Curcum in, a dietary phytochemical, exhibits multifunctional natural product with regulatory effects on inflammation. However, the poor bioavailability limits its clinical applications. Thus, we designed and synthesiz...Curcum in, a dietary phytochemical, exhibits multifunctional natural product with regulatory effects on inflammation. However, the poor bioavailability limits its clinical applications. Thus, we designed and synthesized a novel monocarbonyl analogue of curcumin B7 and their inhibition against monocyte chemotactic protein-1(MCP-1) and interleukin-8(IL-8) release was evaluated in H_2O_2-stimulated human vascular endothelial cells(ECs) in a dose-responsive manner, while exhibiting no cytotoxicity in ECs. Taken together, these insights on the novel compound B7 may serve as potential agents for the treatment of atherosclerosis.展开更多
基金National Natural Science Foundation of Chinagrant number:30800449+1 种基金Scientific Research Foundation for University of South Chinagrant number:2011XQD11
文摘Curcum in, a dietary phytochemical, exhibits multifunctional natural product with regulatory effects on inflammation. However, the poor bioavailability limits its clinical applications. Thus, we designed and synthesized a novel monocarbonyl analogue of curcumin B7 and their inhibition against monocyte chemotactic protein-1(MCP-1) and interleukin-8(IL-8) release was evaluated in H_2O_2-stimulated human vascular endothelial cells(ECs) in a dose-responsive manner, while exhibiting no cytotoxicity in ECs. Taken together, these insights on the novel compound B7 may serve as potential agents for the treatment of atherosclerosis.
