worldwide,the management of congenital heart disease,and the results of multi-center clinical nutrition research for congenital heart disease following thefirst Chinese consensus edition of 2016.The consensus was also shaped by the results of three discussion sessions and two questionnaires con-ducted by the 13-member collaboration group.This process was informed by both clinical guidelines and expert consensus.The quality of literature,both in English and Chinese,and the level of recommendations were evaluated using the Grading of Recommendations Assessment,Development,and Evaluations(GRADE)system.

Transitional care for patients with chronic obstructive pulmonary disease

Objectives:To observe the effects of transitional care on the quality of life of chronic obstructive pulmonary disease(COPD)patients.Methods:A total of 114 COPD patients were recruited from the First Affiliated Hospital,Sun Yat-sen University,Guangzhou,China and divided equally into an intervention group and control group.Following discharge,patients from the intervention group recieved threemonths intervention in addition to regular nursing care,while control group patients received regular nursing care only.Patients’quality of life was measured using the St.George’s respiratory questionnaire(SGRQ),the 12-item General Health Questionnaire(GHQ-12)and body mass index(BMI).Results:The symptoms section score,the activity section score,the impacts section score,the total score and the rate of mental disorders were significantly changed after the intervention while there was no statistical difference in BMI between groups.Conclusions:Transitional care can improve health-related quality of life in COPD patients who have recently suffered an exacerbation.

直接前侧入路全髋关节置换术治疗老年股骨颈骨折的效果及安全性分析

目的:探讨直接前侧入路(DAA)全髋关节置换术(THA)治疗老年股骨颈骨折的临床效果及安全性。方法:选取2019年6月-2020年12月来宾市人民医院住院部收治的106例老年股骨颈骨折患者为研究对象,随机分为对照组(n=53)和观察组(n=53)。对照组经后外侧入路行全髋关节置换术,观察组经直接前侧入路行全髋关节置换术。比较两组患者手术时长、术中出血量、下床活动时间、住院时间、疼痛程度、炎症指标、髋关节功能以及并发症发生情况。结果:观察组患者术中出血量少于对照组、术后1 d 视觉模拟评分法(VAS)评分低于对照组,下床活动时间、住院时间均短于对照组,差异均有统计学意义(P<0.05)。术后1 d,两组患者血清C反应蛋白(CRP)、白细胞计数(WBC)水平均明显升高,观察组患者血清CRP、WBC水平均低于对照组,差异均有统计学意义(P<0.05)。观察组术后1、3个月髋关节Harris评分均高于对照组,差异均有统计学意义(P<0.05)。观察组并发症发生率为9.4%,略低于对照组的17.0%,但差异无统计学意义(P>0.05)。结论:经DAA行全髋关节置换术可促进老年股骨颈骨折患者术后康复,有利于髋关节的早期恢复,且安全性良好。