炎症反应是机体常见的生理、病理活动,炎症小体在该反应中发挥重要调控作用。核苷酸结合寡聚化结构域样受体蛋白3(NOD-like receptor protein 3,NLRP3)是炎症小体中关键的调控蛋白之一。研究发现激活NLRP3的刺激因子及其相关分子调控信...炎症反应是机体常见的生理、病理活动,炎症小体在该反应中发挥重要调控作用。核苷酸结合寡聚化结构域样受体蛋白3(NOD-like receptor protein 3,NLRP3)是炎症小体中关键的调控蛋白之一。研究发现激活NLRP3的刺激因子及其相关分子调控信号通路与多种疾病的发生、发展密切相关,并越来越受到广泛关注,是临床药物研究开发的前沿热点方向。总结NLRP3炎症小体的生物结构、调控功能、信号通路和作用机制等研究进展,并梳理与其相关靶点抑制剂的研究结果,对开展炎症相关疾病的新靶标药物发现及其临床应用研究具有重要的参考价值。展开更多
Background The study was to access the feasibility and effectiveness of permanent left bundle branch pacing(LBBP)in patients with bradycardia after cardiac surgery,in comparison with conventional right ventricular out...Background The study was to access the feasibility and effectiveness of permanent left bundle branch pacing(LBBP)in patients with bradycardia after cardiac surgery,in comparison with conventional right ventricular outflow tract septal pacing(RVOSP).Methods A total of 50 patients with cardiac surgery who underwent permanent pacemaker implantation(PPI)were enrolled,21 patients underwent LBBP(LBBP group)and 29 patients underwent RVOSP(RVOSP group).Pacing electrical parameters,QRS duration(QRSd),echocardiographic measurements,lead and device related complications were obtained at procedure and during follow-ups.Results There were no statistically significant differences between the LBBP group and the RVOSP group at procedure and at the twelfth month’s follow-up in pacing thresholds(0.64±0.16 V vs.0.63±0.22 V)and(0.91±0.28 V vs.0.85±0.20 V),R-wave amplitude(16.68±4.52 mV vs.15.09±4.53 mV)and(14.41±8.65 mV vs.12.65±6.17 mV),pacing impedances(719.24±152.65Ωvs.639.13±177.04Ω)and(534.01±96.92Ωvs.499.18±77.87Ω).But the average ventricular pacing percentage(VP%)at the first month’s follow-up(81.96±32.06%vs.58.37±42.96%)and at the twelfth month’s follow-up(84.65±35.84%vs.53.57±38.47%)showed significant difference between two groups(P<0.05);The LBBP group produced narrower QRSd(121.13±23.91 ms)than the RVOSP group(158.00±9.69 ms)(P=0.011).There were no significant differences between the LBBP group and the RVOSP group at pre-procedure and at the twelfth month’s follow-up in echocardiographic parameters,which included left ventricular end-diastolic dimension(LVEDD)(48.76±7.08 mm vs.47.34±6.91 mm)and(50.58±10.33 mm vs.45.97±7.11 mm),left ventricular ejection fraction(LVEF)(58.33±12.64%vs.61.50±8.40%)and(55.85±16.35%vs.61.50±10.52%),and area of tricuspid regurgitation(TR)(2.79±3.65 cm2 vs.2.85±2.26 cm2)and(3.09±2.34 cm2 vs.2.95±1.92 cm2).No lead and device related complication was observed during follow-ups.Conclusions LBBP is feasible and effective in patients with bradycardia after cardiac surgery.LBBP produces narrow QRSd,which may be a preferred pacing strategy for patients after cardiac surgery.[S Chin J Cardiol 2021;22(1):13-20]展开更多
文摘炎症反应是机体常见的生理、病理活动,炎症小体在该反应中发挥重要调控作用。核苷酸结合寡聚化结构域样受体蛋白3(NOD-like receptor protein 3,NLRP3)是炎症小体中关键的调控蛋白之一。研究发现激活NLRP3的刺激因子及其相关分子调控信号通路与多种疾病的发生、发展密切相关,并越来越受到广泛关注,是临床药物研究开发的前沿热点方向。总结NLRP3炎症小体的生物结构、调控功能、信号通路和作用机制等研究进展,并梳理与其相关靶点抑制剂的研究结果,对开展炎症相关疾病的新靶标药物发现及其临床应用研究具有重要的参考价值。
文摘Background The study was to access the feasibility and effectiveness of permanent left bundle branch pacing(LBBP)in patients with bradycardia after cardiac surgery,in comparison with conventional right ventricular outflow tract septal pacing(RVOSP).Methods A total of 50 patients with cardiac surgery who underwent permanent pacemaker implantation(PPI)were enrolled,21 patients underwent LBBP(LBBP group)and 29 patients underwent RVOSP(RVOSP group).Pacing electrical parameters,QRS duration(QRSd),echocardiographic measurements,lead and device related complications were obtained at procedure and during follow-ups.Results There were no statistically significant differences between the LBBP group and the RVOSP group at procedure and at the twelfth month’s follow-up in pacing thresholds(0.64±0.16 V vs.0.63±0.22 V)and(0.91±0.28 V vs.0.85±0.20 V),R-wave amplitude(16.68±4.52 mV vs.15.09±4.53 mV)and(14.41±8.65 mV vs.12.65±6.17 mV),pacing impedances(719.24±152.65Ωvs.639.13±177.04Ω)and(534.01±96.92Ωvs.499.18±77.87Ω).But the average ventricular pacing percentage(VP%)at the first month’s follow-up(81.96±32.06%vs.58.37±42.96%)and at the twelfth month’s follow-up(84.65±35.84%vs.53.57±38.47%)showed significant difference between two groups(P<0.05);The LBBP group produced narrower QRSd(121.13±23.91 ms)than the RVOSP group(158.00±9.69 ms)(P=0.011).There were no significant differences between the LBBP group and the RVOSP group at pre-procedure and at the twelfth month’s follow-up in echocardiographic parameters,which included left ventricular end-diastolic dimension(LVEDD)(48.76±7.08 mm vs.47.34±6.91 mm)and(50.58±10.33 mm vs.45.97±7.11 mm),left ventricular ejection fraction(LVEF)(58.33±12.64%vs.61.50±8.40%)and(55.85±16.35%vs.61.50±10.52%),and area of tricuspid regurgitation(TR)(2.79±3.65 cm2 vs.2.85±2.26 cm2)and(3.09±2.34 cm2 vs.2.95±1.92 cm2).No lead and device related complication was observed during follow-ups.Conclusions LBBP is feasible and effective in patients with bradycardia after cardiac surgery.LBBP produces narrow QRSd,which may be a preferred pacing strategy for patients after cardiac surgery.[S Chin J Cardiol 2021;22(1):13-20]
